A5005775867- Child Nutrition and Water Access
- Child Nutrition and Feeding Issues
- Food Security and Health in Diverse Populations
- Infant Nutrition and Health
- Infant Development and Preterm Care
- Neonatal Respiratory Health Research
- Global Maternal and Child Health
- Birth, Development, and Health
- Maternal and Neonatal Healthcare
- COVID-19 Impact on Reproduction
- Breastfeeding Practices and Influences
- Nutrition and Health in Aging
- Neonatal and Maternal Infections
- Poverty, Education, and Child Welfare
- Gestational Diabetes Research and Management
- Nutritional Studies and Diet
- Diet and metabolism studies
- Consumer Attitudes and Food Labeling
- Congenital Anomalies and Fetal Surgery
- Pregnancy and preeclampsia studies
- Clinical Nutrition and Gastroenterology
- Viral Infections and Vectors
- Assisted Reproductive Technology and Twin Pregnancy
- Healthcare Systems and Challenges
- Mosquito-borne diseases and control
University of Washington
2022-2025
Seattle Children's Hospital
2023-2024
Washington University in St. Louis
2018-2022
St. Louis Children's Hospital
2018
Abstract Background Associations of 2-year neurodevelopmental and behavioral outcomes with growth trajectories preterm infants are unknown. Methods This secondary analysis a cohort examined in-hospital discharge to changes in anthropometric z-scores. Two-year follow-up included Bayley Scales Infant Development (BSID-III) Child Behavior Checklist. Results Among 590 infants, adjusted was not associated any BSID-III subscale. Occipitofrontal circumference (OFC) failure (GF) increased odds...
Objective We hypothesised that an alternative RUTF (ready-to-use therapeutic food) made with oats (oat-RUTF) would be non-inferior to standard (s-RUTF). Design This was a randomised, triple-blind, controlled, clinical non-inferiority trial comparing oat-RUTF s-RUTF in rural Sierra Leone. Children aged 6–59 months severe acute malnutrition (SAM) were randomised or s-RUTF. composed of milk powder, sugar, peanut paste and vegetable oil, hydrogenated oil additive. Oat-RUTF contained no...
Background Innovations for undernourished pregnant women that improve newborn survival and anthropometry are needed to achieve the Sustainable Development Goals 1 3. This study tested hypothesis a combination of nutritious supplementary food several proven chemotherapeutic interventions control common infections would increase weight length in women. Methods findings was prospective, randomized, controlled clinical effectiveness trial ready-to-use (RUSF) plus anti-infective therapies...
There is a lack of consensus on what the most appropriate treatment moderate acute malnutrition (MAM). We aimed to determine if provision ready-to-use-therapeutic food (RUTF) and antibiotics "high-risk" MAM (HR-MAM) children in addition nutritional counseling would result higher recovery less deterioration than nutrition alone. At 11 intervention clinics, HR-MAM were given RUTF amoxicillin along with standard counseling, for 2-12 wk. All others received 6 wk was defined as midupper arm...
Objectives To investigate the feasibility of eye-tracking-based testing speed visual orienting in malnourished young children at rural clinics Sierra Leone. Design Prospective dual cohort study nested a cluster-randomised trial. Setting 8 sites participating trial supplementary feeding for moderate acute malnutrition (MAM). Participants For MAM cohort, all infants aged 7–11 months eight were enrolled, 138 altogether. controls, convenience sample non-malnourished same eligible, 60 A 30 adults...
The negative synergy between poor nutritional status and infectious diseases is doubly detrimental in pregnancy. In Sierra Leone, maternal malnutrition amongst the highest world, while mortality high at 1320/100,000 live births stunting under-five 37.9%, ranked 110/132 worldwide. Maternal has been associated with preterm birth, small-for-gestational age infants, outcomes. Infants born prematurely or experience higher are risk for decreased cognitive performance. Nutritional interventions...
Malnutrition in children is most often attributed to inadequate nutrient intake. Utilizing data from 2 prospective, randomized controlled trials of complimentary feeding with supplemental legumes (n = 693, ages 6-24 months) Malawian villages, Masenjere, and Limera, we document a high rate 70/693 (10.1%) acute malnutrition (AM). Risks for AM this setting, as determined by Cox regression analysis, include study village (hazard ratio [HR] 3.0), prior (HR 4.12), stunting 2.87), marker food...
Ready-to-use therapeutic food (RUTF) given at 175 kcal/kg per day throughout severe acute malnutrition (SAM) treatment is recommended. Some programs have diverged from this paradigm in 2 ways: reducing the supplemental dose to 75 when midupper arm circumference (MUAC) >11.4 cm or simplifying a fixed-dose regimen.
Abstract Undernutrition during pregnancy in adolescence confers a high risk of maternal morbidity and adverse birth outcomes, particularly low‐resource settings. In secondary analysis, we hypothesized that younger undernourished pregnant adolescents (<18 years) would benefit more than adults (>20 from the intervention supplementary food anti‐infective treatments. The original trial Sierra Leone enrolled 236 years), 454 older (aged 18–19 741 (≥20 all with mid‐upper arm circumference ≤23...
Breastfeeding provides optimal infant nutrition; however, <50% of infants are exclusively breastfed (EBF) for 6 months. We aimed to describe breastfeeding practices and their effects on growth mortality among a high-risk mother-infant cohort in rural Sierra Leone. This was secondary analysis data from randomized nutrition intervention trial undernourished pregnant women. The study’s primary outcomes were weight length gains at weeks age. included 1270 singleton the analysis, with 1092...
Appropriate nutrition during pregnancy and the post-partum period is vital to both parent their offspring. Both under- over-nourished status may have important microbial implications on parental infant gut microbiomes. Alterations microbiome can for a person’s risk of obesity metabolic diseases. In this review, we examine alterations in gut, vaginal, placental, milk microbiomes context pre-pregnancy BMI, gestational weight gain, body composition, diabetes, diet. We also investigate how be...
The association of 2-year neurodevelopmental and behavioral outcomes with in-hospital or post-discharge growth failure (GF) using contemporary definitions for preterm infants is unknown.
Objective This study aimed to examine fetal and neonatal inflammatory neurologic complications associated with maternal coronavirus disease 2019 (COVID-19) infection. Study Design Case-series using a convenience sample of neonates cared for in large referral-based children's hospital intensive care unit between September 2021 May 2022. Results We identified seven exposure severe acute respiratory syndrome related 2 (SARS-CoV-2) presentation consistent complications. All had some degree...
Abstract Objective The aim of this study is to determine the association intrapartum risk factors and infant clinical indicators using National Institute for Health Care Excellence (NICE) criteria with culture-positive early-onset neonatal sepsis (EONS) from a rural secondary healthcare facility where prophylactic antibiotics are routinely administered high-risk mothers. Methods A single-center prospective observational was conducted between July 2017 September 2018. All intramural neonates...