A5100329695- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Drug Solubulity and Delivery Systems
- Protein purification and stability
- Energetic Materials and Combustion
- Analytical Methods in Pharmaceuticals
- Advanced Drug Delivery Systems
- Surfactants and Colloidal Systems
- Phenothiazines and Benzothiazines Synthesis and Activities
- Composite Structure Analysis and Optimization
- Enzyme Structure and Function
- Structural Analysis and Optimization
- Microencapsulation and Drying Processes
- Crystal structures of chemical compounds
- Analytical Chemistry and Chromatography
- Medicinal plant effects and applications
- Metal and Thin Film Mechanics
- Force Microscopy Techniques and Applications
- Natural product bioactivities and synthesis
- Physics of Superconductivity and Magnetism
- Powder Metallurgy Techniques and Materials
- Diamond and Carbon-based Materials Research
- Berberine and alkaloids research
- Cavitation Phenomena in Pumps
University of Minnesota
2016-2025
Zhengzhou Institute of Emerging Industrial Technology
2025
Henan University
2025
Gree (China)
2020-2024
Purple Mountain Laboratories
2024
Nanjing University
2021-2024
Liaoning Shihua University
2024
Shenyang Aerospace University
2023-2024
Shanghai Jiao Tong University
2024
State Key Laboratory on Integrated Optoelectronics
2023
An analysis of compiled literature nanoindentation contact hardness (<italic>H</italic><sub>c</sub>) and elastic modulus (<italic>E</italic>) values molecular crystals revealed a wide range mechanical properties (0.001–1.80 GPa for <italic>H</italic><sub>c</sub> 0.27–46.8 <italic>E</italic>).
Understanding the structural origins of diverse mechanical behaviors organic crystals is critical for designing functional materials a number technological applications. To facilitate this effort, we have examined two polymorphs structurally rigid molecule, coumarin. Surprisingly, form I are highly elastic while II two-dimensional (2D) plastic and twistable. The strikingly different corroborate with respective prevailing mechanisms, i.e., high elasticity enabled by an interlocked layer...
ABSTRACT In order to explore a novel method for the treatment of drug abuse, we evaluated effect chronic deep brain stimulation (DBS) rat nucleus accumbens (NAc) on morphine reinforcement, using DBS apparatus and an implant developed. Thirty‐two adult rats weighing 240–260 g were divided into three groups, which included group ( n = 10, administration surgery, DBS), sham 12, surgery morphine) control physiological saline). The electrode was stereotaxically implanted core unilateral NAc...
Highly soluble cocrystals can be used to improve bioavailability of a poorly drug, through generating supersaturation, when absorption is limited by drug dissolution. Dihydromyricetin (DMY) biopharmaceutics classification system (BCS) IV exhibiting dissolution absorption. Two novel (±)DMY with caffeine and urea were prepared, their physicochemical properties evaluated for suitability in formulation development. Although having much higher solubility than (±)DMY, both undergo rapid...
The gastrointestinal (GI) stability of three flavonoids, dihydromyricetin (DMY), myricetin (MYR), and myricitrin (MYT), was examined in simulated physiological fluids. Several factors that may influence the degradation rate theses flavonoids were evaluated, including pH presence pepsin pancreatin enzymes. We found GI followed order MYT > DMY MYR. These stable gastric fluids buffer solutions (pH 1.2), but encountered a pseudo-first-order kinetic intestinal 6.8). conclude it is pH, rather than...
Dual stimuli-responsive unimolecular micelles from “Y”-shape armed amphiphilic star-like copolymer are designed for controlled drug delivery.
Abstract The epithelial–mesenchymal transition (EMT) enhances cellular invasiveness and confers tumor cells with cancer stem cell–like characteristics, through transcriptional translational mechanisms. mechanisms maintaining repression of EMT invasion are poorly understood. Herein, the cell fate determination factor Dachshund (DACH1), suppressed via cytoplasmic induction Snail by inactivating Y box–binding protein (YB-1). In nucleus, DACH1 antagonized YB-1–mediated oncogenic modules...
The relationship between crystal structure and mechanical properties is commonly studied by identifying slip planes through inspecting structures visually, with a focus on the hydrogen bonding interactions. While useful, visualization method lacks quantitative insight, identification of subjective. Sometimes, plasticity predicted from does not match experimental powder tabletability as observed in three polymorphic systems, 6-chloro-2,4-dinitroaniline, indomethacin, febuxostat. Here, we...
Understanding of the structure–mechanical properties relationship in organic crystals can potentially facilitate design with desired mechanical through crystal engineering. To understand and predict properties, including tableting behavior, a number computational methods have been developed to analyze structure. These include visualization, attachment energy calculation, topological analysis, framework, elasticity tensor calculation. However, different often lead conflicting predictions....
Berberine is a drug with an intense bitter taste. The high aqueous solubility of its chloride salt, which commonly used in commercial products berberine, worsens the challenge taste masking. We have approached this delivery by forming salts sweeteners acesulfame and saccharine, through anion exchange reaction. In addition to intrinsic sweetness two counterions, both also exhibit reduced solubility, further alleviates problem limiting dissolution berberine. Moreover, good tableting...
Clear understanding of the relationships among crystal structure, mechanical properties, and tableting performance is enormous importance for successful development tablet products. This study was aimed at systematically examining such using four salts diphenhydramine (DPH), a first-generation H-receptor antagonist, i.e., hydrochloride (DPH-HCl), citrate (DPH-Cit), saccharinate (DPH-Sac), acesulfamate (DPH-Acs). The conformation intermolecular interactions DPH as well packing in were...
Diphenhydramine (DPH) has been used with ibuprofen (IBU) or naproxen (NAP) in combined therapies to provide better clinical efficacy as an analgesic and sleep aid. We discovered that DPH can form protic ionic liquids (PILs) IBU NAP, which opens the opportunity for a new delivery mode of these combination drugs. [DPH][IBU] [DPH][NAP] PILs exhibit low ionicity, confirmed by Fourier transform infrared 1H NMR spectroscopy, accompanied diffusivity, high viscosity, poor conductivity. Evaluation...
The aim of this study was to design and evaluate a cocrystal capable releasing highly water soluble drug, isoniazid (INH), over period longer than several hours by forming with curcumin (CUR). 2:1 INH-CUR can not only lower the dissolution rate INH but also exhibit potential therapeutic synergy. A phase-pure obtained rapid solvent removal above threshold evaporation rate. formation an confirmed powder X-ray diffraction construction temperature–composition phase diagram differential scanning...