A5045165615- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Virus-based gene therapy research
- Bacteriophages and microbial interactions
- Tissue Engineering and Regenerative Medicine
- Alzheimer's disease research and treatments
- Sirtuins and Resveratrol in Medicine
- Advanced Neuroimaging Techniques and Applications
- Neonatal and fetal brain pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Cholinesterase and Neurodegenerative Diseases
- Circular RNAs in diseases
- Medical Imaging and Pathology Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Traumatic Brain Injury Research
- Nanoplatforms for cancer theranostics
- Genetic Syndromes and Imprinting
- Histone Deacetylase Inhibitors Research
- Skin and Cellular Biology Research
- S100 Proteins and Annexins
University of Milan
2018-2024
Centro San Giovanni di Dio Fatebenefratelli
2023-2024
Standard of care for cancer is commonly a combination surgery with radiotherapy or chemoradiotherapy. However, in some advanced patients this approach might still remaininefficient and may cause many side effects, including severe complications even death. Oncolytic viruses exhibit different anti-cancer mechanisms compared conventional therapies, allowing the possibility improved effect therapy. Chemotherapeutics combined oncolytic stronger cytotoxic responses oncolysis. Here, we have...
Extracellular vesicles (EVs) are naturally occurring cargo delivery that have recently received considerable attention for their roles in intercellular communication many physiological and pathological processes, including tumourigenesis. EVs generated by different tissues demonstrated specific homing: particular, cancer-derived showed a selective tropism the tumor tissue from which originated. For this property, been proposed as drug tools anti-cancer therapies, although limited knowledge...
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been proposed as chemopreventive agents for many tumours; however, the mechanism responsible their anti-neoplastic activity remains elusive and side effects due to cyclooxygenase (COX) inhibition prevent this clinical application. Molecular biology, in silico, cellular vivo tools, including innovative imaging classical biochemical assays, were applied identify characterise COX-independent anti-cancer of NSAIDs. Here, we show that...
Nano-and microsized extracellular vesicles (EVs) are naturally occurring cargo-bearing packages of regulatory macromolecules, and recent studies increasingly showing that EVs responsible for physiological intercellular communication.Nanoparticles encapsulating anti-tumor theranostics represent an attractive "exosome-interfering" strategy cancer therapy.Methods: Herein, by labeling plasma-derived with indocyanine green (ICG) following their biodistribution in vivo ex imaging, we demonstrate...
Alzheimer's disease (AD) and frontotemporal dementia (FTD) are the two major neurodegenerative diseases causing dementia. Due to similar clinical phenotypes, differential diagnosis is challenging without specific biomarkers. Beta-site Amyloid Precursor Protein cleaving enzyme 1 (BACE1) a β-secretase pivotal in AD pathogenesis. In mild cognitive impairment subjects, BACE1 activity increased brain/cerebrospinal fluid, plasma levels appear reflect those brain. this study, we aim evaluate serum...
From the past decade, extracellular vesicles (EVs) have attracted considerable attention as tools for selective delivery of anti-neoplastic drugs to cancer tissues. Compared other nanoparticles, EVs display interesting unique features including immune compatibility, low toxicity and ability encapsulate a large variety small- macro-molecules. However, in virtually all studies, investigations on been focused fully transformed cancers: possibility apply EV technology also early-stage tumors has...
Extracellular vesicles (EVs) derived from the plasma of oncological patients exhibit significant tumor-targeting properties, unlike those healthy individuals. We have previously shown feasibility formulating near-infrared (NIR) fluorescent dye indocyanine green (ICG) with patient-derived extracellular (PDEVs) for selective delivery to neoplastic tissue. This staining protocol holds promise clinical application in intraoperative tumor margin imaging, enabling precise tissue resection. To this...
Computed tomography (CT) is a diagnostic medical imaging modality commonly used to detect disease and injury. Contrast agents containing iodine, such as iohexol, are frequently in CT examinations more clearly differentiate anatomic structures characterize abnormalities, including tumors. However, these contrast do not have specific tropism for cancer cells, so the ability tumors severely limited by degree of vascularization tumor itself. Identifying delivery systems allowing enrichment at...