Krystle Perez

ORCID: 0000-0001-5456-6059
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About
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Research Areas
  • Neonatal Respiratory Health Research
  • Infant Development and Preterm Care
  • Infant Nutrition and Health
  • Global Maternal and Child Health
  • Child Nutrition and Water Access
  • Neonatal and fetal brain pathology
  • Ethics in Clinical Research
  • Ethics and Legal Issues in Pediatric Healthcare
  • Congenital Diaphragmatic Hernia Studies
  • Pediatric Pain Management Techniques
  • Clinical Nutrition and Gastroenterology
  • Congenital Heart Disease Studies
  • Global Public Health Policies and Epidemiology
  • Insect-Plant Interactions and Control
  • Childhood Cancer Survivors' Quality of Life
  • Child and Adolescent Health
  • Health and Conflict Studies
  • Breastfeeding Practices and Influences
  • Neonatal and Maternal Infections
  • Pulmonary Hypertension Research and Treatments
  • Ethics in medical practice
  • Oral microbiology and periodontitis research
  • Global Health and Surgery
  • Health disparities and outcomes
  • Dental Health and Care Utilization

University of Washington
2018-2025

University of Guelph
2024-2025

Seattle Children's Hospital
2020-2024

American Institute of Aeronautics and Astronautics
2020

University of North Carolina at Chapel Hill
2015

Manchester University NHS Foundation Trust
2012

Newham University Hospital
2012

Queen Elizabeth Hospital
2010

<h3>Importance</h3> Extremely preterm (EP) infants frequently receive opioids and/or benzodiazepines, but these drugs' association with neurodevelopmental outcomes is poorly understood. <h3>Objectives</h3> To describe the use of and benzodiazepines in EP during neonatal intensive care unit (NICU) hospitalization to explore at 2 years' corrected age. <h3>Design, Setting, Participants</h3> This cohort study was a secondary analysis data from Preterm Erythropoietin Neuroprotection (PENUT)...

10.1001/jamanetworkopen.2021.15998 article EN cc-by-nc-nd JAMA Network Open 2021-07-07

<h3>Importance</h3> It remains poorly understood how parents decide whether to enroll a child in neonatal clinical trial. This is particularly true for from racial or ethnic minority populations. Understanding factors associated with enrollment decisions may improve recruitment processes families, increase rates, and decrease disparities research participation. <h3>Objective</h3> To assess differences parental between who enrolled their infant those declined randomized <h3>Design, Setting,...

10.1001/jamanetworkopen.2020.32106 article EN cc-by-nc-nd JAMA Network Open 2021-01-12

<h3>Importance</h3> Practice variability exists in the use of corticosteroids to treat or prevent bronchopulmonary dysplasia extremely preterm infants, but there is limited information on longer-term impacts. <h3>Objective</h3> To describe infants and evaluate association with neurodevelopmental outcomes. <h3>Design, Setting, Participants</h3> This cohort study was a secondary analysis data from Preterm Erythropoietin Neuroprotection (PENUT) randomized clinical trial, conducted at 19...

10.1001/jamanetworkopen.2022.1947 article EN cc-by-nc-nd JAMA Network Open 2022-03-11
Sandra E. Juul Thomas R. Wood Bryan A. Comstock Krystle Perez Semsa Gogcu and 95 more Mihai Puia‐Dumitrescu Sara K. Berkelhamer Patrick J. Heagerty Kaashif A. Ahmad Mariana Baserga Ellen Bendel‐Stenzel Sherry E. Courtney L. Corbin Downey Nancy Fahim Ivan D. Frantz Maureen Gilmore Janine Y. Khan Edmund F. LaGamma Andrea Lampland Jean Lowe Dennis E. Mayock Victor McKay Robin K. Ohls Jorge Perez Raghavendra Rao Tonya Robinson Nishant Srinivasan Rajan Wadhawan Michael Weiss Billy Thomas Nahed O. ElHassan Sarah B. Mulkey Vivek K. Vijayamadhavan Neil Mulrooney Bradley A. Yoder Jordan S. Kase Jennifer Check Erin Osterholm T. Neville George Michael Georgieff Camilia R. Martin Deirdre O’Reilly Raye‐Ann deRegnier Nicolas Porta Catalina Bazacliu Frances J. Northington Raul Chavez‐Valdez Patel Saurabhkumar Magaly Diaz-Barbosa Arturo Serize Jorge Jordán John A. Widness Adam L. Hartman Roberta A. Ballard Michael O’Shea Christopher Nefcy Mark A. Konodi Phuong T. Vu John Feltner Isabella Esposito Stephanie Hauge Samantha Nikirk Amy Silvia Bailey Clopp Debbie Ott Ariana Franco Mora Pamela Hedrick Vicki Flynn Andrea Wyatt Emilie Loy Natalie Sikes Melanie Mason Jana McConnell Tiffany Brown Henry Harrison Denise J. Pearson Tammy Drake Jocelyn H. Wright Debra Walden Annette Guy Jennifer Nason Morgan Talbot Kristen Lee Sarah Penny Terri Boles Melanie Drummond Katy Kohlleppel Charmaine Kathen Brian Kaletka Shania Gonzales Cathy Worwa Molly Fisher Tyler Richter Alexander Ginder Brixen Reich Carrie A. Rau Manndi C. Loertscher Laura Cole Kandace M. McGrath Kimberlee Weaver Lewis

<h3>Importance</h3> Understanding why and how extremely preterm infants die is important for practitioners caring these infants. <h3>Objective</h3> To examine risk factors, causes, timing, circumstances of death in a modern cohort <h3>Design, Setting, Participants</h3> A retrospective review enrolled the Preterm Erythropoietin Neuroprotection Trial between December 13, 2013, September 26, 2016, was conducted. total 941 born 24 0/7 27 6/7 weeks gestation at 19 US sites comprising 30 neonatal...

10.1001/jamanetworkopen.2021.46404 article EN cc-by-nc-nd JAMA Network Open 2022-02-07

Neonatal mortality comprises an increasing proportion of childhood deaths in the developing world. Essential newborn care practices as recommended by WHO may improve neonatal outcomes resource limited settings. Our objective was to pilot a Helping Babies Breathe and Care for Every Baby (HBB ECEB) implementation package using HBB-ECEB training combined with supportive supervision rural Nicaragua. We employed El Ayote Santo Domingo, two municipalities Nicaragua used pre- post- data collection...

10.1186/s12884-018-2003-y article EN cc-by BMC Pregnancy and Childbirth 2018-09-12

The aim of the study was to describe pregnancies in HIV-infected teenagers.A review case notes pregnant teenagers aged 13-19 years from 12 London hospitals carried out for period 2000-2007.There were 67 58 young women, whom one known have acquired HIV vertically. overall mother-to-child transmission (MTCT) rate 1.5% (one 66). There 66 live births. Median ages at diagnosis and conception 17 18 years, respectively. Sixty-three per cent women diagnosed with infection through routine antenatal...

10.1111/j.1468-1293.2010.00878.x article EN HIV Medicine 2010-08-29

Objective Pulmonary hypertension causes substantial morbidity and mortality in infants. Although Food Drug Administration approved to treat pulmonary arterial adults, sildenafil is not for We sought describe exposure associated diagnoses outcomes Study Design Retrospective cohort of neonates discharged from more than 300 neonatal intensive care units 2001 2016. Results Sildenafil was administered 1,336/1,161,808 infants (0.11%; 1.1 per 1,000 infants); 0/35,977 received versus 151/90,544...

10.1055/s-0038-1667378 article EN American Journal of Perinatology 2018-08-06

In very-low-birth-weight (VLBW) infants, the initiation of enteral feedings is frequently delayed and feeding volumes are advanced very slowly.Clinicians often express concerns about gut immaturity consequent increased risk intolerance, spontaneous intestinal perforation (SIP), necrotizing enterocolitis (NEC).Late ultracautious advancement seen all over world, despite known associations with a prolonged need for central venous access sepsis, which one leading causes neonatal...

10.5005/jp-journals-11002-0038 article EN Newborn 2022-10-07

Abstract Preterm birth remains the leading identifiable risk factor for cerebral palsy (CP), a devastating form of motor impairment due to developmental brain injury occurring around time birth. We performed genome wide methylation and whole transcriptome analyses elucidate early pathogenesis CP in extremely low gestational age neonates (ELGANs). evaluated peripheral blood cell specimens collected during randomized trial erythropoietin neuroprotection ELGAN (PENUT Trial, NCT# 01378273). DNA...

10.1038/s41598-021-84214-9 article EN cc-by Scientific Reports 2021-03-05

Neonatal mortality is a significant contributor to under-five-mortality worldwide, comprising approximately 47% of deaths, with the majority occurring in low- and middle-income countries (LMICs).1,2 Prematurity leading cause these deaths.1 The care for preterm neonates remains significantly challenging LMICs despite collaborative efforts from numerous organizations. Furthermore, deaths due prematurity are not further delineated by an exact etiology beyond label "prematurity" as death, which...

10.1016/j.pedneo.2021.01.004 article EN cc-by Pediatrics & Neonatology 2021-01-23

Periodontitis during pregnancy is associated with an increased risk of preterm birth (<37 weeks gestation) or low birthweight (<2500 g) offspring. Beyond periodontal disease, the varies both by previous history and in association social determinants prevalent among vulnerable marginalized populations. This study hypothesized that timing treatment and/or vulnerability measures modified response to dental scaling root planing for periodontitis prevention birth.This aimed determine gravidae a...

10.1016/j.xagr.2023.100167 article EN cc-by-nc-nd AJOG Global Reports 2023-01-26

Infections remain a leading cause of neonatal death, especially among the extremely preterm infants. To evaluate incidence, pathogenesis, and in-hospital outcomes associated with sepsis hospitalized infants born at 24-0/7 to 27-6/7 weeks gestation, we designed post hoc analysis data collected prospectively during Preterm Epo Neuroprotection (PENUT) Trial, NCT #01378273. We analyzed culture positive infection data, as well type duration antibiotic course described their association...

10.3390/jcm12072703 article EN Journal of Clinical Medicine 2023-04-04
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