A5101959780- Colorectal Cancer Screening and Detection
- Nutrition and Health in Aging
- Cancer, Lipids, and Metabolism
- Diet and metabolism studies
- Gastric Cancer Management and Outcomes
- Metabolomics and Mass Spectrometry Studies
- Cancer survivorship and care
- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Gut microbiota and health
- Pancreatic and Hepatic Oncology Research
- Inflammatory Biomarkers in Disease Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Diverticular Disease and Complications
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Circular RNAs in diseases
- Nutritional Studies and Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Vitamin D Research Studies
- Cancer, Hypoxia, and Metabolism
- Cancer Risks and Factors
National Center for Tumor Diseases
2016-2025
German Cancer Research Center
2016-2025
Heidelberg University
2016-2025
University Hospital Heidelberg
2023-2024
Huntsman Cancer Institute
2016
German Marine Research Consortium
2016
University Hospital Schleswig-Holstein
2016
University of Lübeck
2016
DKFZ-ZMBH Alliance
2016
Krebsregister Saarland
2016
Objective Resection can potentially cure resectable pancreatic cancer (PaC) and significantly prolong survival in some patients. This large-scale international study aimed to investigate variations resection for PaC Europe USA determinants its utilisation. Design Data from six European population-based registries the US Surveillance, Epidemiology, End Results Program database during 2003–2016 were analysed. Age-standardised rates overall stage I–II PaCs computed. Associations between...
The prognosis of pancreatic cancer (PaC) strongly varies across different stages and age groups, which has unfortunately not been well recorded in the literature. This international population-based study aimed to provide tumor-node-metastasis (TNM) stage- age-specific survival estimates trends resected overall (resected unresected) PaC early twenty-first century.Using data from US Surveillance, Epidemiology, End Results-18 Program national registries Netherlands, Belgium, Norway, Slovenia,...
A variety of fecal immunochemical tests (FITs) for hemoglobin (Hb) are used in colorectal cancer screening. It is unclear to what extent differences reported sensitivities and specificities reflect true heterogeneity test performance or study populations varying pre-analytical conditions. We directly compared the sensitivity specificity values with which 9 quantitative (laboratory-based point-of-care) FITs detected advanced neoplasms (AN) a single screening study.Pre-colonoscopy stool...
Colorectal cancer is known to arise from multiple tumorigenic pathways; however, the underlying mechanisms remain not completely understood. Metabolomics becoming an increasingly popular tool in assessing biological processes. Previous metabolomics research focusing on colorectal limited by sample size and did replicate findings independent study populations verify robustness of reported findings. Here, we performed a ultrahigh performance liquid chromatography‐quadrupole time‐of‐flight mass...
Pancreatic cancer (PaC) remains extremely lethal worldwide even after resection. PaC resection rates are low, making prognostic studies in resected difficult. This large international population-based study aimed at exploring factors associated with survival patients TNM stage I-II receiving chemotherapy and developing internationally validating a survival-predicting model.
Quality of life (QoL) is an important clinical outcome in cancer patients. We investigated associations between dietary patterns and QoL changes colorectal (CRC) The study included 192 CRC patients with available EORTC QLQ-C30 data before 12 months post-surgery food frequency questionnaire at post-surgery. Principal component analysis was used to identify patterns. Multivariate regression models assessed over time. identified four major patterns: "Western" pattern characterized by high...
Physical activity plays an important role in colorectal cancer and accelerometry is more frequently used to measure physical activity. The aim of this study was evaluate feasibility measurement by patients under free-living conditions at 6, 12 24 months after surgery, the appropriate wear time compare results pedometry.Colorectal (stage 0/I-IV) from ColoCare were asked optionally accelerometer a pedometer for ten consecutive days post-surgery. Participants completed feedback questionnaire...
Abstract Background Chronic inflammation is a risk factor for colorectal cancer (CRC). Circulating C-reactive protein (CRP) also moderately associated with CRC risk. However, observational studies are susceptible to unmeasured confounding or reverse causality. Using genetic variants as instrumental variables, we investigated the causal relationship between genetically elevated CRP concentration and risk, using Mendelian randomization approach. Methods Individual-level data from 30 480 cases...
The advantage of adjuvant chemotherapy (ACT) for treating Stage III colon cancer patients is well established and widely accepted. However, many with do not receive ACT. Moreover, there are controversies around the effectiveness ACT II patients. We investigated administration its association overall survival in resected (overall stratified by low‐/high‐risk) three European countries including Netherlands (2009–2014), Belgium (2009–2013) Sweden (2009–2014). Hazard ratios (HR) death were...
Colorectal cancer is the second most common cause of cancer‐related death globally, with marked differences in prognosis by disease stage at diagnosis. We studied circulating metabolites relation to improve understanding metabolic pathways related colorectal progression. investigated plasma concentrations 130 among 744 Stages I–IV patients from ongoing cohort studies. Plasma samples, collected diagnosis, were analyzed liquid chromatography‐mass spectrometry using Biocrates AbsoluteIDQ™ p180...
Abstract Circulating microRNAs (miRNAs) could improve colorectal cancer (CRC) risk prediction. Here, we derive a blood-based miRNA panel and evaluate its ability to predict CRC occurrence in population-based cohort of adults aged 50–75 years. Forty-one miRNAs are preselected from independent studies measured by quantitative-real-time-polymerase-chain-reaction serum collected at baseline 198 participants who develop during 14 years follow-up 178 randomly selected controls. A 7-miRNA score is...
•Patients were treated with surgery for CRC.•Post-operative CRP (poCRP) was measured from blood collected ≥1 month after surgery.•Associations of poCRP long-term survival assessed using Cox regression.•Elevated independently associated poorer survival.•poCRP may be valuable CRC surveillance. BackgroundPost-surgery blood-based biomarkers useful guiding treatment and surveillance decisions among colorectal cancer (CRC) patients. However, most candidate provide little if any predictive value...
Adiposity has been linked to both risk and prognosis of colorectal cancer; however, the impact different fat areas [visceral (VFA) vs. subcutaneous area (SFA)] is unclear. We investigated associations between adiposity biomarkers inflammation angiogenesis among patients with cancer.Preoperative serum samples computed tomography scans were obtained from 188 diagnosed primary invasive stage I-IV cancer enrolled in ColoCare Study. was assessed by area-based quantification VFA, SFA, VFA:SFA...
Blood-based protein biomarkers may be an attractive option for early detection of colorectal cancer (CRC). Here, we used a two-stage design to measure 275 markers by proximity extension assay (PEA), first in plasma samples discovery set consisting 98 newly diagnosed CRC cases and 100 age- gender-matched controls free neoplasm at screening colonoscopy. An algorithm predicting the presence early- or late-stage was derived least absolute shrinkage selection operator regression with .632+...