A5004265300- Chemokine receptors and signaling
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Diabetes Management and Research
- RNA modifications and cancer
- Neuropeptides and Animal Physiology
- Cytokine Signaling Pathways and Interactions
- Inflammatory mediators and NSAID effects
- Single-cell and spatial transcriptomics
- Receptor Mechanisms and Signaling
- Cancer, Hypoxia, and Metabolism
- Sirtuins and Resveratrol in Medicine
- Microbial Natural Products and Biosynthesis
- Advanced biosensing and bioanalysis techniques
- Neurogenesis and neuroplasticity mechanisms
- TGF-β signaling in diseases
- interferon and immune responses
- Genomics, phytochemicals, and oxidative stress
- Pediatric Pain Management Techniques
- Pluripotent Stem Cells Research
- Analytical Chemistry and Sensors
- Cancer, Stress, Anesthesia, and Immune Response
Brigham and Women's Hospital
2025
Harvard University
2025
Korea University
2017-2024
Florida State University
2021-2024
University of Houston
2020
Kyung Hee University
2020
Tohoku University
2020
Wonkwang University
2020
Sookmyung Women's University
2016-2017
Some chemokine receptors referred to as atypical (ACKRs) are thought non-signaling decoys because of their inability activate typical G-protein signaling pathways. CXCR7, also known ACKR3, binds only two chemokines, SDF-1α and I-TAC, recruits β-arrestins. its own conventional receptor, CXCR4, involving in homeostatic modulation such development immune surveillance well pathological conditions inflammation, ischemia, cancers. Recently, CXCR7 is suggested a key therapeutic target together with...
Despite the established comorbidity between mood disorders and abnormal eating behaviors, underlying molecular mechanism therapeutics remain to be resolved. Here, we show that a spexin-based galanin receptor type 2 agonist (SG2A) simultaneously normalized behaviors body weight in corticosterone pellet-implanted (CORTI) mice, which are underweight exhibit signs of anhedonia, increased anxiety, depression. Administration SG2A into lateral ventricle produced antidepressive anxiolytic effects...
Sensory neurons within the dorsal root ganglion (DRG) are primary trigger of pain, relaying activity about noxious stimuli from periphery to central nervous system; however, targeting DRG for pain management has remained a clinical challenge. Here, we demonstrate use lipid nanoparticles (LNPs) effective intrathecal delivery small interfering RNA (siRNA) neurons, achieving potent silencing transient receptor potential vanilloid 1 (TRPV1) ion channel that is predominantly expressed in...
FAM19A5 is a secretory protein that predominantly expressed in the brain. Although gene has been found to be associated with neurological and/or psychiatric diseases, only limited information available on its function Using FAM19A5-LacZ knock-in mice, we determined expression pattern of developing and adult brains identified cell types express naïve traumatic brain injury (TBI)–induced brains. According X-gal staining results, ventricular zone ganglionic eminence at very early stage...
Epidemiology studies demonstrate that women are at a significantly lower risk of developing type 2 diabetes (T2D) compared to men. However, the molecular basis this difference is not well understood. In study, we examined sex differences in genetic programs pancreatic endocrine cells. We combined pancreas perifusion data and single-cell genomic from our laboratory publicly available sets investigate multiple axes human level. systematically female male islet secretion function, gene...
Abstract Breast cancer exhibits high lethality in women because it is frequently detected at an advanced stage and aggressive forms such as triple-negative breast (TNBC), which are often characterized by metastasis through colonization of secondary tumors. Thus, developing therapeutic agents that target the metastatic process crucial to successfully treat cancer. We evaluated SP-8356, anti-inflammatory synthetic verbenone derivative, with respect its regulation cell behavior progression....
The goal of this study was to investigate whether circulating C1q/TNF-α-related protein 1 (CTRP1) levels are associated with diabetes. In addition, relationships between CTRP1 and other diabetes-related cytokines were elucidated, including adiponectin fibroblast growth factor 21 (FGF21). A total 178 subjects (78 men 100 women) aged 29-70 years (mean age, 46.1 years) randomly selected. sera from a normal glucose tolerance group (n = 68) prediabetes/type 2 diabetes 110) collected; then, CTRP1,...
Lan Phuong Nguyen, Huong Thi Hyo Jeong Yong, Arfaxad Reyes-Alcaraz, Yoo-Na Lee, Hee-Kyung Park, Yun Hee Na, Cheol Soon Byung-Joo Ham, Jae Young Seong, and Jong-Ik Hwang. Mol. Cells 2020;43:909-20. https://doi.org/10.14348/molcells.2020.0144
Abstract Neurodevelopment and mature brain function are spatiotemporally regulated by various cytokines chemokines. The chemokine-like neuropeptide FAM19A1 is a member of family with sequence similarity 19 (FAM19), which predominantly expressed in the brain. Its highly conserved amino acid among vertebrates suggests that may play important physiological roles neurodevelopment function. Here we used LacZ reporter gene system to map expression pattern mouse was observed several regions...
NEUROGENIN3+ (NEUROG3+) cells are considered to be pancreatic endocrine progenitors. Our current knowledge on the molecular program of NEUROG3+ in humans is largely extrapolated from studies mice. We hypothesized that single-cell RNA-seq enables in-depth exploration rare directly humans. aligned four large datasets postnatal human pancreas. integrated analysis revealed 10 epithelial a total 11,174 cells. Noticeably, clustered with mature and epsilon displayed highest frequency NEUROG3...
Dong Hwi Kim, Hyo Jeong Yong, Sunam Mander, Huong Thi Nguyen, Lan Phuong Hee-Kyung Park, Kyeong Cha, Won-Ki Kim,* and Jong-Ik Hwang,*. Biomolecules & Therapeutics 2021;29:331-41. https://doi.org/10.4062/biomolther.2020.200
ABSTRACT FAM19A5 is a novel secretory protein primarily expressed in the brain. However, recent study reported that an adipocyte-derived adipokine regulates vascular smooth muscle function through sphingosine-1-phosphate receptor 2 (S1PR2). In our study, we investigated transcript and levels peripheral tissues, including adipose from wild-type, knockout, LacZ knockin mice. We found central nervous system were much greater than those any of tissues. Furthermore, reproductive tissues below...
// Hyo Jeong Yong 1 , Su Park 2 Ae Lee Sora Han Sunyi Hye In Ka Buyanravjkh Sumiyasuren Hyun Joo So Ji Young Do-Young Yoon 3 Jong-Seok Lim Myeong-Seok Hee Gu 4 and Yang Department of Biological Sciences, Sookmyung Women's University, Seoul, Republic Korea Severance Biomedical Science Institute, Yonsei Research University College Medicine, Bioscience Biotechnology, Bio/Molecular Informatics Center, Konkuk Immunotherapy Convergence Institute Daejeon, Correspondence to: Yang, email:...
Current approaches to profile the single-cell transcriptomics of human pancreatic endocrine cells almost exclusively rely on freshly isolated islets. However, islets are limited in availability. Furthermore, extensive processing steps during islet isolation and subsequent single cell dissolution might alter gene expressions. In this work, we report development a single-nucleus RNA sequencing (snRNA-seq) approach with targeted enrichment for endocrine-population focused transcriptomic...
FAM19A5 is a novel secretory protein expressed primarily in the brain. However, recent study reported that an adipocyte-derived adipokine regulates vascular smooth muscle function through sphingosine-1-phosphate receptor 2 (S1PR2). In our study, we investigated transcript and levels peripheral tissues, including adipose from wild-type, knockout, FAM19A5-LacZ knockin mice. We found central nervous system were much greater than those any of tissues. Furthermore, reproductive tissues below...
Abstract Background: Some chemokine receptors referred to as atypical (ACKRs) are thought non-signaling decoys because of their inability activate typical G-protein signaling pathways. CXCR7, also known ACKR3, binds only two chemokines, SDF-1a and I-TAC, recruits b-arrestins. its own conventional receptor, CXCR4, involving in homeostatic modulation such development immune surveillance well pathological condition inflammation, ischemia, cancers. Recently, CXCR7 is suggested a key therapeutic...
Abstract Background Some chemokine receptors referred to as atypical (ACKRs) are thought non-signaling decoys because of their inability activate typical G-protein signaling pathways. It is generally accepted that main role focuses on scavenging several chemokines limit spatial availability in biological processes. CXCR7, also known ACKR3, unlike other ACKRs, binds only two chemokines, SDF-1α and I-TAC, recruits β-arrestins plasma membrane. Other than its own conventional receptor, CXCR4,...