To assess the frequency, intensity, and clinical impact of [18F]FDG-avidity axillary lymph nodes after vaccination with COVID-19 vaccines BNT162b2 (Pfizer-BioNTech) mRNA-1273 (Moderna) in patients referred for oncological FDG PET/CT.One hundred forty PET/CT during February March 2021 first or second Pfizer-BioNTech Moderna were retrospectively included. FDG-avidity ipsilateral was measured compared. Assuming no knowledge prior vaccination, metastatic risk analyzed by two readers...

33 Background: PSMA-PET/CT is increasingly being used to monitor chemotherapy in prostate cancer and shows promise for predicting outcomes improving response evaluation. This retrospective study aimed determine the prognostic value of quantitative tumor burden parameters derived from overall survival (OS) during taxane-based chemotherapy. Methods: Databases 6 institutions were screened patients who underwent[ 68 Ga]Ga-PSMA11-PET serum PSA measurements at baseline within three months after...

The purpose of this study was to assess whether the performances an automated software for lung nodule detection with computed tomography (CT) are affected by radiation dose and use iterative reconstruction algorithm.A chest phantom (Multipurpose Chest Phantom N1; Kyoto Kagaku Co. Ltd, Kyoto, Japan) 15 pulmonary nodules scanned a total five CT protocol settings up 20-fold reduction. All examinations were reconstructed algorithms ADMIRE 3 5 then analyzed presence fully computer aided system...

To assess the accuracy of fully automated deep learning (DL) based coronary artery calcium scoring (CACS) from non-contrast computed tomography (CT) as acquired for attenuation correction (AC) cardiac single-photon-emission myocardial perfusion imaging (SPECT-MPI). Patients were enrolled in this study part a larger prospective (NCT03637231). In study, 56 who underwent SPECT-MPI due to suspected disease (CAD) prospectively enrolled. All patients CT AC twice. CACS was manually assessed...

Background: Investigation of the clinical feasibility dynamic whole-body (WB) [18F]FDG PET, including standardized uptake value (SUV), rate irreversible (Ki), and apparent distribution volume (Vd) in physiologic tissues, comparison between inflammatory/infectious cancer lesions. Methods: Twenty-four patients were prospectively included to undergo WB PET/CT for clinically indicated re-/staging oncological diseases. Parametric maps Ki Vd generated using Patlak analysis alongside SUV images....

Objectives: To evaluate the impact of fully automatic motion correction by data-driven respiratory gating (DDG) on positron emission tomography (PET) image quality, lesion detection and patient management. Materials Methods: A total 149 patients undergoing PET/CT for cancer (re-)staging were retrospectively included. Patients underwent a digital detector scanner every PET data set where DDG was enabled (PETDDG) as well not (PETnonDDG) reconstructed. All sets evaluated two readers which rated...

PSMA PET/MRI showed the potential to increase sensitivity for extraprostatic disease (EPD) assessment over mpMRI; however, interreader variability EPD is still high. Therefore, we aimed assess whether quantitative and mpMRI imaging parameters could yield a more robust prediction.We retrospectively evaluated PCa patients who underwent staging [68Ga]PSMA-PET, followed by radical prostatectomy at our institution between 01.02.2016 31.07.2019. Fifty-eight cases with 15 PET/CT were identified....

To compare block sequential regularized expectation maximization (BSREM) and ordered subset (OSEM) for the detection of in-transit metastasis (ITM) malignant melanoma in digital [18F]FDG PET/CT.We retrospectively analyzed a cohort 100 PET/CT scans patients with ITM, performed between May 2017 January 2020. PET images were reconstructed both OSEM BSREM algorithms. SUVmax, target-to-background ratio (TBR), metabolic tumor volume (MTV) recorded each ITM. Differences parameters Wilcoxon...

Abstract Purpose To define the normal range and threshold values for pathologic prolapse on MRI using PICS line assess its correlation with pubococcygeal (PCL). Methods This prospective, IRB-approved study included 20 nulliparous volunteers 18 patients (POP-Q Stage ≥ 2). Organ positions (bladder, cervix, anorectal junction) relative to PCL were measured dynamic MRI. Differences in organ position compared. Receiver-operating characteristic (ROC) analysis was performed identify cutoff line....

Abstract Background Liver uptake in [ 68 Ga]Ga-PSMA-11 PET is used as an internal reference addition to clinical parameters select patients for 177 Lu]Lu-PSMA-617 radioligand therapy (RLT). Due increased demand, was replaced by 18 F]F-PSMA-1007, a more lipophilic tracer with different biodistribution and splenic suggested new reference. We compared the intra-patient distribution between F]F-PSMA-1007. Methods Fifty who underwent examinations two centers both F]F-PSMA-1007 within one year...

Objectives The aim of this study was to compare image quality, conspicuity, and endoleak detection between single-energy low-kV images (SEIs) dual-energy low-keV virtual monoenergetic (VMIs+) in computed tomography angiography the aorta after endovascular repair. Materials Methods An abdominal aortic aneurysm phantom simulating 36 endoleaks (2 densities; diameters: 2, 4, 6 mm) a medium- large-sized patient used. Each size scanned using at 80 kVp (A) 100 (B), 80/Sn150kVp for medium (C)...

Comparing mpMRI and 68Ga-PSMA-PET/MRI in primary staging of PCa investigating the value quantitative mpMRI-measurements for prediction extracapsular extension N-metastases.Patients with undergoing during January 2016 to February 2019 were retrospectively included. Two readers each on or rated extraprostatic (≥T3) regional lymph-node-metastasis (N1) a Likert-scale. A fifth reader measured tumor volume, maximum diameter, capsular contact length mpMRI. Probability was additionally calculated...

To assess the evolution of administered radiotracer activity for F-18-fluorodeoxyglucose (18F-FDG) PET/CT or PET/MR in pediatric patients (0-16 years) between years 2000 and 2021.

To compare multi-slice (MS) MRI sequences of the pelvis acquired at rest and straining to dynamic midsagittal single-slice (SS) for assessment pelvic organ prolapse (POP).This IRB-approved prospective single-center feasibility study included 23 premenopausal symptomatic patients with POP 22 asymptomatic nulliparous volunteers. was performed SS MS sequences. Straining effort, visibility organs grade were scored on both. Organ points (bladder, cervix, anorectum) measured. Differences between...

Abstract To evaluate whether a machine learning classifier can image quality of maximum intensity projection (MIP) images from F18-FDG-PET scans. A total 400 MIP with simulated decreasing acquisition time (120 s, 90 60 30 s and 15 per bed-position) using block sequential regularized expectation maximization (BSREM) beta-value 450 600 were created. was fed 283 rated “sufficient quality” 117 “insufficient quality”. The classification performance the assessed by calculating sensitivity,...

Alveolar echinococcosis is a rare parasitic disease, most frequently affecting the liver, as slow-growing tumor-like lesion. If inoperable, long-term benzimidazole therapy required, which associated with high healthcare costs and occasionally increased morbidity. The aim of our study was to determine role 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in staging patients alveolar identify quantitative imaging parameters related patient outcome and/or...

Abstract Objectives To introduce an automated computational algorithm that estimates the global noise level across whole imaging volume of PET datasets. Methods [ 18 F]FDG images 38 patients were reconstructed with simulated decreasing acquisition times (15–120 s) resulting in increasing levels, and block sequential regularized expectation maximization beta values 450 600 (Q.Clear 600). One reader performed manual volume-of-interest (VOI) based measurements liver lung parenchyma two readers...

Background: The levator ani muscle (LAM) is crucial for pelvic floor stability, yet its quantitative MRI assessment only a recent focus. Our study aims to standardize the analysis of LAM morphology within 3D Pelvic Inclination Correction System (3D-PICS). Methods: We analyzed 35 static MR datasets from nulliparous women examining pubovisceral (PVM), iliococcygeal (ICM), coccygeal (COC), and puborectal (PRM). PVM consists three origin-insertion pairs, namely puboanal (PAM), puboperineal (PPM)...

Purpose Hypophysitis occurs in up to 10% of patients treated with immune-checkpoint inhibitors (ICIs). MRI shows no abnormalities the pituitary gland one third patients. A delayed diagnosis increases risk for life-threatening adrenal crisis, underscoring need early detection. This study evaluates diagnostic accuracy FDG PET/CT detecting ICI-induced hypophysitis a cohort melanoma Materials and Methods Patients metastatic hypophysitis, who underwent 90 days before 10 after diagnosis, were...

To investigate the potential role of follow-up 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in therapy control inoperable patients with alveolar echinococcosis.In this single-center retrospective cohort study, 48 PET/CT 16 confirmed echinococcosis were analysed. FDG-uptake most active manifestation was measured (i.e., maximum standardized uptake value (SUVmax) and relation to background activity normal liver tissue (SUVratio)) compared...

The objective of this study was to assess the feasibility and accuracy a fully automated artificial intelligence (AI) powered coronary artery calcium scoring (CACS) method on ungated CT in oncologic patients undergoing 18F-FDG PET/CT.A total 100 examined between 2007 2015 were retrospectively included. All underwent PET/CT cardiac SPECT myocardial perfusion imaging (MPI) by 99mTc-tetrofosmin within 6 months. CACS manually performed non-contrast ECG-gated scans obtained from SPECT-MPI (i.e.,...

To evaluate the evolution of CT radiation dose in pediatric patients undergoing hybrid 2-[18F]fluoro-2-deoxy-D-glucose (2-[18F]FDG) PET/CT between 2007 and 2021.Data from all aged 0-18 years who underwent 2-[18F]FDG body January May 2021 were reviewed. Demographic imaging parameters collected. A board-certified radiologist reviewed scans measured image noise brain, liver, adductor muscles.294 167 children (72 females (43%); median age: 14 (IQR 10-15) years; BMI: 17.5 15-20.4) kg/m2)...