A5028311760- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Coronary Artery Anomalies
- Cardiac pacing and defibrillation studies
- Cardiovascular Issues in Pregnancy
- Pulmonary Hypertension Research and Treatments
- Congenital Diaphragmatic Hernia Studies
- Aortic Disease and Treatment Approaches
- Ultrasound in Clinical Applications
- Cardiovascular and Diving-Related Complications
- Cardiac Imaging and Diagnostics
- Mechanical Circulatory Support Devices
- Neonatal Respiratory Health Research
- Cardiovascular and exercise physiology
- Tracheal and airway disorders
- Congenital heart defects research
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Syncope and Autonomic Disorders
- Anatomy and Medical Technology
- Cardiovascular Conditions and Treatments
- Cardiovascular Effects of Exercise
- Kawasaki Disease and Coronary Complications
Duke Medical Center
2016-2025
Duke University
2012-2024
Duke Children's Hospital & Health Center
2021-2024
Pediatrics and Genetics
2024
Duke University Hospital
2008-2023
Clinical Research Institute
2023
Children's Hospital of Philadelphia
2011-2013
New England Research (United States)
2010-2013
Durham University
2012-2013
Hospital for Sick Children
2011-2013
Background— Angiotensin-converting enzyme inhibitor therapy improves clinical outcome and ventricular function in adults with heart failure. Infants single-ventricle physiology have poor growth are at risk for abnormalities systolic diastolic function. The ability of angiotensin-converting to preserve improve somatic outcomes these infants is unknown. Methods Results— Pediatric Heart Network conducted a double-blind trial involving 230 randomized receive enalapril (target dose 0.4 mg · kg −1...
AAP : American Academy of Pediatrics AEPC : Association for European Paediatric Cardiology ASE : Society Echocardiography CDH : Congenital diaphragmatic hernia CHD : heart disease EAE : Echocardiography ECMO : Extracorporeal membrane oxygenation EF : Ejection fraction LV : Left ventricular MPI : Myocardial performance index mVCFc : Mean velocity circumferential fiber shortening NICU : Neonatal intensive care unit PA : Pulmonary artery PDA : Patent ductus arteriosus RA : Right atrial RV :...
Cardiac strain and rate are new methods to quantitate fetal cardiac function. Doppler-based techniques regional measurements limited by angle of insonation. Newer feature-tracking algorithms permit independent from two-dimensional datasets. This report describes the novel measurement global strain, rate, velocity using Velocity Vector Imaging (VVI) in a group fetuses with without heart disease.Global segmental longitudinal were performed on right left ventricles 33 normal 15 disease....
Background— Despite medical advances, children with dilated cardiomyopathy (DCM) remain at high risk of death or need for cardiac transplantation. We sought to identify predictors disease progression in pediatric DCM. Methods and Results— The Pediatric Heart Network evaluated chronic DCM patients prospective echocardiographic clinical data collection during an 18-month follow-up. Inclusion criteria were age <22 years duration >2 months. Patients requiring intravenous...
Determine sildenafil exposure and hemodynamic effect in children after Fontan single-ventricle surgery.
Infants with persistent pulmonary hypertension of the newborn (PPHN) have elevated vascular resistance that can lead to right ventricular (RV) failure and death. Clinicians must decide which infants will fail conventional therapy require transfer extra corporeal membrane oxygenation (ECMO) centres, but accurate echocardiographic predictors not been identified. We assessed measurements RV pressure function in predicting progression death or ECMO PPHN. Echocardiograms for ≥35-week gestation a...
In adolescents and adults with tetralogy of Fallot (TOF), right ventricle (RV) electromechanical dyssynchrony (EMD) due to bundle branch block (RBBB) is associated reduced exercise capacity RV dysfunction. While the development RBBB following surgical repair (rTOF) a frequent sequela, it not known whether EMD present in every patient immediately rTOF. The specific timing onset rTOF therefore provides an opportunity assess acute simultaneous acquisition EMD. Transthoracic echocardiography...
Objectives: To determine sildenafil exposure and hemodynamic effect in children after stage II single-ventricle surgery. Design: Prospective, dose escalation trial. Setting: Single-center, pediatric catheterization laboratory. Patients: Twelve poststage surgical palliation undergoing elective cardiac catheterization: median age 1.9 years (range, 0.8, 4.0), weight 11 kg (8, 13), nine females, 10 with a single right ventricle. Interventions: Catheterization echocardiography performed before...
<b>Objective</b> To compare the left ventricular eccentricity index (EI) and tricuspid valve systolic–diastolic (SD) ratio in infants at risk of bronchopulmonary dysplasia (BPD) pulmonary hypertension (PH). <b>Study Design</b> Review echocardiograms performed on born ≤ 28 weeks' postmenstrual age, categorized into following three cohorts: BPD PH (<i>n</i> = 13); only 16); controls 59). EI was measured from a parasternal short axis 2D image. The SD continuous wave Doppler tracing. Groups were...
Abstract Objectives Describe the use of three‐dimensional (3D) patent ductus arteriosus (PDA) modeling to better define ductal anatomy improve preprocedural planning for stent placement. Background Ductal stenting is an alternative surgical shunting in patients with dependent pulmonary blood flow. often complex extreme tortuosity and risk artery isolation, thus increasing procedural risks. Methods CT angiograms were segmented produce 3D PDA models. morphology was characterized attention...