A5077881798- Phagocytosis and Immune Regulation
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Chronic Lymphocytic Leukemia Research
- Cancer Mechanisms and Therapy
- Adenosine and Purinergic Signaling
- Thermal Regulation in Medicine
- Pharmacological Effects of Natural Compounds
- Medical Research and Treatments
- Traditional Chinese Medicine Studies
- Urinary Bladder and Prostate Research
- Advanced Glycation End Products research
- Urinary Tract Infections Management
- Acupuncture Treatment Research Studies
- Bladder and Urothelial Cancer Treatments
- Mathematical Biology Tumor Growth
- Autophagy in Disease and Therapy
- Cell Adhesion Molecules Research
- Pancreatic function and diabetes
- Microbial Fuel Cells and Bioremediation
- Urological Disorders and Treatments
- Inflammatory Bowel Disease
- Advanced Queuing Theory Analysis
- Pelvic floor disorders treatments
- Anorectal Disease Treatments and Outcomes
State Key Laboratory of Food Science and Technology
2025
State Key Laboratory of Food Nutrition and Safety
2025
Tianjin University of Science and Technology
2025
Women's Hospital, School of Medicine, Zhejiang University
2023
Second Affiliated Hospital of Nanjing Medical University
2020-2022
Hebei Agricultural University
2022
Institute of Food Science and Technology
2022
Jiangxi University of Traditional Chinese Medicine
2021
Health Commission of Anhui Province
2021
MRC Laboratory of Molecular Biology
2008
SUPERFAMILY provides structural, functional and evolutionary information for proteins from all completely sequenced genomes, large sequence collections such as UniProt. Protein domain assignments over 900 genomes are included in the database, which can be accessed at http://supfam.org/. Hidden Markov models based on Structural Classification of Proteins (SCOP) definitions superfamily level used to provide structural annotation. We recently produced a new model library SCOP 1.73. Family also...
Bacterial cellulose (BC) is a nanocellulose produced by bacteria, formed glucose units linked through β-1,4 glycosidic bonds. It features three-dimensional network structure, superior water retention capacity, high porosity, and outstanding biocompatibility, among other notable characteristics. Komagataeibacter xylinus was the predominant strain used for BC production. The CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR associate-protein 9)-mediated gene editing...
Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal malignancy because of its aggressive nature and the paucity effective treatment options. Almost all registered drugs have proven ineffective in addressing needs patients with PDAC. This is result poor understanding unique tumor-immune microenvironment (TME) To identify druggable regulators immunosuppressive TME, we performed kinome- membranome-focused CRISPR screening using orthotopic PDAC models. Our data showed that...
Interstitial cystitis (IC) is a clinical syndrome characterized by frequency, urgency, and bladder pain or pelvic pain; however, the underlying pathophysiological mechanisms diagnostic markers are unknown. In this study, microbiome metabolome analysis were used to explain urine signatures of IC patients. Urine samples from 20 patients 22 control groups analyzed using 16S rRNA sequence liquid chromatography coupled with mass spectrometry. Four opportunistic pathogen genera, including...
Diabetic cystopathy (DCP) is a chronic complication of diabetes mainly within the submucosal and muscular layers bladder due to hyperglycemia-induced ischemia. As no effective therapies are currently available, administration optimized mesenchymal stem cells (MSCs) provides potential treatment DCP. Thus far, new strategy, such as genetic modification MSCs, has been developed shown promising outcomes various disorders. This study was conducted using integrin-linked kinase (ILK) gene-modified...
The hyphenation of ion mobility spectrometry with high-resolution mass has been widely used in the characterization various metabolites. Nevertheless, such a powerful tool remains largely unexplored natural products research, possibly mainly due to lack available compounds. To evaluate ability collision cross-sections (CCSs) characterizing compounds, especially isomeric products, here we measured and compared traveling-wave IMS-derived nitrogen CCS values for 75 marine-derived aphidicolanes....
Ulcerative colitis (UC) is a chronic nonspecific intestinal inflammatory disease with unclear etiology occurring in the colonic mucosa. Its clinical manifestations are characterized by recurrent abdominal pain, diarrhea, mucous pus, and blood stool. The severity of varies, itis high recurrence rate. Because its long course disease, easy to relapse, protracted difficult recover, seriously affect quality life, increase economic burden patients society, even risk developing cancer, it has...
<div>Abstract<p>Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal malignancy because of its aggressive nature and the paucity effective treatment options. Almost all registered drugs have proven ineffective in addressing needs patients with PDAC. This is result poor understanding unique tumor–immune microenvironment (TME) To identify druggable regulators immunosuppressive TME, we performed kinome- membranome-focused CRISPR screening using orthotopic PDAC models. Our...
<p>Supplementary Figure S1. In vivo CRISPR screens to identify critical drivers of immune evasion; Supplementary S2. Effects Ripk2 depletion on tumor growth; S3. RIPK2 is overexpressed in human and mouse PDAC tissues; S4. Ablation disrupts the desmoplastic TME; S5. modulates profile impairs anti-tumor T cell response; S6. restricts activation effector states CD8+ cells by impairing antigen presentation; S7. promotes MHC-I trafficking lysosomes via NBR1; S8. ubiquitination NBR1-mediated...
<div>Abstract<p>Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal malignancy because of its aggressive nature and the paucity effective treatment options. Almost all registered drugs have proven ineffective in addressing needs patients with PDAC. This is result poor understanding unique tumor–immune microenvironment (TME) To identify druggable regulators immunosuppressive TME, we performed kinome- membranome-focused CRISPR screening using orthotopic PDAC models. Our...
<div>Abstract<p>Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal malignancy because of its aggressive nature and the paucity effective treatment options. Almost all registered drugs have proven ineffective in addressing needs patients with PDAC. This is result poor understanding unique tumor–immune microenvironment (TME) To identify druggable regulators immunosuppressive TME, we performed kinome- membranome-focused CRISPR screening using orthotopic PDAC models. Our...
<p>Supplementary Figure S1. In vivo CRISPR screens to identify critical drivers of immune evasion; Supplementary S2. Effects Ripk2 depletion on tumor growth; S3. RIPK2 is overexpressed in human and mouse PDAC tissues; S4. Ablation disrupts the desmoplastic TME; S5. modulates profile impairs anti-tumor T cell response; S6. restricts activation effector states CD8+ cells by impairing antigen presentation; S7. promotes MHC-I trafficking lysosomes via NBR1; S8. ubiquitination NBR1-mediated...
<p>Supplementary Figure S1. In vivo CRISPR screens to identify critical drivers of immune evasion; Supplementary S2. Effects Ripk2 depletion on tumor growth; S3. RIPK2 is overexpressed in human and mouse PDAC tissues; S4. Ablation disrupts the desmoplastic TME; S5. modulates profile impairs anti-tumor T cell response; S6. restricts activation effector states CD8+ cells by impairing antigen presentation; S7. promotes MHC-I trafficking lysosomes via NBR1; S8. ubiquitination NBR1-mediated...