A5059802740- Hepatitis B Virus Studies
- Hepatitis C virus research
- DNA Repair Mechanisms
- Genomics and Chromatin Dynamics
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Urinary Bladder and Prostate Research
- Animal Virus Infections Studies
- Genomics and Phylogenetic Studies
- Bacteriophages and microbial interactions
- Cancer-related molecular mechanisms research
- Catalysis and Oxidation Reactions
- Prostate Cancer Diagnosis and Treatment
- Smart Grid and Power Systems
- Semiconductor materials and devices
- Catalytic Processes in Materials Science
- Advanced Nanomaterials in Catalysis
- Hemodynamic Monitoring and Therapy
- Environmental DNA in Biodiversity Studies
- Acute Kidney Injury Research
- Dermatological and Skeletal Disorders
- Insect symbiosis and bacterial influences
- Thermoregulation and physiological responses
- Electrochemical sensors and biosensors
- Fungal and yeast genetics research
People's Hospital of Bishan District
2024
Nanjing Agricultural University
2014-2023
Suzhou Research Institute
2023
Harbin Medical University
2022
Second Affiliated Hospital of Harbin Medical University
2022
Second Affiliated Hospital of Fujian Medical University
2015-2022
Fujian Medical University
2015-2022
Nanjing Health and Health Commission
2021
Zhejiang Provincial People's Hospital
2019
Zhejiang University
2001-2018
Abstract N 6-methyladenosine (m6A), the most prevalent mRNA modification in eukaryotes, is an emerging player of gene regulation at transcriptional and translational levels. Here, we explored role m6A response to low temperature Arabidopsis (Arabidopsis thaliana). Knocking down adenosine methylase A (MTA), a key component complex, by RNA interference (RNAi) led drastically reduced growth temperature, indicating critical chilling response. Cold treatment overall level mRNAs especially 3′...
Abstract Background Direct analogs of chemically modified bases that carry important epigenetic information, such as 5-methylcytosine (m5C)/5-methyldeoxycytosine (5mC), 5-hydroxymethylcytosine (hm5C)/5-hydroxymethyldeoxycytosine (5hmC), and N 6 -methyladenosine (m6A)/ -methyldeoxyadenosine (6mA), are detected in both RNA DNA, respectively. The base 4 -acetylcytosine (ac4C) is well studied RNAs, but its presence roles cellular DNA have not been explored. Results Here, we demonstrate the...
The remodeling of transcriptome, epigenome, proteome, and metabolome in hybrids plays an important role heterosis. N(6)-methyladenosine (m 6 A) methylation is the most abundant type post-transcriptional modification for mRNAs, but pattern inheritance from parents to potential impact on heterosis are largely unknown. We constructed transcriptome-wide mRNA m A maps Arabidopsis thaliana Col-0 Landsberg erecta (Ler) their reciprocal F 1 hybrids. Generally, tends be conserved between accessions....
The regulatory roles of RNA splicing in plant immunity are emerging but still largely obscure. We reported previously that Phytophthora pathogen effector Avr3c targets a soybean protein SKRP (serine/lysine/arginine-rich protein) to impair basal by regulating host pre-mRNA alternative splicing, while the biochemical nature remains unknown. Here, using Arabidopsis as model, we studied mechanism and immunity. AtSKRP confers impaired against capsici associates with spliceosome component PRP8...
This study aimed to survey the geriatric nursing competencies of clinical staff in Chongqing City, China, and provide suggestions enhance these competencies. was conducted 204 hospitals Southwest China from December 24, 2022 January 7, 2023. The "Geriatric Nursing Competence Clinical Nurse Investigation Tool" used explore factors that influence nurses' via stratified sampling. by distributing collecting questionnaires through online platform Wenjuanxing. A total 10,692 nurses answered...
Carbon-encapsulated cobalt nanoparticles are prepared over a range of temperaturesand partial pressures by CVD from cyclohexane on substrates consisting ground powders SiO2 impregnated with Co(NO3)2 and (NH4)2Mo2O7. The encapsulated freed the incorporated molybdenum treating deposition product aqueous hydrofluoric acid. Extracted material is dispersed in ethanol deposited carbon-coated grid prior to investigation high-resolution TEM.
Background: Focal segmental glomerulosclerosis (FSGS) is a type of nephrotic syndrome leading to end-stage renal disease, and this study aimed explore the hub genes pathways associated with FSGS identify potential diagnostic therapeutic targets. Methods: We downloaded microarray datasets GSE121233 GSE129973 from Gene Expression Omnibus (GEO) database. The comprise 25 samples normal samples. differential expression (DEGs) were identified using R package "limma". Ontology (GO) function Kyoto...
Summary Deciphering the complex cellular behaviours and advancing biotechnology applications of filamentous fungi increase requirement for genetically manipulating a large number target genes. The current strategies cannot cyclically coedit multiple genes simultaneously. In this study, we firstly revealed existence diverse homologous recombination (HR) types in marker‐free editing fungi, then, demonstrated that sgRNA efficiency‐mediated competitive inhibition resulted low integration genetic...
Here, we aimed to clone and identify the GmIMT1 gene related salt stress response in soybean.The full-length cDNA sequence of was amplified soybean using degenerate primers Mesembrythmum crystallium.To understand response, cloned sequenced.Then, expression vectors were constructed, introduced into model plant Arabidopsis thaliana through Agrobacterium mediated transformation, tolerance analyzed transgenic plants.In addition, patterns analyzed.The examined different organs (roots, leaves,...
The China southern power grid is now the only long-distance and huge capacity system with AC DC transmission lines in parallel China. reliability economic evaluation of it carried out based on software package TPLAN. By calculating indices, we get an overview grid, draw conclusion that its severity grade Grade 2. area load bus Guangdong province most unsubstantial part grid. In order to improve should pay special attention improving first. confirmed by analysis concept CCDF. Once algorithm...
In the previous studies on modeling conduit systems, system is often regarded as a single with rigid water hammer, effect of elasticity and interaction complex are neglected. this paper, versatile model proposed implemented by program interface function PSASP (developed CHINA EPRI). The based characteristic method combining numbering according to its topological structure. Thus, can be applied in any systems. On basis above work, different models power transient stability studied through...
Aim: We explored the concentrations of urinary neutrophil gelatinase-associated lipocalin (NGAL) in healthy adults Jiangsu region Eastern China and established a reference interval using latex-enhanced immunoturbidimetry to provide important guidelines for interpretation application NGAL clinical practice. Methods: In total, 1970 eligible subjects from four regions were included this study. The levels measured an AU5800 automatic biochemical analyzer with its matched reagents. was one-sided...
In the present work, we undertook complete mitochondrial genome sequencing of an important laryngeal cancer model inbred rat strain for first time. The total length mitogenome was 16,308 bp. It harbored 13 protein-coding genes, two ribosomal RNA 22 transfer and one non-coding control region (D-loop region). mutation events were also reported.