A5016521611- Cancer Immunotherapy and Biomarkers
- Head and Neck Cancer Studies
- Endometriosis Research and Treatment
- Behavioral and Psychological Studies
- Radiopharmaceutical Chemistry and Applications
- Child Nutrition and Feeding Issues
- Reproductive System and Pregnancy
- Medicinal Plant Research
- Orthopaedic implants and arthroplasty
- Autism Spectrum Disorder Research
- Uterine Myomas and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacological Effects and Toxicity Studies
- Diverse Scientific Research Studies
- Colorectal and Anal Carcinomas
- Effects and risks of endocrine disrupting chemicals
- Microplastics and Plastic Pollution
- Blood disorders and treatments
- Environmental Toxicology and Ecotoxicology
- Piperaceae Chemical and Biological Studies
University of Oklahoma Health Sciences Center
2024
Merck & Co., Inc., Rahway, NJ, USA (United States)
2023
University of the Philippines Manila
2019-2022
The Chicago School
2016
Pharmacokinetic models rarely undergo external validation in vulnerable populations such as critically ill infants, thereby limiting the accuracy, efficacy, and safety of model-informed dosing real-world settings. Here, we describe an opportunistic approach using dried blood spots (DBS) to evaluate a population pharmacokinetic model metronidazole preterm infants gestational age (GA) ≤31 weeks from Metronidazole Pharmacokinetics Premature Infants (PTN_METRO, NCT01222585) study. First, used...
To determine whether bisphenol S (BPS), a common substitute for A (BPA), induces cell proliferation and migration in human endometrial epithelial cells (Ishikawa) adult mouse uterine tissues.Human Ishikawa were exposed to low doses of BPS (1 nM 100 nM) 72 hours. Cell was assessed through the viability assays MTT CellTiter-Glo®. Wound healing also used evaluate potential line. The expression genes related determined. Similarly, mice at dose 30 mg/kg body weight/day 21 days, after which,...
Abstract Introduction: In phase 2 studies (NCT02296684 and NCT02641093), neoadjuvant adjuvant pembrolizumab demonstrated pathologic response acceptable safety in high-risk, resectable locally advanced (LA) head neck squamous cell carcinoma (HNSCC). KEYNOTE-689 (NCT03765918) is a randomized, open-label, 3 trial designed to evaluate plus standard of care (SOC) previously untreated LA HNSCC. Materials Methods: Eligible patients have histologically confirmed, newly diagnosed, resectable, HNSCC...
Intraperitoneal injection of endometrial tissues into inbred mice such as C57BL/6J is widely used a model to study endometriosis, disease characterized by the abnormal proliferation cells which invade various within peritoneal cavity. However, most these mouse strains have weak immune system and are often ovariectomized, not reflective human population in general. Hence, this ovary intact ICR strain response during endometriosis development using non-surgical syngeneic with no estrogen...