A5006627839- Primate Behavior and Ecology
- Genomics and Phylogenetic Studies
- Forensic and Genetic Research
- Genetic diversity and population structure
- Amphibian and Reptile Biology
- Genetic Associations and Epidemiology
- Chromosomal and Genetic Variations
- Evolution and Paleontology Studies
- Animal Behavior and Reproduction
- Genomic variations and chromosomal abnormalities
- Forensic Anthropology and Bioarchaeology Studies
- Genomics and Rare Diseases
- Pleistocene-Era Hominins and Archaeology
- Wildlife Ecology and Conservation
- Archaeology and ancient environmental studies
- Bat Biology and Ecology Studies
- Genetic Mapping and Diversity in Plants and Animals
- Zoonotic diseases and public health
- Insect and Arachnid Ecology and Behavior
- Paleopathology and ancient diseases
- Paleontology and Evolutionary Biology
- Isotope Analysis in Ecology
- Retinal Development and Disorders
- Species Distribution and Climate Change
- Plant and animal studies
Pennsylvania State University
2016-2025
University of Tübingen
2019-2022
Deutsche Forschungsgemeinschaft
2019-2022
Universidad Peruana Cayetano Heredia
2021
The University of Texas at San Antonio
2020
Museum of Indian Arts and Culture
2010-2020
University of Chicago
2008-2011
Arizona State University
2006-2010
Center for Disease Dynamics, Economics & Policy
2004-2010
Brigham and Women's Hospital
2005-2008
Abstract For societies with writing systems, hereditary leadership is documented as one of the hallmarks early political complexity and governance. In contrast, it unknown whether succession played a role in formation prehistoric complex that lacked writing. Here we use an archaeogenomic approach to identify elite matriline persisted between 800 1130 CE Chaco Canyon, centre expansive society Southwestern United States. We show nine individuals buried crypt at Pueblo Bonito, largest structure...
Gene regulation shapes the evolution of phenotypic diversity. We investigated liver promoters and enhancers in six primate species using ChIP-seq (H3K27ac H3K4me1) to profile cis-regulatory elements (CREs) RNA-seq characterize gene expression same individuals. To quantify regulatory divergence, we compared CRE activity across by testing differential read depths directly measured for orthologous sequences. show that landscape is largely conserved lineage, with 63% tested human CREs showing...
Bantu languages are spoken by about 310 million Africans, yet the genetic history of Bantu-speaking populations remains largely unexplored. We generated genomic data for 1318 individuals from 35 in western central Africa, where originated. found that early speakers first moved southward, through equatorial rainforest, before spreading toward eastern and southern Africa. also adaptation was facilitated admixture with local populations, particularly HLA LCT loci. Finally, we identified a major...
Copy number variants (CNVs) underlie many aspects of human phenotypic diversity and provide the raw material for gene duplication family expansion. However, our understanding their evolutionary significance remains limited. We performed comparative genomic hybridization on a single microarray platform to identify CNVs among genomes 30 humans chimpanzees as well fixed copy differences between species. found that chimpanzee occur in orthologous regions far more often than expected by chance...
Copy number variation is surprisingly common among humans and can be involved in phenotypic diversity variable susceptibility to complex diseases, but little known of the extent copy nonhuman primates. We have used two array-based comparative genomic hybridization platforms identify a total 355 variants (CNVs) genomes 20 wild-born chimpanzees (Pan troglodytes) compared identified chimpanzee CNVs human from previous studies. Many were observed corresponding regions both humans; especially...
Genomic-level analyses of DNA from non-invasive sources would facilitate powerful conservation and evolutionary studies in natural populations endangered otherwise elusive species. However, the typical low quantity poor quality that is extracted samples have generally precluded such work. Here we apply a modified capture protocol that, when used combination with massively-parallel sequencing technology, facilitates efficient highly-accurate resequencing megabases specified nuclear genomic...
Comparative genomic studies in primates have yielded important insights into the evolutionary forces that shape genetic diversity and revealed likely basis for certain species-specific adaptations. To date, however, these focused on only a small number of species. For majority nonhuman primates, including some most critically endangered, genome-level data are not yet available. In this study, we taken first steps toward addressing gap by sequencing RNA from livers multiple individuals each...
Woolly mammoths and living elephants are characterized by major phenotypic differences that have allowed them to live in very different environments. To identify the genetic changes underlie suite of woolly mammoth adaptations extreme cold, we sequenced nuclear genome from three Asian two mammoths, identified functionally annotated unique mammoths. We found genes with mammoth-specific amino acid enriched functions related circadian biology, skin hair development physiology, lipid metabolism,...
Significance Squashes, pumpkins, and gourds belonging to the genus Cucurbita were domesticated on several occasions throughout Americas, beginning around 10,000 years ago. The wild forms of these species are unpalatably bitter humans other extant mammals, but their seeds present in mastodon dung deposits, demonstrating that they may have been dispersed by large-bodied herbivores undeterred bitterness. However, poorly adapted a landscape lacking large dispersal partners. Our study proposes...
Significance Tropical rainforest hunter-gatherer populations worldwide share the pygmy phenotype, or small human body size. The evolutionary history of this phenotype is largely unknown. Here we studied DNA from Batwa, a population east central Africa, to identify regions Batwa genome that underlie phenotype. We then performed genomic analyses study evolution these regions, including comparisons with Baka, west African population. conclude likely arose due positive natural selection and it...
Abstract The genetic history of African populations is increasingly well documented, yet their patterns epigenomic variation remain uncharacterized. Moreover, the relative impacts DNA sequence and temporal changes in lifestyle habitat on human epigenome unknown. Here we generate genome-wide genotype methylation profiles for 362 rainforest hunter-gatherers sedentary farmers. We find that current historical a population have similarly critical methylome, but biological functions affected...
This study describes a new tool for accurate and reliable high-throughput detection of copy number variation in the human genome. We have constructed large-insert clone DNA microarray covering entire genome tiling path resolution that we used to identify populations. Crucial this has been development robust array platform analytic process automated identification variants (CNVs). The consists 26,574 clones 93.7% euchromatic regions. Clones were selected primarily from published “Golden...
Copy number variants (CNVs) are heritable gains and losses of genomic DNA in normal individuals. While copy variation is widely studied humans, our knowledge CNVs other mammalian species more limited. We have designed a custom array-based comparative hybridization (aCGH) platform with 385 000 oligonucleotide probes based on the reference genome sequence rhesus macaque (Macaca mulatta), most non-human primate biomedical research. used this to identify 123 among 10 unrelated individuals, 24%...
While color vision perception is thought to be adaptively correlated with foraging efficiency for diurnal mammals, those that forage exclusively at night may not need nor have the capacity it. Indeed, although basic condition mammals dichromacy, diverse nocturnal only monochromatic vision, resulting from functional loss of short-wavelength sensitive opsin gene. However, many primates maintain intact two genes and thus dichromatic capacity. The evolutionary significance this surprising...