A5011892373- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Genomics and Phylogenetic Studies
- Primate Behavior and Ecology
- Chromosomal and Genetic Variations
- Single-cell and spatial transcriptomics
- Machine Learning in Bioinformatics
- Diet and metabolism studies
- Tryptophan and brain disorders
- Neuropeptides and Animal Physiology
- Genomic variations and chromosomal abnormalities
- Genetic diversity and population structure
- Bipolar Disorder and Treatment
- Genetics and Neurodevelopmental Disorders
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Biochemical Analysis and Sensing Techniques
- Neuroscience and Neuropharmacology Research
- Genetics, Aging, and Longevity in Model Organisms
- Epigenetics and DNA Methylation
- Evolution and Genetic Dynamics
- Neuroinflammation and Neurodegeneration Mechanisms
- Genomics and Chromatin Dynamics
- Fractal and DNA sequence analysis
- Gut microbiota and health
University of Mississippi Medical Center
2016-2025
Jackson Memorial Hospital
2016-2025
Tulane University
2016-2025
University of Mississippi
2015-2021
Harvard University
2008-2019
New England Biolabs (United States)
2008-2019
State Street (United States)
2018
Primate Conservation
2012
New England Center for Children
2012
Lemuel Shattuck Hospital
2011
The gene Microcephalin ( MCPH1 ) regulates brain size and has evolved under strong positive selection in the human evolutionary lineage. We show that one genetic variant of modern humans, which arose ∼37,000 years ago, increased frequency too rapidly to be compatible with neutral drift. This indicates it spread selection, although exact nature is unknown. finding an important continued evolve adaptively anatomically humans suggests ongoing plasticity brain. It also makes attractive candidate...
The gene ASPM ( abnormal spindle-like microcephaly associated ) is a specific regulator of brain size, and its evolution in the lineage leading to Homo sapiens was driven by strong positive selection. Here, we show that one genetic variant humans arose merely about 5800 years ago has since swept high frequency under These findings, especially remarkably young age positively selected variant, suggest human still undergoing rapid adaptive evolution.
A prominent trend in the evolution of humans is progressive enlargement cerebral cortex. The ASPM (Abnormal spindle-like microcephaly associated) gene has potential to play a role this evolu-tionary process, because mutations cause severe reductions cortical size affected humans. Here, we show that significantly accelerated great apes, especially along ape lineages leading Additionally, lineage from last human/chimpanzee ancestor shows an excess non-synonymous over synonymous substitutions,...
Rhesus macaques ( Macaca mulatta ) are the most widely used nonhuman primate in biomedical research, have largest natural geographic distribution of any primate, and been focus much evolutionary behavioral investigation. Consequently, rhesus one thoroughly studied species. However, little is known about genome-wide genetic variation this A detailed understanding extant genomic among has implications for use species as a model studies human health disease, well population genomics....
At the center of debate on emergence modern humans and their spread throughout globe is question whether archaic Homo lineages contributed to human gene pool, more importantly, such contributions impacted evolutionary adaptation our species. A major obstacle answering this that low levels admixture with are not expected leave extensive traces in pool because genetic drift. Loci have undergone strong positive selection, however, offer a unique opportunity identify low-level lineages, provided...
Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled that directly responds to endogenous monoamines as well amphetamine-related psychostimulants, including methamphetamine. In the present study, we demonstrate TAAR1 mRNA and protein expression in rhesus monkey brain regions associated with monoaminergic systems, variable cellular distribution of brain, coexpression dopamine transporter (DAT) subset neurons both mouse substantia nigra. On this basis, evaluated activation by...
Copy number variants (CNVs) are heritable gains and losses of genomic DNA in normal individuals. While copy variation is widely studied humans, our knowledge CNVs other mammalian species more limited. We have designed a custom array-based comparative hybridization (aCGH) platform with 385 000 oligonucleotide probes based on the reference genome sequence rhesus macaque (Macaca mulatta), most non-human primate biomedical research. used this to identify 123 among 10 unrelated individuals, 24%...
Abstract 3‐Iodothyronamine (T1AM) is a metabolite of thyroid hormone. It an agonist at trace amine‐associated receptor 1 (TAAR1), recently identified involved in monoaminergic regulation and potential novel therapeutic target. Here, T1AM was studied using rhesus monkey TAAR1 and/or human dopamine transporter (DAT) co‐transfected cells, wild‐type (WT) knock‐out (KO) mice. The IC 50 competition for binding the DAT‐specific radio‐ligand [ 3 H]CFT highly similar DAT WT striatal synaptosomes KO...
Complete exome resequencing has the power to greatly expand our understanding of non-human primate genomes. This includes both a better appreciation variation that exists in model species, but also an improved annotation their By developing between individuals, models human disease can be developed. effort is hindered largely by lack comprehensive information on specific genetic and costs generating these data. If tools have been developed humans for complete applied closely related then...
Copy number variants (CNVs), defined as losses and gains of segments genomic DNA, are a major source variation. In this study, we identified over 2,000 human CNVs that overlap with orthologous chimpanzee or macaque CNVs. Of these, 170 both CNVs, these were collapsed into 34 hotspot regions CNV formation. Many formation functionally relevant, bias toward genes involved in immune function, some which previously shown to evolve under balancing selection humans. The primate hotspots have...
Abstract Background Marmosets are playing an increasingly large and important role in biomedical research. They share genetic, anatomical, physiological similarities with humans other primate model species, but their smaller sizes, reproductive efficiency, amenability to genetic manipulation offer added practicality. While unique biology can be exploited provide insights into disease function, it is also that researchers aware of the differences exist between marmosets species. The New World...
To study the genomic divergence between human and chimpanzee, large-scale sequence alignments were performed. The sequences of chimpanzee first masked with RepeatMasker repeats excluded before alignments. then reinserted into nonrepetitive segments entire aligned again. A total 2.3 million base pairs (Mb) sequences, including repeats, average nucleotide was estimated to be 1.22%. Jukes–Cantor (JC) distances (nucleotide divergences) in (1.44 Mb) repetitive (0.86 are 1.14% 1.34%, respectively,...