A5101999839- Mitochondrial Function and Pathology
- Bioinformatics and Genomic Networks
- Natural product bioactivities and synthesis
- Signaling Pathways in Disease
- Phytochemical compounds biological activities
- Molecular Biology Techniques and Applications
- Herbal Medicine Research Studies
- S100 Proteins and Annexins
- Ubiquitin and proteasome pathways
- Traditional Chinese Medicine Studies
- Traditional Chinese Medicine Analysis
- Respiratory and Cough-Related Research
- Gene expression and cancer classification
- Oral and gingival health research
- Medical and Biological Ozone Research
- Endometriosis Research and Treatment
- Piperaceae Chemical and Biological Studies
- Nitric Oxide and Endothelin Effects
- Botanical Studies and Applications
- Oral microbiology and periodontitis research
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Chromatography in Natural Products
- Plant-based Medicinal Research
- ATP Synthase and ATPases Research
Simcere Pharmaceutical (China)
2022
Shandong University of Traditional Chinese Medicine
2016-2018
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2018
Shanghai University of Traditional Chinese Medicine
2018
Analysis and Testing Centre
2017
Shandong University
2016
China Academy of Chinese Medical Sciences
2016
Network pharmacology-based identification of key pharmacological pathways Yin–Huang–Qing–Fei capsule acting on chronic bronchitis Guohua Yu,1,2,* Yanqiong Zhang,2,* Weiqiong Ren,3 Ling Dong,1 Junfang Li,2,4 Ya Geng,2,5 Yi Zhang,2 Defeng Li,2 Haiyu Xu,2 Hongjun Yang2 1School Chinese Materia Medica, Beijing University Medicine, 2Institute China Academy Medical Sciences, Beijing, 3The First Affiliated Hospital Hunan Traditional Changsha, 4School Tianjin Tianjin, 5School Basic Shandong Jinan,...
QiXueHe Capsule (QXHC) is a Chinese patent drug that extensively used for the treatment of menstrual disorders. However, its underlying pharmacological mechanisms have not been fully elucidated. A list QXHC putative targets were predicted using MetaDrug. An interaction network links between and known therapeutic disorders was constructed. candidate also identified via calculating topological feature values nodes in network. Additionally, molecular docking simulation performed to determine...
ABSTRACT Mitochondria are important for energy production and cardiomyocyte homeostasis. OMA1, a metalloendopeptidase, initiates the proteolytic process of fusion-allowing protein OPA1, to deteriorate mitochondrial structure function. In this study, mouse embryonic fibroblasts (MEFs) neonatal cardiomyocytes (NMCMs) subjected hypoxia-reperfusion injury (HRI) and/or H2O2 were used mimic oxidative stress in heart following ischemia-reperfusion (IRI). vitro experiments demonstrated that HRI or...
Traditional Chinese medicine (TCM) preparations have significant effects on some refractory diseases; however, these compositions are complex and their mechanisms unknown. Identification of the active components in is essential. The mortality rate for heart failure (HF) has been increasing recent years, myocardial dysfunction (MD) proved to be pathological basis HF. Yixinshu Capsule (YXSC) a multi-component oral drug with therapeutic However, key still unclear. In this study, YXSC intestinal...
Oxidative stress initiates harmful cellular responses, such as DNA damage and protein denaturation, triggering a series of cardiovascular disorders. Systematic investigations the transcription factors (TFs) involved in oxidative can help reveal underlying molecular mechanisms facilitate discovery effective therapeutic targets related diseases. In this study, an integrated strategy which RNA-seq-based transcriptomics techniques newly developed concatenated tandem array consensus TF response...
In this study, a ultra-high-pressure liquid chromatography coupled with linear ion trap-Orbitrap tandem mass spectrometry (UHPLC-LTQ-Orbitrap-MS/MS) method was developed to analyze the chemical components in Citrus aurantium. C. aurantium were extracted 75% methanol, and we applied Thermo Scientific BDS Hypersil C₁₈ column (2.1 mm×150 mm, 2.4 μm) UHPLC analysis acetonitrile-water (containing 0.1% formic acid) gradient as mobile phase. Elutes then detected by ESI-LTQ-Orbitrap-MS/MS. A total...
Gingivitis is an inflammatory disease that affects gingival tissues through a microbe-immune interaction. Huanglian Jiedu decoction (HLJD) used traditionally for clearing and detoxifying in China, which had been reported to possess many pharmacological effects. Rat inflammation model was established by lipopolysaccharide (LPS) injection 3 consecutive days, HLJD given gavage before LPS injection. After days rats were sacrificed tissue samples evaluated. Serum cytokine levels such as...
Seven compounds, including two flavanones, dihydrokaempferol ( 1 ) and naringenin 2 ), five terpenoids, boscartol A 3 3,7-dioxo-tirucalla-8,24-dien-21-oic acid 4 3α-acetoxyl-7-oxo-tirucalla-8,24-dien-21-oic 5 11-keto-β-boswellic 6 acetyl-11-keto-boswellic 7 have been purified by high-speed counter-current chromatography (HSCCC) from olibanum. For the separation, 250 mg of crude extract, 3.1 (95.2% purity), 2.7 (96.1% 9.1 (96.7% 4.5 (95.3% 5.4 (96.3% 48.1 (96.8% 45.5 (98.1% purity) were...
To analyze the prescription rules of preparations containing Crataegi Fructus in drug standards People's Republic China Ministry Public Health-Chinese Patent Drug(hereinafter referred to as Chinese patent drug), and provide some references for clinical application research development new medicines. Based on TCMISS(V2.5), prescriptions were collected build database; association rules, frequency statistics other data mining methods used disease syndrome, common compatibility rules. There a...
This research firstly establishes the oxidative damage model of H9c2 induced by H2O2 and screens concentration range intestines absorption liquid Qi benefiting blood circulation activating formula which possess external myocardium protection function. Then, thesis chooses 4 dosages to conduct experiments：examining function on provide reference for clinical prevention curing relative heart diseases stress injury; as well examining cardiac muscle cell vigour, cellular morphology, SOD, MDA...
Abstract Targeting DNA damage response (DDR) pathways has been proposed as an approach for amplifying tumor-specific replicative lesions. RAD51 plays a central role in the DDR pathway, and thus represents promising anti-tumor target. We here report discovery of series next generation inhibitors that can prevent foci formation particularly, pre-clinical candidate molecule SCR-6992 with potent efficacies desirable development drug properties. exhibits remarkable anti-proliferative potency...