A5100340187- Urinary Bladder and Prostate Research
- Prostate Cancer Diagnosis and Treatment
- Pelvic floor disorders treatments
- Urological Disorders and Treatments
- Hormonal and reproductive studies
- Urinary Tract Infections Management
- Cancer, Lipids, and Metabolism
- Prostate Cancer Treatment and Research
- Migraine and Headache Studies
- Urinary and Genital Oncology Studies
- Cancer Cells and Metastasis
- Bladder and Urothelial Cancer Treatments
- Urologic and reproductive health conditions
- Pelvic and Acetabular Injuries
- Graphene and Nanomaterials Applications
- Dietary Effects on Health
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Connexins and lens biology
- Gastrointestinal Tumor Research and Treatment
- Bone and Joint Diseases
- Vagus Nerve Stimulation Research
- Ocular and Laser Science Research
- Ubiquitin and proteasome pathways
- Circular RNAs in diseases
- Neonatal Respiratory Health Research
Shanghai Jiao Tong University
2012-2025
Shanghai Ninth People's Hospital
2012-2025
Shanghai University of Medicine and Health Sciences
2024
Second Affiliated Hospital of Xi'an Jiaotong University
2019-2024
Third Affiliated Hospital of Southern Medical University
2023
Second Affiliated Hospital of Nanjing Medical University
2022
Beijing University of Chinese Medicine
2021
Karolinska Institutet
2019
University of Nevada, Reno
2018
Ningxia Medical University
2012
We compared plasmakinetic resection with holmium laser enucleation of the prostate for treatment benign prostatic hyperplasia by analyzing 2-year followup data from a prospective randomized clinical trial.A total 280 patients were randomly treated or prostate. Perioperative and postoperative outcome obtained during followup.No significant differences between 2 surgical groups observed in preoperative data. Both displayed improvements after surgery. However, we identified no I-PSS...
Abstract To predict the pathological subdiagnosis of benign prostatic hyperplasia (BPH‐PS) with overarching aim mitigating finasteride overtreatment, we conducted a study integrating clinical, pathological, and radiomic data from BPH patients at our center. The comprised retrospective analysis prospective cohort undergoing pharmacological treatment for six months. Sixty (mean age: 68.5 ± 7.1 years) 360 histopathological whole‐slide images (WSIs) were included in cohort. Three gland...
Objective To evaluate the efficacy and safety of a wearable, smartphone‐controlled, rechargeable transcutaneous tibial nerve stimulation (TTNS) device in patients with overactive bladder (OAB). Patients Methods This multicentre, prospective, single‐blind, randomised clinical trial included eligible OAB symptoms who were randomly assigned to group or sham group. The primary outcome was change from baseline voiding frequency/24 h after 4 weeks treatment. secondary outcomes changes diary...
Purpose: To evaluate the long-term and flexible cystourethroscopy results of holmium laser enucleation prostate (HoLEP) to compare them with those plasmakinetic resection (PKRP). Methods: In follow-up, variables, including international prostatic symptomatic score, quality life scores, maximum flow rate (Qmax), index erectile function (IIEF), adverse events, need for retreatment, were specifically assessed. One hundred twenty-two HoLEP 119 PKRP initial 280 patients included in this study...
Key points Studies of urothelial cells, bladder sheets or lumens filled bladders have suggested that mediators released from urothelium into suburothelium (SubU)/lamina propria (LP) activate mechanisms controlling detrusor excitability. None these approaches, however, has enabled direct assessment availability at SubU/LP during filling. We developed an ex vivo mouse preparation with intact and but no detrusor, which allows access to the surface Pressure–volume measurements filling...
The dysregulation of circular RNAs (circRNAs) is implicated in the pathogenesis prostate cancer (PCa). However, underlying mechanisms by which hsa_circ_0003768 (circPDHX) contributes to PCa remain elusive. differentially expressed circRNAs between and normal tissues were identified Gene Expression Omnibus dataset. association circPDHX miR-378a-3p expression with clinicopathological parameters prognosis patients was analyzed fluorescence situ hybridization Cancer Genome Atlas...
The aim of the present study was to evaluate oxytocin and benign prostatic hyperplasia (BPH), cell signalling mechanism. Investigation performed in patients about correlation between level BPH. Mice were injected with or antagonist for 2 weeks prostate morphology studied after their sacrifice. Furthermore, vitro experiments effect through MEK/ERK/RSK pathway. Oxytocin significantly elevated serum tissue BPH, a positive volume indicated. In animal experiments, enlargement observed...
Abstract Background Fertility in men with hypospadias may be affected due to anatomical, surgical, or etiological factors and associated conditions. is further influenced by psychosocial genetic factors, often shared within families. Objective To evaluate fertility born assess confounding familial factors. Materials methods A population‐based cohort of 1.2 million Sweden 1964‐1998, identified through national demographic healthcare registers. Associations between (a) being a biological...
<i>Objectives:</i> We report our prospective clinical result of transurethral resection in saline (TURIS) versus monopolar the prostate (TURP) system treating large-volume benign prostatic hyperplasia (BPH). <i>Patients and Methods:</i> Patients with BPH (volume >50 ml) were enrolled study. An intravenous device was used for serum sodium hemoglobin tests to monitor alteration. All acute complications noted. followed up at least 6 months. <i>Results:</i>...
The role of high-fat diet (HFD) induced gut microbiota alteration and Ghrelin as well their correlation in benign prostatic hyperplasia (BPH) were explored our study. was analyzed by 16s rRNA sequencing. levels serum, along with receptor prostate tissue mice patients BPH measured. effect on cell proliferation, apoptosis, induction explored. Our results indicated that have the highest ratio Firmicutes Bacteroidetes HFD, level serum significantly increased compared control. Elevated content...
Purpose: We modified the conventional morcellation procedure for holmium laser enucleation of prostate (HoLEP), and its outcomes are presented in this article. Materials Methods: As 395 patients were included, was performed first 100 cases (group 1, 1–100), an improved used last 2, 296–395). The process has three steps to execute. time, collected tissue weight, rate, associated complications recorded. Results: tissue-resected weight similar between group 1 (60.7±33.9 g) 2 (62.4±36.8 g). mean...
Purpose: To compare the efficacy and safety of plasma kinetic enucleation prostate (PKEP) with holmium laser (HoLEP) for treatment benign prostatic hyperplasia (BPH). Methods: A total 160 patients indications surgical BPH were randomly assigned to receive either PKEP or HoLEP prospectively. Baseline characteristics, perioperative data, postoperative outcomes recorded. One hundred twenty-six (78.75%) (PKEP 64 vs 62) completed 3-year follow-up assessment. Results: Patients in both groups had...
Stromal cells play a decisive role in regulating tumor progression. In this study, we assessed the significance of normal prostate-derived stromal (PSCs) prostate cancer development. An vivo s.c. model was established as follows: Group 1, DU145 alone; 2, + PSCs; 3, alone injected into pre-castrated mice; and 4, PSCs mice. Following injection, tumors were only detectable first two groups, with more aggressive growth 2 than 1 (P < 0.05). Immunohistochemical analysis revealed significantly...
Aim To evaluate the efficacy and safety of intravesical electrical stimulation (IVES) performed with a novel device in patients underactive bladder (UAB). Patients Methods This was multicentre, prospective, single‐blind, randomized controlled clinical trial UAB China. Eligible were randomly assigned 1:1 ratio to receive conventional IVES ( n = 38) or an open circuit 38). The primary measure change from baseline post‐void residual urine volume (PVR) after 4 weeks treatment. Secondary measures...
The incidence of benign prostatic hyperplasia increases among obese individuals, but few studies have fully explained the underlying mechanisms. Adiponectin has drawn much attention in recent years due to its protective role obesity-related diseases. Here we aimed investigate possible molecular mechanisms and clinical significance adiponectin relation hyperplasia.We analyzed data from 98 Chinese men, including 48 BPH cases 50 controls a case-control study. Then, utilized tissue microarray...
We report here testosterone deficiency in diet-induced hypercholesterolemic mice. attempted to compare the liver protein profiles between and normal mice by using technology of proteomics. Protein extractions from livers were separated two-dimensional electrophoresis gels analysed with image analysis software 2D Elite 4.0. The differentially expressed proteins identified primarily comparing reference gel images SWISS 2DPAGE database then confirmed peptide mass fingerprinting. Sixteen spots...