Robert Optican

ORCID: 0009-0004-9585-3213
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About
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Research Areas
  • Lung Cancer Diagnosis and Treatment
  • Global Cancer Incidence and Screening
  • Lung Cancer Treatments and Mutations
  • Radiology practices and education
  • Radiation Dose and Imaging
  • Colorectal Cancer Screening and Detection
  • Cardiovascular Disease and Adiposity
  • Cardiac Imaging and Diagnostics
  • Head and Neck Cancer Studies
  • Adipose Tissue and Metabolism
  • Radiomics and Machine Learning in Medical Imaging
  • Esophageal Cancer Research and Treatment
  • Emergency and Acute Care Studies
  • Medical Imaging and Pathology Studies
  • Pharmaceutical industry and healthcare
  • Trauma and Emergency Care Studies
  • Cardiovascular Effects of Exercise
  • Infectious Diseases and Tuberculosis
  • Diagnosis and treatment of tuberculosis
  • Medical Malpractice and Liability Issues
  • Public Health Policies and Education
  • Health Systems, Economic Evaluations, Quality of Life
  • Sports injuries and prevention
  • Traumatic Ocular and Foreign Body Injuries
  • Economic and Financial Impacts of Cancer

Duke University Health System
2024

Duke University
2023

Duke Medical Center
1991-2022

Association of Community Cancer Centers
2022

AstraZeneca (Switzerland)
2022

American Cancer Society
2022

Duke University Hospital
1991-2022

VA MidSouth Healthcare Network
2021

Baptist Memorial Hospital
2009-2015

Cleveland Clinic
1998

Uncoupling protein-1 (UCP-1) is the inner mitochondrial membrane protein that a specific marker for and mediator of nonshivering thermogenesis in brown adipocytes.This study was performed to better understand putative thermogenic function human epicardial fat.We measured expression UCP-1 adipocyte differentiation transcription factors PR-domain-missing 16 (PRDM16) peroxisome-proliferator-activated receptor gamma co-activator-1 alpha (PGC-1 alpha) epicardial, substernal, sc thoracic,...

10.1210/jc.2009-0571 article EN The Journal of Clinical Endocrinology & Metabolism 2009-07-01

PURPOSE Lung cancer screening saves lives, but implementation is challenging. We evaluated two approaches to early lung detection—low-dose computed tomography (LDCT) and program-based management of incidentally detected nodules. METHODS A prospective observational study enrolled patients in the detection programs. For context, we compared them with managed a Multidisciplinary Care Program. clinical stage distribution, surgical resection rates, 3- 5-year survival eligibility for LDCT...

10.1200/jco.21.02496 article EN cc-by Journal of Clinical Oncology 2022-03-08

NIH Conferences18 May 2010National Institutes of Health State-of-the-Science Conference Statement: Enhancing Use and Quality Colorectal Cancer ScreeningFREEDonald Steinwachs, PhD, Jennifer Dacey Allen, DSc, MPH, RN, William Eric Barlow, R. Paul Duncan, Leonard E. Egede, MD, MS, Lawrence S. Friedman, Nancy L. Keating, Paula Kim, Judith Lave, Thomas A. LaVeist, Roberta B. Ness, Robert J. Optican, Beth Virnig, MPH*Donald PhDFrom The Johns Hopkins University Bloomberg School Public Health,...

10.7326/0003-4819-152-10-201005180-00237 article EN Annals of Internal Medicine 2010-05-18

To evaluate right ventricular abnormalities with magnetic resonance (MR) imaging in patients arrhythmia but without arrhythmogenic dysplasia.In 53 being evaluated for and 15 control subjects, MR was performed to fixed thinning, fatty replacement, or reduced systolic wall thickening motion. A diagnosis of idiopathic outflow tract tachycardia indeterminate assigned each patient, the severity categorized.Right were revealed 32 (60%) patients: thinning 27 (84%), replacement eight (25%), motion...

10.1148/radiology.207.3.9609899 article EN Radiology 1998-06-01

IntroductionWe compared NSCLC treatment and survival within outside a multidisciplinary model of care from large community health system.MethodsWe implemented rigorously benchmarked "enhanced" Multidisciplinary Thoracic Oncology Conference (eMTOC) used Tumor Registry data (2011–2017) to evaluate guideline-concordant care. Because eMTOC was located in metropolitan Memphis, we separated non-MTOC patient by regional location. We categorized National Comprehensive Cancer Network as "preferred,"...

10.1016/j.jtocrr.2021.100203 article EN cc-by-nc-nd JTO Clinical and Research Reports 2021-07-03

Aims: Obesity is associated with a chronic systemic low-grade inflammatory state.Markers of inflammation such as TNF-␣ are linked increased risk for insulin resistance and type 2 diabetes.The objective the present study was to dissect molecular mechanisms that may regulate TNF-␣-induced in human adipose tissue.Methods: We analyzed impact on glucose uptake action visceral sc adipocytes.The contribution different intracellular signaling pathways metabolic effects reversal some these nuclear...

10.1210/mend.23.9.9997 article EN Molecular Endocrinology 2009-09-01

10.1067/j.cpradiol.2023.12.004 article EN Current Problems in Diagnostic Radiology 2023-12-22

10.1067/j.cpradiol.2024.03.004 article EN Current Problems in Diagnostic Radiology 2024-03-07

10.1067/j.cpradiol.2024.05.020 article EN Current Problems in Diagnostic Radiology 2024-05-07

Goitrous cretinism manifesting as newborn stridor: CT evaluation.R J Optican, K S White and E L EffmannAudio Available | Share

10.2214/ajr.157.3.1872244 article EN American Journal of Roentgenology 1991-09-01

This article does not include an abstract.Please see the accompanying Point by Jeffrey P. Kanne.

10.2214/ajr.22.28644 article EN American Journal of Roentgenology 2022-11-02
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