A5058272535- Cancer-related Molecular Pathways
- Chronic Lymphocytic Leukemia Research
- Telomeres, Telomerase, and Senescence
- Retinoids in leukemia and cellular processes
- Lymphoma Diagnosis and Treatment
- Advanced biosensing and bioanalysis techniques
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
- Acute Myeloid Leukemia Research
- interferon and immune responses
- 14-3-3 protein interactions
- RNA Interference and Gene Delivery
- Microtubule and mitosis dynamics
- DNA Repair Mechanisms
- Advanced Breast Cancer Therapies
- CAR-T cell therapy research
- Neurology and Historical Studies
- Antioxidant Activity and Oxidative Stress
- Ethics and bioethics in healthcare
- MicroRNA in disease regulation
- PI3K/AKT/mTOR signaling in cancer
- Ethics in medical practice
- Biosensors and Analytical Detection
- Genetic and Kidney Cyst Diseases
- Chronic Myeloid Leukemia Treatments
University of Leicester
2016-2025
Universitat Oberta de Catalunya
2020-2024
Josep Carreras Leukaemia Research Institute
2023-2024
Laboratory of Molecular Genetics
2020
NIHR Leicester Biomedical Research Centre
2016
Cancer Research UK
2016
Wellcome Library
2015
Icahn School of Medicine at Mount Sinai
2002-2006
Universitat de Barcelona
1997
Abstract Cellular senescence is a terminal differentiation state that has been proposed to have role in both tumour suppression and ageing. This view supported by the fact accumulation of senescent cells can be observed response oncogenic stress as well result normal organismal Thus, identifying vivo vitro an important diagnostic therapeutic potential. The molecular pathways involved triggering and/or maintaining phenotype are not fully understood. As consequence, markers currently utilized...
The p53 tumor suppressor gene can induce either apoptosis or a permanent growth arrest (also termed senescence) phenotype in response to cellular stresses. We show that the increase intracellular reactive oxygen species (ROS) associated with magnitude of protein expression correlated induction senescence both normal and cancer cells. ROS inhibitors ameliorated p53-dependent cell fates, implicating accumulation as an effector each case. absence Bax PUMA strongly inhibited p53-induced...
Tumor suppressor p53 is activated by several stimuli, including DNA damage and oncogenic stress. Previous studies (Takaoka, A., S. Hayakawa, H. Yanai, D. Stoiber, Negishi, Kikuchi, Sasaki, K. Imai, T. Shibue, Honda, Taniguchi. 2003. Nature. 424:516–523) have shown that also induced in response to viral infections as a downstream transcriptional target of type I interferon (IFN) signaling. Moreover, many viruses, SV40, human papillomavirus, Kaposi's sarcoma herpesvirus, adenoviruses, even RNA...
Abstract Heparin-binding epidermal growth factor-like factor (HB-EGF) has been shown to stimulate the of a variety cells in an autocrine or paracrine manner. Although HB-EGF is widely expressed tumors compared with normal tissue, its contribution tumorigenicity unknown. can be produced as membrane-anchored form (pro-HB-EGF) and later processed soluble (s-HB-EGF), although significant amount pro-HB-EGF remains uncleaved on cell surface. To understand roles two forms promoting tumor growth, we...
Nanoparticles (MIPs) specifically detect and target senescent cells by binding to a surface protein, showing also specificity<italic>in vivo</italic>.
Abstract A wide range of diseases have been shown to be influenced by the accumulation senescent cells, from fibrosis diabetes, cancer, Alzheimer’s and other age-related pathologies. Consistent with this, clearance cells can prolong healthspan lifespan in vivo models. This provided a rationale for developing new class drugs, called senolytics, designed selectively eliminate human tissues. The senolytics tested so far lack specificity significant off-target effects, suggesting that targeted...
Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenetic predominantly caused by alteration or dysregulation of PKD1 gene, which encodes polycystin-1 (PC1). The characterized progressive expansion bilateral fluid-filled renal cysts that ultimately lead to failure. Individual cysts, even within patients with germline mutations, are genetically heterogeneous, displaying diverse chromosomal abnormalities. To date, molecular mechanisms responsible for this genetic...
p53 is a tumor suppressor that prevents the emergence of transformed cells by inducing apoptosis or senescence, among other responses. Its functions are regulated tightly posttranslational modifications. Here we show Bruton's tyrosine kinase (BTK) novel modulator p53. We found BTK induced in response to DNA damage and activation. induction leads phosphorylation, which constitutes positive feedback loop increases protein levels enhances transactivation its target genes stress. Inhibiting...
// David S. Guttery 1, * , Kevin Blighe Konstantinos Polymeros 2, 3 R. Paul Symonds 1 Salvador Macip and Esther L. Moss 2 Leicester Cancer Research Centre, University of Leicester, Robert Kilpatrick Building, Royal Infirmary, UK Department Gynaecological Oncology, Hospitals NHS Trust, General Hospital, Mechanisms Ageing Lab, Molecular Cell Biology, These authors have contributed equally to this work Correspondence to: Moss, email: em321@leicester.ac.uk Keywords: endometrial cancer;...
Proteomic mapping of cell surfaces is an invaluable tool for drug development and clinical diagnostics. This work describes a new ‘snapshot imprinting’ method designed to obtain proteomic maps surfaces, with the aim identifying surface markers epitopes diagnostic therapeutic applications. The analysis two cancer lines, HN5 MDA-MB-468, described herein as proof concept, along selective targeting three identified epidermal growth factor receptor using molecularly imprinted polymer...
The accumulation of senescent cells has an important role in the phenotypical changes observed ageing and many age-related pathologies. Thus, strategies designed to prevent these effects, collectively known as senotherapies, have a strong clinical potential. Senolytics are type senotherapy aimed at specifically eliminating from tissues. Several small molecule compounds with senolytic properties already been identified, but their specificity range action variable. Because this, potential...
Mouse Double Minute 2 (MDM2) is a key negative regulator of the tumour suppressor protein p53. MDM2 overexpression occurs in many types cancer and results suppression wild type The 14-3-3 family adaptor proteins are known to bind 14-3-3σ isoform controls cellular localisation stability inhibit its activity. Therefore, small molecule stabilisation 14-3-3σ/MDM2 protein-protein interaction (PPI) potential therapeutic strategy for treatment cancer. Here, we provide detailed biophysical...
The indexed individual, from now on termed M116, was the world's oldest verified living person January 17th 2023 until her passing August 19th 2024, reaching age of 117 years and 168 days (https://www.supercentenarian.com/records.html). She a Caucasian woman born March 4th 1907 in San Francisco, USA, Spanish parents settled Spain since she 8. Although centenarians are becoming more common demographics human populations, so-called supercentenarians (over 110 old) still rarity. In Catalonia,...
Background: This study aimed to evaluate the efficacy of a theatre-based intervention for patients with Parkinson's disease (PD). To this end, we assigned participants two types intervention: a) theatre-based, which included both active and passive participation activities (Teatre Lliure, Barcelona, Spain), b) cognitive stimulation (memory attention) at home (Barcelona, Spain).Method: Before after intervention, were assessed on cognition (memory, language, executive functions), mood...
The BCL-2-specific inhibitor, ABT-199 (venetoclax) has exhibited remarkable clinical activity in nearly all cases of chronic lymphocytic leukemia. In contrast, responses are usually much less diffuse large B-cell lymphoma (DLBCL), despite high level expression BCL-2 over 40% cases, indicating that co-expression related anti-apoptotic family proteins may limit the ABT-199. We have investigated roles DLBCL cells using a panel specific homology 3 (BH3)-mimetics and identified subgroups these...
Introduction: Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal lung disease with poor prognosis and increasing incidence. Pirfenidone nintedanib are the only approved treatments for IPF but have limited efficacy their mechanisms of action poorly understood. Here we examined effects pirfenidone in human model fibrogenesis, compared these putative anti-fibrotic compounds Lipoxin A4 (LXA4), senicapoc, KCa3.1 ion channel blocker. Methods: Early was induced cultured parenchyma using...