A5025175956- Epigenetics and DNA Methylation
- Nutrition, Genetics, and Disease
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- Bioinformatics and Genomic Networks
- Cancer, Lipids, and Metabolism
- HER2/EGFR in Cancer Research
- Metabolism, Diabetes, and Cancer
- Advanced Breast Cancer Therapies
- Dietary Effects on Health
- Diet and metabolism studies
- Lung Cancer Treatments and Mutations
- BRCA gene mutations in cancer
- Cancer-related molecular mechanisms research
- Cancer Risks and Factors
- Cancer, Hypoxia, and Metabolism
- Estrogen and related hormone effects
- Breast Lesions and Carcinomas
- Immunotherapy and Immune Responses
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Cancer Treatment and Pharmacology
- Radiomics and Machine Learning in Medical Imaging
Fondazione IRCCS Istituto Nazionale dei Tumori
2019-2025
University of Milan
2013-2025
Italian Oncology Group of Clinical Research
2024
Tumori Foundation
2023
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2023
European Institute of Oncology
2012-2022
IFOM
2021
Clatterbridge Cancer Centre NHS Foundation Trust
2018
Imperial College Healthcare NHS Trust
2018
Imperial College London
2018
Purpose The aim of the current study was to conduct a pooled analysis studies that have investigated prognostic value tumor-infiltrating lymphocytes (TILs) in early-stage triple negative breast cancer (TNBC). Methods Participating had evaluated percentage infiltration stromally located TILs (sTILs) were quantified same manner patient diagnostic samples TNBC treated with anthracycline-based chemotherapy or without taxanes. Cox proportional hazards regression models stratified by trial used...
For primary triple-negative breast cancer (TNBC) treated with neoadjuvant chemotherapy (NAC), higher pretreatment tumor-infiltrating lymphocytes (TILs) correlates increased pathologic complete response (pCR) rates, and improved survival. We evaluated the added prognostic value of residual disease (RD) TILs to burden (RCB) in predicting survival post-NAC.
AURORA aims to study the processes of relapse in metastatic breast cancer (MBC) by performing multi-omics profiling on paired primary tumors and early-course metastases. Among 381 patients (primary tumor metastasis pairs: 252 targeted gene sequencing, 152 RNA 67 single nucleotide polymorphism arrays), we found a driver role for GATA1 MEN1 somatic mutations. Metastases were enriched ESR1, PTEN, CDH1, PIK3CA, RB1 mutations; MDM4 MYC amplifications; ARID1A deletions. An increase clonality was...
Abstract In tumor-bearing mice, cyclic fasting or fasting-mimicking diets (FMD) enhance the activity of antineoplastic treatments by modulating systemic metabolism and boosting antitumor immunity. Here we conducted a clinical trial to investigate safety biological effects cyclic, five-day FMD in combination with standard therapies. 101 patients, was safe, feasible, resulted consistent decrease blood glucose growth factor concentration, thus recapitulating metabolic changes that mediate...
The importance of integrating biomarkers into the TNM staging has been emphasized in 8th Edition American Joint Committee on Cancer (AJCC) Staging system. In a pooled analysis 2148 TNBC-patients adjuvant setting, TILs are found to strongly up and downstage traditional pathological-staging Pathological Clinical Prognostic Stage Groups from AJJC edition System. This suggest that clinical research studies TNBC should take account addition stage, as for example patients with stage II high have...
Abstract Patients with estrogen receptor–positive breast cancer receive adjuvant endocrine therapies (ET) that delay relapse by targeting clinically undetectable micrometastatic deposits. Yet, up to 50% of patients even decades after surgery through unknown mechanisms likely involving dormancy. To investigate genetic and transcriptional changes underlying tumor awakening, we analyzed late longitudinally profiled a rare cohort treated long-term neoadjuvant ETs until progression. Next,...
•ctDNA was detected in 77% of early-stage TNBC patients undergoing neoadjuvant chemotherapy.•Patients with still detectable ctDNA after NAC were more than twice as likely to relapse those undetectable levels.•Detection during follow-up antedated clinical overt metastases up 13 months.•ctDNA all but one non-recurrent patient a temporary peak only 1 8 samples tested.•CTCs progressing cases lacked epithelial surface markers and showed therapeutically exploitable molecular features. BackgroundAs...
Whether Human Epidermal growth factor Receptor 2 (HER2)-low status has prognostic significance in HR + /HER2- advanced Breast Cancer (aBC) patients treated with first-line Endocrine Therapy plus CDK 4/6 inhibitors remains unclear. In 428 evaluated, HER2-low was independently associated significantly worse PFS and OS when compared HER2-0 status. Based on our findings, could become a new biomarker this clinical setting.
To ascertain the prognostic relevance of micropapillary carcinoma, a specific type breast tumour.We interrogated clinical records series 49 pure carcinoma patients and 13 487 invasive ductal patients, diagnosed treated consecutively in our institution over 9-year time-frame. Compared with more frequently had moderately differentiated tumours (P = 0.02) extensive peritumoral vascular invasion < 0.0001), associated significantly higher rate axillary lymph node involvement 0.0001). Survival...
Thyroid carcinoma (TC) comprises several histotypes with different aggressiveness, from well (papillary carcinoma, PTC) to less differentiated forms (poorly and anaplastic thyroid PDTC ATC, respectively). Previous reports have suggested a functional role for cancer-associated fibroblasts (CAFs) or senescent TC cells in the progression of PTC. In this study, we investigated presence CAFs proprietary human TCs including PTC, PDTC, ATC. Screening driving lesions BRAFV600E N/H/KRAS mutations,...
Nano-and microsized extracellular vesicles (EVs) are naturally occurring cargo-bearing packages of regulatory macromolecules, and recent studies increasingly showing that EVs responsible for physiological intercellular communication.Nanoparticles encapsulating anti-tumor theranostics represent an attractive "exosome-interfering" strategy cancer therapy.Methods: Herein, by labeling plasma-derived with indocyanine green (ICG) following their biodistribution in vivo ex imaging, we demonstrate...
The clinical relevance of circulating tumor cell clusters (CTC-clusters) in breast cancer (BC) has been mostly studied using the CellSearch®, a marker-dependent method detecting only epithelial-enriched clusters. However, due to epithelial-to-mesenchymal transition, resorting marker-independent approaches can improve CTC-cluster detection. Blood samples collected from healthy donors and spiked-in with mammospheres, or BC patients, were processed for detection 3 technologies: CellSieve™...