A5100674074- Traditional Chinese Medicine Analysis
- Plant-based Medicinal Research
- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Chromatography
- Metabolism and Genetic Disorders
- Advanced Proteomics Techniques and Applications
- Mass Spectrometry Techniques and Applications
- Medicinal Plants and Neuroprotection
- Glycosylation and Glycoproteins Research
- Antioxidants, Aging, Portulaca oleracea
- Chromatography in Natural Products
- RNA regulation and disease
- Acupuncture Treatment Research Studies
- Alkaloids: synthesis and pharmacology
- Phytochemical compounds biological activities
- Plant Growth Enhancement Techniques
- Ginseng Biological Effects and Applications
- Neurological Disease Mechanisms and Treatments
- Bioactive Natural Diterpenoids Research
- Pesticide Residue Analysis and Safety
- Gastrointestinal motility and disorders
- Berberine and alkaloids research
- Drug-Induced Adverse Reactions
- Pharmaceutical studies and practices
- Neuroinflammation and Neurodegeneration Mechanisms
Center for Drug Evaluation and Research
2017-2020
United States Food and Drug Administration
2017-2020
Analysis and Testing Centre
2017
Nanyang Technological University
2016
Chinese Academy of Sciences
2012-2015
Changchun Institute of Applied Chemistry
2012-2015
University of Chinese Academy of Sciences
2012-2014
Hunan University
2009-2010
State Key Laboratory of Chemobiosensing and Chemometrics
2009-2010
In the present work, microwave heating was applied to preparation of kaempferol molecularly imprinted polymer (MIP) microspheres, resulting in much shorter polymerization times. The MIP microspheres were demonstrated with a narrow diameter distribution 6-9 μm and spherical shape. average 50 8 μm. results morphology observation, static adsorption performance selectivity all superior that MIPs prepared by conventional heating. imprinting efficiency 5.0 4.2, which respectively. used as sorbent...
Abstract In this study, an extend application was developed to in situ analyze the herbal pieces of Aconitum plants by Direct Analysis Real Time Mass Spectrometry (DART‐MS). Nearly all aconitine‐type alkaloids can be desorbed and ionized method, including diester diterpenoid aconitines (DDAs), monoester (MDAs) some other aconitines. The spectra analysis for aconitum are similar with that their extracts. Radix Aconiti Kusnezoffii distinguished from each intensity differences character...
A recently developed synchronous precursor selection (SPS) mass spectrometry to the third (MS3) protocol enables more accurate multiplexed quantification of proteins/peptides using tandem tags (TMT) through comparison reporter ion intensities at MS3 level. However, challenges still exist for TMT-based simultaneous and identification intact glycopeptides due inefficient peptide backbone fragmentation when collision-induced dissociation (CID). To overcome this limitation, here we report an...
Abstract Bulleyaconitine A (BLA) from Aconitum bulleyanum plants is usually used as anti‐inflammatory drug in some Asian countries. It has a variety of bioactivities, and at the same time toxicities. Since bioactivities toxicities BLA are closely related to its metabolism, metabolites metabolic pathways rat liver microsomes were investigated by HPLC–MS n . In this research, 12 identified according results HPLC‐MS data relevant literature. The showed that there multiple microsomes, including...
RATIONALE Prostaglandin E2 is an important biomarker in many biological systems. The development of sensitive and reliable analytical methods for monitoring PGE2 contents various samples great interest. Here we developed improved method evaluating the enzyme activity screening COX-2 inhibitors using ultrahigh-performance liquid chromatography/tandem mass spectrometry (UPLC/MS/MS) combined with derivatization. METHODS Girard's reagent-T was used as derivatization reagent reaction conditions...
Seven compounds, including two flavanones, dihydrokaempferol ( 1 ) and naringenin 2 ), five terpenoids, boscartol A 3 3,7-dioxo-tirucalla-8,24-dien-21-oic acid 4 3α-acetoxyl-7-oxo-tirucalla-8,24-dien-21-oic 5 11-keto-β-boswellic 6 acetyl-11-keto-boswellic 7 have been purified by high-speed counter-current chromatography (HSCCC) from olibanum. For the separation, 250 mg of crude extract, 3.1 (95.2% purity), 2.7 (96.1% 9.1 (96.7% 4.5 (95.3% 5.4 (96.3% 48.1 (96.8% 45.5 (98.1% purity) were...