- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Medical Imaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Radiology practices and education
- Dental Radiography and Imaging
- Radiomics and Machine Learning in Medical Imaging
- Photoacoustic and Ultrasonic Imaging
- Infective Endocarditis Diagnosis and Management
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- Ultrasound in Clinical Applications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Advanced MRI Techniques and Applications
- Voice and Speech Disorders
- Congenital Diaphragmatic Hernia Studies
- Acute Myocardial Infarction Research
- Digital Radiography and Breast Imaging
- COVID-19 diagnosis using AI
- Lung Cancer Treatments and Mutations
- Myasthenia Gravis and Thymoma
- Cardiac tumors and thrombi
- MicroRNA in disease regulation
University Hospital of Zurich
2019-2025
University of Zurich
2019-2025
Kantonsspital Baden
2023-2025
Siemens Healthcare (Germany)
2016-2023
Creative Commons
2023
Prevention Institute
2021-2023
Bayer (United States)
2023
University of Lausanne
2022
Society of Interventional Radiology
2020-2022
Maastricht University
2022
The aim of this study was to evaluate the feasibility and quality ultra-high-resolution coronary computed tomography angiography (CCTA) with dual-source photon-counting detector CT (PCD-CT) in patients a high calcium load, including an analysis optimal reconstruction kernel matrix size.In institutional review board-approved study, 20 (6 women; mean age, 79 ± 10 years; body mass index, 25.6 4.3 kg/m 2 ) undergoing PCD-CCTA mode were included. Ultra-high-resolution CCTA acquired...
The aims of this study were to determine the objective and subjective image quality high-pitch computed tomography (CT) angiography aorta in clinical dual-source photon-counting detector CT (PCD-CT) compare conventional energy-integrating (EID-CT) same patients at equal radiation dose.Patients with prior thoracoabdominal acquired on third-generation EID-CT mode automatic tube voltage selection (ATVS, reference 100 kV) included. Follow-up imaging was performed a first-generation, PCD-CT...
Background An iterative reconstruction (IR) algorithm was introduced for clinical photon-counting detector (PCD) CT. Purpose To investigate the image quality and optimal strength level of a quantum IR (QIR; Siemens Healthcare) virtual monoenergetic images polychromatic (T3D) in phantom patients undergoing portal venous abdominal PCD Materials Methods In this retrospective study, noise power spectrum (NPS) measured water-filled phantom. Consecutive oncologic who underwent CT between March...
To assess the effect of ultra-high-resolution coronary CT angiography (CCTA) with photon-counting detector (PCD) on quantitative plaque characterization.
The aim of this study was to evaluate the feasibility and accuracy cardiac late enhancement (LE) scanning for extracellular volume (ECV) quantification with dual-source photon-counting detector computed tomography (PCD-CT).In institutional review board-approved study, 30 patients (mean age, 79 years; 12 women; mean body mass index, 28 kg/m2) severe aortic stenosis undergoing PCD-CT as part their preprocedural workup transcatheter valve replacement were included. scan protocol consisted a...
To develop and evaluate a low-volume contrast media protocol for thoracoabdominal CT angiography (CTA) with photon-counting detector (PCD) CT.This prospective study included consecutive participants (April-September 2021) who underwent CTA PCD of the aorta previous energy-integrating (EID) at equal radiation doses. In CT, virtual monoenergetic images (VMI) were reconstructed in 5-keV intervals from 40 to 60 keV. Attenuation aorta, image noise, contrast-to-noise ratio (CNR) measured,...
The aim of this study was to investigate the image quality, radiation dose, and accuracy virtual noncontrast images iodine quantification split-filter dual-energy computed tomography (CT) using a single x-ray source in phantom patient study.In study, objective quality were evaluated for mode tin gold filter. In dose compared thoracoabdominal CT 50 patients between standard single-energy mode. estimated by size-specific estimate. To evaluate imaging, attenuation measurements liver, spleen,...
Objective The aim of this study was to evaluate the image quality (IQ) and performance an artificial intelligence (AI)-based computer-aided detection (CAD) system in photon-counting detector computed tomography (PCD-CT) for pulmonary nodule evaluation at different low-dose levels. Materials Methods An anthropomorphic chest-phantom containing 14 nodules sizes (range, 3–12 mm) imaged on a PCD-CT conventional energy-integrating CT (EID-CT). Scans were performed with each 3 vendor-specific...
The aim of this study was to characterize image quality and determine the optimal strength levels a novel iterative reconstruction algorithm (quantum reconstruction, QIR) for low-dose, ultra-high-resolution (UHR) photon-counting detector CT (PCD-CT) lung. Images were acquired on clinical dual-source PCD-CT in UHR mode reconstructed with sharp lung kernel at different QIR (QIR-1 QIR-4) without (QIR-off). Noise power spectrum (NPS) target transfer function (TTF) analyzed cylindrical phantom....
The aim of this study was to determine the potential photon-counting detector computed tomography (PCD-CT) for radiation dose reduction compared with conventional energy-integrated CT (EID-CT) in assessment interstitial lung disease (ILD) systemic sclerosis (SSc) patients.In retrospective study, SSc patients receiving a follow-up noncontrast chest examination on PCD-CT were included between May 2021 and December 2021. Baseline scans generated dual-source EID-CT by selecting tube current-time...
Background Accurate CT attenuation and diagnostic quality of virtual noncontrast (VNC) images acquired with photon-counting detector (PCD) are needed to replace true (TNC) scans. Purpose To assess the errors image VNC from abdominal PCD compared TNC images. Materials Methods In this retrospective study, consecutive adult patients who underwent a triphasic examination July 2021 October were included. reconstructed arterial portal venous phase CT. The absolute error was measured in multiple...
Objectives: To assess the impact of low kilo-electronvolt (keV) virtual monoenergetic image (VMI) energies and iterative reconstruction on quality clinical photon-counting detector coronary CT angiography (CCTA). Methods: CCTA with PCD-CT (prospective ECG-triggering, 120 kVp, automatic tube current modulation) was performed in a high-end cardiovascular phantom dynamic flow, pulsatile heart motion, including different calcified plaques various stenosis grades 10 consecutive patients. VMI at...
Purpose To assess the accuracy of aortic valve calcium (AVC), mitral annular (MAC), and coronary artery (CAC) quantification risk stratification using virtual noncontrast (VNC) images from late enhancement photon-counting detector CT as compared with true images. Materials Methods This retrospective, institutional review board–approved study evaluated patients undergoing between January September 2022. VNC were reconstructed cardiac scans at 60, 70, 80, 90 keV quantum iterative...
The purpose of this study was to assess image noise, spatial resolution, lesion detectability, and the dose reduction potential a proprietary third-generation adaptive statistical iterative reconstruction (ASIR-V) technique.A phantom representing five different body sizes (12-37 cm) contrast-detail containing lesions low-contrast levels (5-20 HU) three (2-6 mm) were deployed. Both phantoms scanned on 256-MDCT scanner at six radiation doses (1.25-10 mGy). Images reconstructed with filtered...
We evaluated the accuracy of coronary artery calcium (CAC) scoring on a dual-source photon-counting detector CT (PCD-CT). An anthropomorphic chest phantom underwent ECG-gated sequential scanning PCD-CT at 120 kV with four radiation dose levels (CTDIvol, 2.0–8.6 mGy). Polychromatic images (T3D) and virtual monoenergetic (VMI), from 60 to 75 keV without quantum iterative reconstruction (no QIR) QIR strength 1–4, were reconstructed. For reference, same was scanned conventional...
The aim of this study was to assess the accuracy virtual noncontrast (VNC) images liver in a phantom and patients using dual-source photon-counting detector computed tomography (PCD-CT).An anthropomorphic abdominal with insert containing parenchyma (1.4 mgI/mL) 19 lesions (iodine content 0-5 imaged on clinical PCD-CT (tube voltage 120 kV) dual-energy mode energy-integrating (EID) CT combinations, 80/Sn150 kV, 90/Sn150 100/Sn150 kV). Rings fat-equivalent material were added emulate 3 sizes...
Objectives To assess image noise, diagnostic performance, and potential for radiation dose reduction of photon-counting detector (PCD) computed tomography (CT) with quantum iterative reconstruction (QIR) in the detection hypoattenuating hyperattenuating focal liver lesions compared energy-integrating (EID) CT. Materials Methods A medium-sized anthropomorphic abdominal phantom parenchyma (diameter, 5–10 mm; from −30 HU to +90 at 120 kVp) was used. The imaged on ( a ) third-generation...
Objectives The aim of this study was to evaluate the optimal energy level virtual monoenergetic images (VMIs) from photon-counting detector computed tomography (CT) for detection liver lesions as a function phantom size and radiation dose. Materials Methods An anthropomorphic abdominal with parenchyma imaged on dual-source CT at 120 kVp. Five hypoattenuating lesion-to-background contrast difference −30 HU −45 3 hyperattenuating +30 +90 were used. lesion diameter 5–10 mm. Rings fat-equivalent...
Epicardial Adipose Tissue Attenuation and Fat Index: Phantom Study In Vivo Measurements With Photon-Counting Detector CTVictor Mergen, MD1, Emanuel Ried, Thomas Allmendinger, PhD2, Sartoretti, BMed1, Kai Higashigaito, Robert Manka, MD1,3, Andre Euler, Hatem Alkadhi, MD, MPH1 Matthias Eberhard, MD1Audio Available | Share
To evaluate the performance of virtual non-contrast images (VNC) compared to true (TNC) in photon-counting detector computed tomography (PCD-CT) for evaluation lung parenchyma and emphysema quantification.
Purpose The aim of this study was to evaluate the impact contrast enhancement and different virtual monoenergetic image energies on automatized emphysema quantification with photon-counting detector computed tomography (PCD-CT). Material Methods Sixty patients who underwent contrast-enhanced chest CT a first-generation, clinical dual-source PCD-CT were retrospectively included. Scans performed in multienergy (QuantumPlus) mode at 120 kV weight-adjusted intravenous agent. Virtual noncontrast...