A5004248968- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Nanoplatforms for cancer theranostics
- Intestinal and Peritoneal Adhesions
- Drug Solubulity and Delivery Systems
- Hernia repair and management
- Dendrimers and Hyperbranched Polymers
- Surgical Sutures and Adhesives
- Bacterial biofilms and quorum sensing
- Diabetes Management and Research
- Cancer Research and Treatment
- Ion Channels and Receptors
- Barrier Structure and Function Studies
- Pharmacological Effects and Toxicity Studies
- RNA Interference and Gene Delivery
- 3D Printing in Biomedical Research
- Diabetes Treatment and Management
- Lipid Membrane Structure and Behavior
- Sensor Technology and Measurement Systems
- Pain Mechanisms and Treatments
- Power Transformer Diagnostics and Insulation
- Pickering emulsions and particle stabilization
- Botulinum Toxin and Related Neurological Disorders
- Graphene and Nanomaterials Applications
- Antimicrobial agents and applications
Brigham and Women's Hospital
2025
Harvard University
2025
Wayne State University
2019-2023
Shenyang Pharmaceutical University
2015-2019
National Research Council Canada
2002
Significance Postoperative peritoneal adhesions are frequent complications for almost any types of abdominal and pelvic surgery lead to numerous medical problems. Current antiadhesion solutions include pharmacological treatment physical barriers but underperformed can only alleviate or reduce some extent. Here we show that a zwitterionic polymer solution after convenient topical application onto the traumatized surface reliably completely prevent postoperative adhesions, as demonstrated in...
Postoperative peritoneal adhesions were frequent complications for almost any types of abdominal and pelvic surgery. This led to numerous medical problems huge financial burden the patients. Current anti-adhesion strategies focused mostly on physical barriers including films hydrogels. However, they can only alleviate or reduce certain level their applying processes far from ideal. work reported development a biodegradable zwitterionic cream gel presenting series characters an idea material,...
Recently, nanomedicine without drug carriers has attracted many pharmacists' attention. A novel paclitaxel–s–s–paclitaxel (PTX–s–s–PTX) conjugate with high loading (∼78%, w/w) was synthesized by conjugating paclitaxel to using disulfide linkage. The could self-assemble into uniform nanoparticles (NPs) 1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide (DiR) encapsulated within the core of PTX–s–s–PTX NPs for photothermal therapy (PTT). DiR-loaded self-assembled (DSNs) had a mean...
Citronellol-cabazitaxel (CIT-ss-CTX) conjugate self-assembled nanoparticles (CSNPs) were designed and prepared by conjugating cabazitaxel with citronellol via the disulfide bond that is redox-sensitive to high concentration of glutathione within tumor cells. Notably, CSNPs maintained in cell cytotoxicity. Moreover, AUC0-t was 6.5-fold higher than solutions t1/2 prolonged 2.3 times. Furthermore, we found could be employed as an efficient carrier for other hydrophobic drugs or imaging agents....
To improve the bioavailability of orally administered drugs, we synthesized a pH-sensitive polymer (poly(ethylene glycol)–poly(2-methyl-2-carboxyl-propylene carbonate)–vitamin E, mPEG–PCC–VE) attempting to integrate advantages enteric coating and P-glycoprotein (P-gp) inhibition. The aliphatic polycarbonate chain was functionalized with carboxyl groups vitamin E via postpolymerization modification. Optimized by comparison central composite design, mPEG113–PCC32–VE4 exhibited low critical...
Sensory neurons within the dorsal root ganglion (DRG) are primary trigger of pain, relaying activity about noxious stimuli from periphery to central nervous system; however, targeting DRG for pain management has remained a clinical challenge. Here, we demonstrate use lipid nanoparticles (LNPs) effective intrathecal delivery small interfering RNA (siRNA) neurons, achieving potent silencing transient receptor potential vanilloid 1 (TRPV1) ion channel that is predominantly expressed in...
Star-shape paclitaxel prodrugs self-assembled nanoparticles combining high drug loading and enhanced cytotoxicity.
A subject of considerable interest at the present time is development diagnostic techniques to assess operating state and predict remaining life electrical power equipment in service. Such can help reduce unscheduled outages, improve maintenance planning increase system reliability. The a high voltage apparatus usually depends upon its insulation. An analysis fundamental dielectric processes has shown that polarization phenomena are strongly influenced by morphology degradation polymeric...