A5057603642- Diversity and Career in Medicine
- Lung Cancer Diagnosis and Treatment
- Innovations in Medical Education
- Surgical Simulation and Training
- Gastric Cancer Management and Outcomes
- Cancer Risks and Factors
- Cancer Diagnosis and Treatment
- Learning Styles and Cognitive Differences
- Evaluation of Teaching Practices
- Hospital Admissions and Outcomes
- Breast Cancer Treatment Studies
- Neonatal Respiratory Health Research
- Immunotherapy and Immune Responses
- Metastasis and carcinoma case studies
- Cancer Research and Treatments
- Sphingolipid Metabolism and Signaling
- Global Cancer Incidence and Screening
- Chemokine receptors and signaling
- Breast Lesions and Carcinomas
- Pancreatic and Hepatic Oncology Research
- Speech and dialogue systems
- Multiple and Secondary Primary Cancers
- Cancer Cells and Metastasis
- Drug Transport and Resistance Mechanisms
- Visual and Cognitive Learning Processes
Carnegie Mellon University
2024
Brookdale University Hospital and Medical Center
2012-2024
University of Pennsylvania
2021
Douglass Hanly Moir Pathology
2020
Southern Illinois University School of Medicine
2018-2019
University of Pennsylvania Health System
2019
Yale University
2016-2017
Louisiana State University Health Sciences Center Shreveport
2010-2016
Virginia Commonwealth University
2009-2014
Memorial Regional Medical Center
2014
p53 promotes apoptosis in response to death stimuli by transactivation of target genes and transcription-independent mechanisms. We recently showed that wild-type rapidly translocates mitochondria multiple cultured cells. Mitochondrial physically interacts with antiapoptotic Bcl proteins, induces Bak oligomerization, permeabilizes mitochondrial membranes, cytochrome c release. Here we characterize the vivo. Mice were subjected γ irradiation or intravenous etoposide administration, followed...
Sphingosine 1-phosphate (S1P), a potent sphingolipid mediator produced by sphingosine kinase isoenzymes (SphK1 and SphK2), regulates diverse cellular processes important for breast cancer progression acting in an autocrine and/or paracrine manner. Here we show that SphK1, but not SphK2, increased S1P export from MCF-7 cells. Whereas both estradiol (E2) epidermal growth factor-activated SphK1 production of S1P, only E2 stimulated rapid release dihydro-S1P E2-induced required estrogen...
Extremely premature infants are at high risk of developing invasive candidiasis; fluconazole prophylaxis is safe and effective for reducing candidiasis in this population but further study needed. We sought to better understand the effect prophylactic on a selection fluconazole-resistant Candida species.We evaluated susceptibility isolates from (<750 g birth weight) enrolled multicentre, randomized, placebo-controlled trial prophylaxis. species were isolated through surveillance cultures...
Abstract Purpose: Prostate cancer is the most common male malignancy and second leading cause of death; therefore, there urgent necessity for noninvasive assays early detection prostate cancer. Obtaining tumor samples surgically problematic because heterogeneous multifocal early-stage tumors are nonpalpable. In contrast, exfoliated cells represent status entire gland better due to general tendency exfoliate into biological fluids. The purpose this study was clarify whether quantitative...
A hemodynamically significant Patent ductus arteriosus (HsPDA) in premature infants is known to be associated with morbidity. Recently brain natriuretic peptides and superior mesenteric artery (SMA)-resistive indices have been used effectively diagnose HsPDA.To assess the sensitivity specificity of N-terminal proBNP (NT-proBNP) predicting an HsPDA diagnosed by clinical echocardiographic criteria including pulsatility index (PI) SMA.All preterm neonates <1500 g were evaluated echocardiograms...
The aim of our study is to evaluate the effectiveness newly implemented general surgery intern boot camp. A 2-day didactic and skills-based camp was before start clinical duties. Participants who did not attend all activities had prior postgraduate training were excluded. survey utilizing a 5-point Likert scale scoring system used assess participants’ confidence perform intern-level tasks after Subgroup analyses performed comparing changes in among graduates from home institution versus...
The molecular basis of sarcoma remains poorly understood. However, recent studies have begun to uncover some the pathways involved in sarcomagenesis. chemokine receptor CXCR4 has been implicated development and found be a prognostic marker for poor clinical outcome. There is growing evidence that overexpression plays significant role metastatic disease, especially directing tumor cells towards preferential sites metastases sarcoma, lung bone. Although further investigation necessary validate...
Abstract Background Node‐positive breast cancer patients are a high‐risk group. However, not all such will succumb to the disease. The molecular basis for this biologic heterogeneity is poorly understood. chemokine receptor CXCR4 marker of metastatic Its prognostic role in node‐positive unknown. We postulate that high overexpression specimens predicts poor outcome. Methods 185 were evaluated. All had standardized treatment and surveillance protocols. levels detected with Western blots....