Samantha Nikirk
A5074330854- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Drug-Induced Hepatotoxicity and Protection
- Optimism, Hope, and Well-being
- Infant Development and Preterm Care
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Neonatal Health and Biochemistry
- Viral gastroenteritis research and epidemiology
- Pain Mechanisms and Treatments
- Thermoregulation and physiological responses
- Family Caregiving in Mental Illness
- Acute Kidney Injury Research
- Global Health Care Issues
- Heart Rate Variability and Autonomic Control
- Hepatitis C virus research
- Health Systems, Economic Evaluations, Quality of Life
- Pharmacological Effects of Natural Compounds
- Hepatitis Viruses Studies and Epidemiology
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Organ Transplantation Techniques and Outcomes
- Congenital Diaphragmatic Hernia Studies
- COVID-19 and Mental Health
University of Michigan–Ann Arbor
2019-2025
Michigan Medicine
2024
Yahoo (United Kingdom)
2023
University of Washington
2021-2022
Hepatic encephalopathy (HE) is associated with marked increases in morbidity and mortality for patients cirrhosis. We aimed to determine the risk of predictors HE contemporary patients.We prospectively enrolled 294 subjects Child A-B (70% A) cirrhosis portal hypertension without previous from July 2016 August 2018. The primary outcome was development overt (grade >2). assessed predictive power model end-stage liver disease-sodium (MELD-Na) score, Inhibitory Control Test, Sickness Impact...
Background and Aims: Poor patient-reported outcomes (PROs) are common in cirrhosis, including poor sleep health-related quality of life (HRQOL). HE is a major driver PROs. Many clinicians initiate lactulose therapy to address PRO-triggered therapy, however, has not been studied till date. Methods: We conducted 28-day randomized trial crystalline (20 g BID) compared with no HE-directed 52 patients portal hypertension, prior HE, high Work Productivity Activity Impairment scores (0–10)...
Introduction: Falls are a major threat to the well-being of patients with cirrhosis. We performing clinical trial determine whether lactulose, TeleTai-Chi, or their combination will reduce falls in HE and improve health-related quality life (HRQOL) among Methods Analysis: Patients cirrhosis portal hypertension without be enrolled 3 US states followed participants for 24 weeks. In stage 1 (12 wk), randomized receive either lactulose therapy enhanced usual care. 2 TeleTai-Chi The primary...
Caregivers for patients with cirrhosis face immense physical and psychological strain that negatively impact quality of life ability to care oneself. The aim is explore the caregiver experience cirrhosis, identify prominent stressors, understand multidimensional contributors burden, help tailor effective interventions. caregivers 25 decompensated underwent semistructured in-person interviews completed written exercises targeting emotional disclosure or resilience training were analyzed...
<h3>Importance</h3> Understanding why and how extremely preterm infants die is important for practitioners caring these infants. <h3>Objective</h3> To examine risk factors, causes, timing, circumstances of death in a modern cohort <h3>Design, Setting, Participants</h3> A retrospective review enrolled the Preterm Erythropoietin Neuroprotection Trial between December 13, 2013, September 26, 2016, was conducted. total 941 born 24 0/7 27 6/7 weeks gestation at 19 US sites comprising 30 neonatal...
Abstract Background Muscle cramps are common among persons with cirrhosis and associated poor health‐related quality of life (HRQOL). Treatment options limited. We compared stretching or meditation in a randomized‐controlled trial (RCT). Patients enrolled 98 patients history >4 muscle the prior month from 7/22–7/23. randomized 1:1 to versus for 35 days. Our primary outcome was change cramp severity measured by visual analogue scale (VAS‐cramps, scaled 0–10). Secondary outcomes included...
Cost-effectiveness analysis depends on generalizable health-state utilities. Unfortunately, the available utilities for cirrhosis are dated, may not reflect contemporary patients, and do capture impact of symptoms. We aimed to determine cirrhosis, using both standard gamble (SG) visual analog scale (VAS). prospectively enrolled 305 patients. Disease severity (Child-Pugh [Child] class, Model End-Stage Liver with sodium [MELD-Na] scores), symptom burden (sleep quality, cramps, falls,...
Cognitive dysfunction is a major driver of care complexity, poor patient-reported outcomes, and frailty for people with cirrhosis. The performance clinical associations the animal naming test (ANT) in general population are unknown. We evaluated ANT representative sample older Americans without chronic liver disease (CLD).We analyzed 6,661 subjects enrolled 2010-2016 Health Retirement Survey, cohort >30,000 US adults. Average age participants was 75 years. 3 subject subgroups: (i) CLD, (ii)...
Abstract Background and Aims Multiple medications are associated with an increased risk of incident hepatic encephalopathy. Despite this known risk, such as opioids, benzodiazepines, gabapentin/pregabalin, and/or proton pump inhibitors increasingly prescribed to persons cirrhosis. Deprescribing is a promising intervention reduce the burden Given that deprescribing has not been trialed in cirrhosis, we evaluated barriers facilitators safe successful Methods We conducted, transcribed, analyzed...
Ascites is a costly, morbid complication of cirrhosis. Although low-sodium diet central to the clinical management ascites, its efficacy limited by poor adherence. We aimed determine feasibility and impact medically tailored meals (MTM) intervention.