Jennifer Check
A5031336852- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Birth, Development, and Health
- Family and Disability Support Research
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Child and Adolescent Psychosocial and Emotional Development
- Infant Nutrition and Health
- Epigenetics and DNA Methylation
- Anesthesia and Neurotoxicity Research
- Ovarian function and disorders
- Ethics in Clinical Research
- Autism Spectrum Disorder Research
- Neonatal Health and Biochemistry
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health, Environment, Cognitive Aging
- Infant Health and Development
- Maternal Mental Health During Pregnancy and Postpartum
- Vascular Malformations and Hemangiomas
- Tumors and Oncological Cases
- Prenatal Screening and Diagnostics
- Child Abuse and Trauma
Wake Forest University
2017-2024
Carilion Roanoke Memorial Hospital
2022
Atrium Health Wake Forest Baptist
2016-2022
Northwestern University
2013-2014
University of North Carolina at Chapel Hill
2009-2010
Johnson University
2009
Rutgers, The State University of New Jersey
2008
New Hanover Regional Medical Center
2003
The ability to identify poor outcomes and treatable risk factors among very preterm infants remains challenging; improving early detection intervention targets potentially address developmental behavioral delays is needed. To determine associations between neonatal neurobehavior using the Neonatal Intensive Care Unit (NICU) Network Neurobehavioral Scale (NNNS), medical risk, 2-year outcomes. This multicenter cohort enrolled born at less than 30 weeks' gestation 9 US university-affiliated...
Objective To identify neurobehavioural risks in preterm infants with bronchopulmonary dysplasia (BPD) prior to hospital discharge. Design and patients Longitudinal study of 676 newborns born before 30 weeks gestation. Setting Nine university NICUs affiliated six universities. All were Vermont Oxford Network (VON) participants. Patients interventions Infants enrolled the Neonatal Neurobehavior Outcomes Very Preterm Study from April 2014 June 2016. Prospective medical record reviews, VON...
Using an evidence-based approach, a Vermont Oxford Network focus group whose goal was to reduce brain injury developed and implemented number of potentially better practices. Each center approached implementation the practices differently. Reducing incidence intraventricular hemorrhage periventricular leukomalacia are important for improving long-term outcomes low birth weight infants.Implementation approaches some but not all at various centers discussed. The reviewed include optimal...
Abstract Prior research has identified epigenetic predictors of attention problems in school-aged children but not yet investigated these young children, or at elevated risk due to preterm birth. The current study evaluated epigenome-wide associations between neonatal DNA methylation and age 2 years born very preterm. Participants included 441 from the Neonatal Neurobehavior Outcomes Very Preterm Infants (NOVI) Study, a multi-site infants < 30 weeks gestational age. was measured buccal...
Neonatal care providers from 5 institutions formed a multidisciplinary focus group with the purpose of identifying potentially better practices, implementation which would lead to reduction in incidence intracranial hemorrhage and periventricular leukomalacia very low birth weight infants.Practices were analyzed, 4 benchmark neonatal intensive units identified evaluated, literature was assessed using an evidence-based approach. The work also reviewed by nationally respected expert.Ten...
Liver regeneration after partial hepatectomy (PH) involves several signaling mechanisms including activation of the small GTPases Ras and RhoA in response to mitogens leading DNA synthesis cell proliferation. Peroxisome proliferator-activated receptor-alpha (PPARalpha) regulates expression key enzymes isoprenoid synthesis, which are events for membrane association RhoA. Thus role PPARalpha proliferation PH was tested. After PH, an increase binding observed wild-type mice, correlating with...
Medically complex patients in neonatal intensive care units (NICUs) typically require long hospitalisations and from multiple subspecialists. Scheduled multidisciplinary discussions could improve collaboration continuity of thereby patient outcomes. The specific aims the project were to decrease average length hospitalisation by at least 1 day parent satisfaction ratings on a standard questionnaire end our project's first year, maintain stable (or decreased) cause-related (30-day)...
Importance Emotional and behavioral dysregulation during early childhood are associated with severe psychiatric, behavioral, cognitive disorders through adulthood. Identifying the earliest antecedents of persisting emotional can inform risk detection practices targeted interventions to promote adaptive developmental trajectories among at-risk children. Objective To characterize children’s regulation examine factors across childhood. Design, Setting, Participants This cohort study examined...
<h3>Importance</h3> Understanding why and how extremely preterm infants die is important for practitioners caring these infants. <h3>Objective</h3> To examine risk factors, causes, timing, circumstances of death in a modern cohort <h3>Design, Setting, Participants</h3> A retrospective review enrolled the Preterm Erythropoietin Neuroprotection Trial between December 13, 2013, September 26, 2016, was conducted. total 941 born 24 0/7 27 6/7 weeks gestation at 19 US sites comprising 30 neonatal...
A challenge in implementing population-based DNA screening is providing sufficient information, that is, understandable and acceptable, supports informed decision making. Early Check an expanded newborn study offered to mothers/guardians whose infants have standard North Carolina. We developed electronic education consent meet the objectives of feasibility, acceptability, trustworthiness, supporting decisions. used two methods evaluate among mothers participating who received normal results:...
Prenatal risk factors are related to poor health and developmental outcomes for infants, potentially via epigenetic mechanisms. We tested associations between person-centered prenatal profiles, cumulative models, epigenome-wide DNA methylation (DNAm) in very preterm neonates. studied 542 infants from a multi-center study of born < 30 weeks postmenstrual age. assessed 24 maternal report medical record review. Latent class analysis was used define profiles. DNAm quantified neonatal buccal...
Propranolol is used to treat problematic infantile hemangiomas (IHs), but its safety in infants <5 weeks corrected age has not been established. The objective of this study was assess the and efficacy propranolol for treatment IH age, or 45 gestational (CGA).We performed a single institution, retrospective review patients treated with prior 6 months between 2017 2021. Patient characteristics, location hemangioma(s), weight at initiation treatment, dosing information, side effects, response,...
Cranial ultrasound (CUS) findings are routinely used to identify preterm infants at risk for impaired neurodevelopment, and neurobehavioral examinations provide information about early brain function. The associations of abnormal on late CUS with neurobehavior neonatal intensive care unit (NICU) discharge have not been reported. To examine the between infant NICU discharge. This prospective cohort study included enrolled in Neonatal Neurobehavior Outcomes Very Preterm Infants Study April...
Children born less than 30 weeks gestational age (GA) are at high risk for neurodevelopmental delay compared to term peers. Prenatal factors and neonatal epigenetics could help identify preterm children highest poor cognitive outcomes. We aimed understand the associations among cumulative prenatal risk, DNA methylation, child ability 3 years, including whether methylation mediates association between ability. studied 379 neonates (54% male) GA who had measured intensive care unit discharge...