A5036387079- Neonatal Respiratory Health Research
- Pharmaceutical studies and practices
- Congenital Heart Disease Studies
- Heart Failure Treatment and Management
- Mechanical Circulatory Support Devices
- Acute Kidney Injury Research
- Antibiotics Pharmacokinetics and Efficacy
- Pulmonary Hypertension Research and Treatments
- Renal function and acid-base balance
- Language Development and Disorders
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Phonetics and Phonology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Reading and Literacy Development
- Cardiac Arrhythmias and Treatments
- Simulation-Based Education in Healthcare
- Child Nutrition and Feeding Issues
- Cardiac electrophysiology and arrhythmias
- Blood disorders and treatments
- Hemodynamic Monitoring and Therapy
- Pharmacological Effects and Toxicity Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Infant Development and Preterm Care
- Sepsis Diagnosis and Treatment
Duke University
2018-2025
Clinical Research Institute
2019-2025
Duke University Hospital
2018-2025
University of North Carolina at Chapel Hill
2024-2025
Duke Medical Center
2018-2024
University of Virginia
2021
Duke Children's Hospital & Health Center
2019
Pediatrics and Genetics
2019
University of Phoenix
2015
Lancaster General Hospital
1994-2014
Abstract Objective To investigate the effects of tocilizumab (TCZ) added to a stable dosage methotrexate (MTX) on biochemical markers bone and cartilage metabolism in patients multicenter double‐blind, placebo‐controlled OPTION (Tocilizumab Pivotal Trial Methotrexate Inadequate Responders) study who have moderate‐to‐severe rheumatoid arthritis (RA) an inadequate response MTX. Methods Included this were 416 623 with active RA enrolled study. Patients randomized receive TCZ (4 mg/kg or 8...
Abstract The mainstay of treatment for infants with hypoxic‐ischemic encephalopathy (HIE) is cooling. Caffeine may be an important adjunct to cooling and provide neuroprotection via its anti‐inflammatory anti‐oxidative properties. This study aimed characterize caffeine pharmacokinetics in term HIE receiving In this phase 1, dose‐escalating study, enrolled received IV 20 mg/kg followed by up two daily doses 5 or 10 mg/kg. A population pharmacokinetic analysis was performed using NONMEM...
Abstract Background: Cardiac surgery-associated acute kidney injury (CS-AKI) and fluid overload (FO) are common among neonates who undergo cardiopulmonary bypass, increase mortality risk. Current diagnostic criteria may delay diagnosis. Thus, there is a need to identify urine biomarkers that permit earlier more accurate Methods: This single-centre ancillary prospective cohort study describes age- disease-specific ranges of 14 at perioperative time points explores associations with CS-AKI FO....
Abstract Pantoprazole is a proton pump inhibitor indicated for the treatment of gastroesophageal reflux disease, condition that disproportionately affects children with obesity. Appropriately dosing pantoprazole in obesity requires understanding body size metric best guides dosing, but pharmacokinetic (PK) trials using traditional techniques are limited by need larger sample sizes and frequent blood sampling. Physiologically‐based PK (PBPK) models an attractive alternative can account...
On-body sensor-based human activity recognition (HAR) lags behind other fields because it lacks large-scale, labeled datasets; this shortfall impedes progress in developing robust and generalized predictive models. To facilitate researchers collecting more extensive datasets quickly efficiently we developed SenseCollect. We did a survey interviewed student area to identify what barriers are making difficult collect on-body HAR data from subjects. Every interviewee identified collection as...
Abstract —Plasma homocysteine concentrations are elevated in UK Indian Asians and may contribute to twice as many coronary heart disease (CHD) deaths this group compared with European whites. The mechanisms underlying among not well understood. In study, we have investigated the extent which methylenetetrahydrofolate reductase (MTHFR) 677 C → T mutation accounts for plasma increased CHD risk We 454 male cases (with myocardial infarction or angiographically proven CHD: 224 Asians, 230 whites)...
A mother and son are reported with chronic dacrocystitis, cup shaped ears, hearing loss, abnormal teeth, poor formation of saliva tears. They similar to previously cases lacrimo-auriculo-dento-digital (LADD) syndrome. The variability expression this autosomal dominant syndrome is discussed, it suggested that tear be added the phenotype.
In Brief To ensure succession planning within the ranks of nurse managers meet current and projected nursing management needs organizational goals, we developed implemented a manager residency program at our hospital. By identifying, supporting, mentoring clinical experts who express desire display an aptitude for leadership, are graduating individuals can transition to position with greater ease competence. With increasingly complex dynamic healthcare landscape, it is no longer prudent...
<b>Background:</b> Infants undergoing cardiac surgery with cardiopulmonary bypass (CPB) frequently receive intra-operative methylprednisolone (MP) to suppress CPB-related inflammation; however, the optimal dosing strategy and efficacy of MP remain unclear. <b>Methods:</b> We retrospectively analyzed all infants under 90 days-old who received for CPB from 2014–2017 at our institution. combined real-world data electronic health record (EHR) two previously developed population...
Objective Pulmonary hypertension causes substantial morbidity and mortality in infants. Although Food Drug Administration approved to treat pulmonary arterial adults, sildenafil is not for We sought describe exposure associated diagnoses outcomes Study Design Retrospective cohort of neonates discharged from more than 300 neonatal intensive care units 2001 2016. Results Sildenafil was administered 1,336/1,161,808 infants (0.11%; 1.1 per 1,000 infants); 0/35,977 received versus 151/90,544...
Abstract Background: Preoperative mechanical ventilation is associated with morbidity and mortality following CHD surgery, but prior studies lack a comprehensive analysis of how preoperative respiratory support mode timing affects outcomes. Methods: We retrospectively collected data on children <18 years age undergoing cardiac surgery at an academic tertiary care medical centre. Using multivariable regression, we examined the association between modes (nasal cannula, high-flow nasal...
Pharmacokinetic models rarely undergo external validation in vulnerable populations such as critically ill infants, thereby limiting the accuracy, efficacy, and safety of model-informed dosing real-world settings. Here, we describe an opportunistic approach using dried blood spots (DBS) to evaluate a population pharmacokinetic model metronidazole preterm infants gestational age (GA) ≤31 weeks from Metronidazole Pharmacokinetics Premature Infants (PTN_METRO, NCT01222585) study. First, used...
Objectives: To determine the pharmacokinetics, pharmacodynamics, and safety of hepatically metabolized endothelin receptor antagonist, ambrisentan in children after Fontan surgery. Design: Prospective, randomized, double-blind, placebo-controlled pharmacokinetic/pharmacodynamics trial. Setting: Single-center, postoperative cardiac ICU. Patients: Children undergoing elective Interventions: Subjects randomized on day number 1 to short-term (3 d) treatment with oral (2.5 mg suspension, daily)...
Objective To analyse the cost, effectiveness and cost of two endometrial thinning agents prior to laser ablation for dysfunctional uterine bleeding: danazol goserelin. Setting A district general hospital. Design retrospective analysis, from perspective health service, based on data an open, randomised, parallel group comparative study 160 pre‐menopausal women with bleeding. Methods Within trial, length operation duration hospital stay was recorded each woman. Resource use due complications...
OBJECTIVES: To examine the association between three perioperative urine biomarker concentrations (urine cystatin C [uCysC], neutrophil gelatinase-associated lipocalin [uNGAL], and kidney injury molecule 1 [uKIM-1]), cardiac surgery-associated acute (CS-AKI) fluid overload (FO) in infants with congenital heart disease undergoing surgery on cardiopulmonary bypass. explore how biomarkers are associated distinct CS-AKI phenotypes based FO status. DESIGN: Ancillary prospective cohort study....