A5041912704- Iron Metabolism and Disorders
- Neonatal Respiratory Health Research
- Hemoglobinopathies and Related Disorders
- Neonatal and fetal brain pathology
- Neonatal Health and Biochemistry
- Infant Development and Preterm Care
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Trace Elements in Health
- Infant Nutrition and Health
- Erythropoietin and Anemia Treatment
- Fetal and Pediatric Neurological Disorders
- Genetics and Neurodevelopmental Disorders
- Erythrocyte Function and Pathophysiology
- Pregnancy and preeclampsia studies
- Autism Spectrum Disorder Research
- Ultrasound in Clinical Applications
- Pharmacological Effects and Toxicity Studies
- Birth, Development, and Health
- Congenital Heart Disease Studies
- Genomics and Rare Diseases
- Tracheal and airway disorders
- Congenital heart defects research
- Child Nutrition and Water Access
Seattle Children's Hospital
2019-2024
University of Washington
2017-2024
To support decision-making in the primary care medical home, this clinical report links preterm birth and perinatal complications to early childhood developmental disability risks. It consolidates extensive contemporary outcome research from 2005 onward into an easy-to-use framework stratifies prematurity NICU experiences by degree of risk for impairments. This informs prioritizes point-of-care screening surveillance strategies pediatricians caring children born preterm, guides additional...
Abstract Background Associations of 2-year neurodevelopmental and behavioral outcomes with growth trajectories preterm infants are unknown. Methods This secondary analysis a cohort examined in-hospital discharge to changes in anthropometric z-scores. Two-year follow-up included Bayley Scales Infant Development (BSID-III) Child Behavior Checklist. Results Among 590 infants, adjusted was not associated any BSID-III subscale. Occipitofrontal circumference (OFC) failure (GF) increased odds...
<h3>Importance</h3> Practice variability exists in the use of corticosteroids to treat or prevent bronchopulmonary dysplasia extremely preterm infants, but there is limited information on longer-term impacts. <h3>Objective</h3> To describe infants and evaluate association with neurodevelopmental outcomes. <h3>Design, Setting, Participants</h3> This cohort study was a secondary analysis data from Preterm Erythropoietin Neuroprotection (PENUT) randomized clinical trial, conducted at 19...
Abstract Monogenic disorders account for a large proportion of population-attributable risk neurodevelopmental disabilities. However, the data necessary to infer causal relationship between given genetic variant and particular disorder is often lacking. Recognizing this scientific roadblock, 13 Intellectual Developmental Disabilities Research Centers (IDDRCs) formed consortium create Brain Gene Registry (BGR), repository pairing clinical with phenotypic from participants variants in putative...
We describe a neonate with severe respiratory failure due to acinar dysplasia found by rapid exome sequencing (rES), have deletion containing the TBX4 gene. rES can affect patient management in intensive care unit and should be considered concert lung biopsy neonates undifferentiated failure.
Despite strong evidence for its utility in clinical management and diagnosis of intracranial hemorrhage (ICH), the use neonatal cranial point-of-care ultrasound (POCUS) has not been standardized intensive care units (NICUs) United States. The primary aim this study was to evaluate feasibility training NICU providers perform POCUS by tracking quality image acquisition following training.
The association of 2-year neurodevelopmental and behavioral outcomes with in-hospital or post-discharge growth failure (GF) using contemporary definitions for preterm infants is unknown.
Background: Iron deficiency during critical windows of brain development leads to irreversible neurodevelopmental delays. To limit this risk, iron supplementation in preterm infants is recommended, however concern persists regarding the risk pro-oxidant injury with supplementation. It unclear whether extremely low gestational age newborns (ELGANs) are able regulate their status through hepcidin, primary regulator adults. Objective: Assess role urine hepcidin (Uhep) as a …