A5036091047- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Neonatal and fetal brain pathology
- Inhalation and Respiratory Drug Delivery
- Microencapsulation and Drying Processes
- Nanoparticle-Based Drug Delivery
- Crystallography and molecular interactions
- Tracheal and airway disorders
- Protein purification and stability
- Advanced Drug Delivery Systems
- Glycosylation and Glycoproteins Research
- Drug Solubulity and Delivery Systems
- Tumors and Oncological Cases
- Crystallization and Solubility Studies
- Clinical Nutrition and Gastroenterology
- Neonatal and Maternal Infections
- Monoclonal and Polyclonal Antibodies Research
- Infant Nutrition and Health
- Epilepsy research and treatment
- Histiocytic Disorders and Treatments
- Energetic Materials and Combustion
- Congenital Heart Disease Studies
- Advancements in Transdermal Drug Delivery
- Anesthesia and Neurotoxicity Research
- Vascular Malformations and Hemangiomas
WuXi AppTec (China)
2023-2025
Beijing Children’s Hospital
2012-2024
Capital Medical University
2012-2024
University of Hong Kong
2019-2022
National Center for Women and Children’s Health, China CDC
2020
HKU-Pasteur Research Pole
2019
Chinese University of Hong Kong
2017
The in vitro release study is a critical test to assess the safety, efficacy, and quality of nanoparticle-based drug delivery systems, but there no compendial or regulatory standard. variety testing methods makes direct comparison among different systems difficult. We herein proposed novel sample separate (SS) method by combining United States Pharmacopeia (USP) apparatus II (paddle) with well-validated centrifugal ultrafiltration (CU) technique that efficiently separated free from...
The aim of this study was to design and evaluate a cocrystal capable releasing highly water soluble drug, isoniazid (INH), over period longer than several hours by forming with curcumin (CUR). 2:1 INH-CUR can not only lower the dissolution rate INH but also exhibit potential therapeutic synergy. A phase-pure obtained rapid solvent removal above threshold evaporation rate. formation an confirmed powder X-ray diffraction construction temperature–composition phase diagram differential scanning...
Formulating pharmaceutical cocrystals as inhalable dosage forms represents a unique niche in effective management of respiratory infections. Favipiravir, broad-spectrum antiviral drug with potential pharmacological activity against SARS-CoV-2, exhibits low aqueous solubility. An ultra-high oral dose is essential, causing patient compliance. This study reports Quality-by-Design (QbD)-guided development carrier-free dry powder formulation containing 1:1 favipiravir–theophylline (FAV-THP)...
Cocrystallization represents an emerging approach to tackle the issues associated with pharmaceutical product performance and processing, owing its capability of modifying a variety physicochemical properties. In this study, we sought modify crystal form itraconazole (ITZ) suberic acid (SUB) via rapid solvent removal methods, namely rotary evaporation spray drying. A phase pure ITZ-SUB cocrystal, which could not be obtained by traditional cocrystallization was successfully prepared...
Pulmonary delivery of insulin in the form a dry powder is an attractive alternative comparison to conventional subcutaneous delivery. Insulin crystals have potential advantages such as sustained release and higher stability amorphous particles. However, design crystallization processes that can reliably produce suitable size range for pulmonary challenging. A continuous process involving integration tubular crystallizer spray dryer characterized production inhalable insulin. Supersaturation...
Background: Antibiotics are commonly used in the neonatal intensive care unit (NICU). The objective was to observe effect of weekly antibiotic round NICU (WARN) use NICU. Methods: A retrospective observational study performed. Departmental-level diagnosis categories and parameters usage for period 2016-2017 (Phase 1) 2018-2019 2) were collected. WARN started since January 2018. time series forecasting predict quarterly Phase 2, based on data from 1. actual each quarter 2 compared with...
We herein report the successful synthesis of first two dexamethasone cocrystals from mechanochemistry.
To investigate the clinical characteristics of children with early-onset necrotizing enterocolitis (NEC) undergoing enterostomy and analyze risk factors for postoperative complications.
The neonatal and infantile period is the age group with highest incidence of epilepsy, in which gene variants sodium potassium channels are an important etiology, so channel blocker class antiseizure medications may be effective treatment early onset epilepsy. This study aimed to summarize efficacy tolerability oxcarbazepine (OXC) focal epilepsy neonates infants under 3 months age.A retrospective analysis children within treated OXC a tertiary pediatric center China was conducted. efficacy,...
Objective To investigate the incidence and risk factors in retinopathy of prematurity (ROP) at matched gestational age.Methods Data collected by medical records neonates from November 2007 to December 2010 our neonatal database were analyzed.Patients'information was recorded birth discharge NICU.Data included age after (hours),gestational age,body weight birth,treatment,and maternal demographics.The statistical study carried out SPSS version 13.0 software.Mann - Whitney U test used for...
Objective To analyze the clinical and molecular features of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infection in neonates to investigate their antibiotic resistance profiles. Methods A total 35 invasive CA-MRSA strains were collected from six hospitals 2014. Multilocus sequence typing (MLST), staphylococcal cassette chromosome mec (SCCmec) spa used these isolated strains. In vitro susceptibilities those 15 antibiotics analyzed by using agar dilution...
Objective To investigate the cardiac structure and hypertrophic cardiomyopathy of infant diabetic mother(IDM), to analyze outcome in IDM. Methods Totally 23 cases IDM admitted NICU from Feb.2012 Jan.2013 were selected as observation group, randomly same period with gestational age mother baby control group.The interventricular septum thickness, left ventricular posterior wall aortic valve internal diameter, right ejection fraction detected compared between 2 groups.And...
Objective To discuss the relationship between clinical pathogenesis and progression in neonatal pulmonary hypertension different stages. Methods Total 169 cases of were admitted our NICU from June 2006 to May 2012, all involved this retrospective study. They divided into two groups chronological order: early group 79 (from 2009) late 90 2009 2012). The data records include gender, gestational age, protopathy, echocardiography examination results. Furthermore, cause development...
Objective To analyze of the risk factors for persistent pulmonary hypertension newborn(PPHN) after resuscitation in neonatal asphyxia. Methods Total 92 cases PPHN asphyxia were admitted NICU, Beijing Children's Hospital Affiliated to Capital Medical University from Jan.2009 Dec. 2013 as group. According patients condition, case-control study method randomly selected without same period control group.Except other serious complications with PPHN, such respi-ratory distress syndrome,...