A5045624001- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Global Cancer Incidence and Screening
- Economic and Financial Impacts of Cancer
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Multiple and Secondary Primary Cancers
- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Cancer survivorship and care
- Cancer Genomics and Diagnostics
- Advances in Oncology and Radiotherapy
- Lung Cancer Research Studies
- Palliative Care and End-of-Life Issues
- Clinical practice guidelines implementation
- Health Systems, Economic Evaluations, Quality of Life
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Ethics in Clinical Research
- Hemoglobinopathies and Related Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Electronic Health Records Systems
- Pleural and Pulmonary Diseases
Baptist Cancer Center
2016-2025
Eugene O'Neill Theater Center
2024
Vanderbilt University
2024
Baptist Memorial Health Care
2012-2024
Baptist Medical Center Jacksonville
2024
Regional Cancer Center
2018-2023
AstraZeneca (Switzerland)
2022
American Cancer Society
2022
Association of Community Cancer Centers
2022
Baptist Memorial Hospital
2020
A single amino acid substitution in hemoglobin comprises the molecular basis for sickle cell anemia, but evolution of corresponding clinical disease is extraordinarily complicated and likely involves multiple pathogenic factors. Sickle fundamentally an inflammatory state, with activation endothelium, probably through proximate effects reperfusion injury physiology chronic molestation by adherent red cells white cells. The also enhanced angiogenic propensity, coagulation, disordered...
Most patients with non–small cell lung cancer (NSCLC) are diagnosed advanced cancer. These guidelines only include information about stage IV NSCLC. Patients widespread metastatic disease (stage IV) candidates for systemic therapy, clinical trials, and/or palliative treatment. The goal is to identify before initiating aggressive treatment, thus sparing these from unnecessary futile If discovered during surgery, then extensive surgery often aborted. Decisions treatment should be based on...
Overview Upper gastrointestinal tract cancers originating in the esophagus, esophagogastric junction (EGJ), and stomach constitute a major health problem around world. An estimated 37,640 new cases of 25,070 deaths from upper occurred United States 2010.1 A dramatic shift location tumors has States.2,3 Changes hisNCCN
PURPOSE Patients with cancer living in socioeconomically disadvantaged areas have worse outcomes. The association between socioeconomic deprivation and outcomes among patients participating clinical trials has not been systematically examined. METHODS We examined survival for enrolled phase III large II major cancers conducted by the SWOG Cancer Research Network from 1985 to 2012. Socioeconomic was measured using trial participants' residential zip codes linked Area Deprivation Index (ADI)....
Gastric cancer is rampant in several countries around the world. Its incidence West has been on decline for more than 40 years; however, location of gastric shifted proximally past 15 years. The reason this shift not clear. Diffuse histology also common now intestinal type histology. Advances have made staging procedures such as laparoscopy and endoscopic ultrasonography possible functional imaging techniques. current TNM classification requires an examination at least lymph nodes;...
Pathologic nodal stage is the key prognostic factor in resectable non-small-cell lung cancer (NSCLC). Mediastinal lymph node (MLN) metastasis connotes a poor prognosis. Yet, some NSCLC resections exclude MLN examination.We analyzed U.S. Surveillance, Epidemiology, and End Results program data from 1998 to 2002 quantify long-term survival impact of failure examine resected NSCLC. We used Kaplan-Meier methods compare unadjusted difference between patients with, without, examination, Cox...
Pathologic nodal stage is the most significant prognostic factor in resectable non-small cell lung cancer (NSCLC). The International Association for Study of Lung Cancer NSCLC staging project revealed intercontinental differences N category-stratified survival. These may indicate not only biology but also thoroughness examination.To determine whether survival was affected by sequentially more stringent definitions pN quality a cohort patients with after resection curative intent.This...
Many clinical trials supporting new drug applications underrepresent minority patients. Trials conducted by the National Cancer Institute's Clinical Trial's Network (NCTN) have greater outreach to community sites, potentially allowing better representation. We compared representation of Black patients in pharmaceutical company-sponsored cancer with NCTN and US population.
Avoidable differences in the care and outcomes of patients with cancer (i.e., disparities) emerge or worsen discoveries new, more effective approaches to diagnosis treatment. The rapidly expanding use immunotherapy for many different cancers across spectrum from late early stages has, predictably, been followed by emerging evidence disparities access these highly but expensive treatments. danger that new treatments will further widen preexisting outcome requires urgent corrective...
PURPOSE Lung cancer screening saves lives, but implementation is challenging. We evaluated two approaches to early lung detection—low-dose computed tomography (LDCT) and program-based management of incidentally detected nodules. METHODS A prospective observational study enrolled patients in the detection programs. For context, we compared them with managed a Multidisciplinary Care Program. clinical stage distribution, surgical resection rates, 3- 5-year survival eligibility for LDCT...
Standard treatment for resectable non-small cell lung cancer (NSCLC) includes anatomic resection with adequate lymph node dissection and adjuvant chemotherapy appropriate patients. Historically, many patients early-stage NSCLC have not received such treatment, which may affect the interpretation of results therapy trials.
Collecting patient-reported outcomes (PROs) can improve symptom control and quality of life, enhance doctor-patient communication, reduce acute care needs for patients with cancer. Digital solutions facilitate PRO collection, but without robust electronic health record (EHR) integration, effective deployment be hampered by low patient clinician engagement high development costs. The important components digital platforms have been defined, procedures implementing integrated are not readily...
Low-dose computer tomographic (LDCT) lung cancer screening reduces cancer-specific and all-cause mortality among high-risk individuals, but implementation has been challenging. Despite health insurance coverage for in the United States since 2015, fewer than 10% of eligible persons have participated; striking geographic, racial, socioeconomic disparities were already evident, especially populations at greatest risk and, therefore, most likely to benefit from screening; adherence subsequent...
Pathologic nodal stage affects prognosis in patients with surgically resected non-small-cell lung cancer (NSCLC). Unlike examination of mediastinal lymph nodes (LNs), which depends on surgical practice, accurate intrapulmonary (N1) primarily pathology practice. We investigated the completeness N1 LN NSCLC resection specimens and its potential impact stage.We performed a case-control study special pathologic (SPE) protocol using thin gross dissection retrieval microscopic all LN-like material...