A5014221430- Birth, Development, and Health
- Forensic and Genetic Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Epigenetics and DNA Methylation
- Agriculture Sustainability and Environmental Impact
- Child Nutrition and Water Access
- Agriculture and Farm Safety
- Obesity, Physical Activity, Diet
- Race, Genetics, and Society
- Yersinia bacterium, plague, ectoparasites research
- Diet and metabolism studies
- Muscle metabolism and nutrition
- Folate and B Vitamins Research
- Pleistocene-Era Hominins and Archaeology
- Eosinophilic Esophagitis
- Sex and Gender in Healthcare
- Genetic Mapping and Diversity in Plants and Animals
- Regulation of Appetite and Obesity
- Genetic diversity and population structure
- Gut microbiota and health
- Peroxisome Proliferator-Activated Receptors
- Thermoregulation and physiological responses
- Vector-Borne Animal Diseases
Kaw Nation
2021
Western Washington University
2008-2018
University of Kansas
2002-2015
University of North Carolina at Chapel Hill
2005-2007
How and when the Americas were populated remains contentious. Using ancient modern genome-wide data, we found that ancestors of all present-day Native Americans, including Athabascans Amerindians, entered as a single migration wave from Siberia no earlier than 23 thousand years ago (ka) after more an 8000-year isolation period in Beringia. After their arrival to Americas, ancestral Americans diversified into two basal genetic branches around 13 ka, one is now dispersed across North South...
This article examines evidence for elevations in basal metabolic rate (BMR) among indigenous Northern (circumpolar) populations and considers potential mechanisms the adaptive basis such elevations. Data on BMR (n = 109 males; 122 females) nonindigenous 15 22 circumpolar groups of North America Siberia are compiled compared to predicted BMRs based three different references: body surface area (Consolazio et al., 1963), mass (Schofield, 1985), fat-free (Poehlman Toth, 1995). Regardless which...
Abstract Hypertension is an important global health issue and currently increasing at a rapid pace in most industrializing nations. Although number of risk factors have been linked with the development hypertension, including obesity, high dietary sodium, chronic psychosocial stress, these cannot fully explain variation blood pressure hypertension rates that occurs within between populations. The present study uses data collected on adults from three indigenous Siberian populations (Evenki,...
Abstract Over the last 20 years, obesity and associated metabolic diseases have emerged as major global health problems. Among urbanizing populations of developing regions world, childhood undernutrition often coexists with adult overnutrition, a phenomenon known “dual nutritional burden”. A recent work (Frisancho 2003 : Am J Hum Biol 15:522–532) suggests that linear growth stunting in early may contribute to by reducing body's ability oxidize fat. We test central aspects this model drawing...
Background The role of circulating levels total homocysteine tHcy in the development coronary heart disease (CHD) is still under debate. One reason for conflicting results between previous studies on and diseases could be consequence different interactions genes study populations. Many genetic factors play a folate-homocysteine metabolism, like functional polymorphism (Val108Met) Catechol-O-methyltransferase (COMT) gene. Methodology Findings Our aim was to examine COMT Val158Met interaction...
Apoproteins (also known as apolipoproteins) have been studied extensively because of their role in lipid transport, association between specific genotypes and elevated serum levels, increased risk heart disease. There is considerable genetic variation the geographic distributions these markers, with a north-south cline APOE*4 allele observed Europe by Lucotte et al. ([1997] Hum Biol 69:253–262). This study compares frequencies seven APO (APOA1 −75 bp, APOA1 +83 APOB Ins/Del, XbaI, APOC3...
We examined mitochondrial DNA (mtDNA) variation in six Mennonite communities from Kansas (Goessel, Lone Tree, Garden View, Meridian, and City) Nebraska (Henderson) to determine their genetic structure its relationship population history. Mitochondrial haplogroup haplotype information were obtained blood samples 118 individuals. Molecular was analyzed using diversity measures, neutrality test statistics, spatial analysis of molecular variance (SAMOVA), multidimensional scaling plots. The...
We examined mitochondrial DNA (mtDNA) variation in six Mennonite communities from Kansas (Goessel, Lone Tree, Garden View, Meridian, and City) Nebraska (Henderson) to determine their genetic structure its relationship population history. Mitochondrial haplogroup haplotype information were obtained blood samples 118 individuals. Molecular was analyzed using diversity measures, neutrality test statistics, spatial analysis of molecular variance (SAMOVA), multidimensional scaling plots. The...
Low levels of high-density lipoprotein (HDL) are widely documented as a risk factor for cardiovascular disease (CVD). Furthermore, there is marked sexual dimorphism in both HDL and the prevalence CVD. However, extent to which genetic factors contribute such has been largely unexplored. We examined evidence genotype-by-sex effects on longitudinal sample 1,562 participants from 330 families Framingham Heart Study at three times points corresponding approximately 1971–1974, 1980–1983,...
Wheat consumption is increasing worldwide and also the frequency of celiac disease (CeD), a pathological response to wheat protein (gluten) in genetically susceptible individuals. Non-celiac gluten sensitivity (NCGS) another, less studied wheat-induced pathology. The treatment for both gluten-free diet (GFD). More individuals choose than predicted by epidemiological 1-2% prevalence. A preliminary survey questionnaire asked members attendees local information group (GIG) meetings functions...
Pooled DNA samples have been used in association studies of Mendelian disease genes. This method involves combining equal quantities from patients and control subjects into separate pools comparing the for distributions genetic markers. In this study identical 300 individuals representing 6 populations were pooled amplified 296 loci using touchdown polymerase chain reaction (PCR) method. The purpose is to test efficacy markers reconstruction structure human populations. sampled included...