A5018042732- Gold and Silver Nanoparticles Synthesis and Applications
- Biosensors and Analytical Detection
- Spectroscopy Techniques in Biomedical and Chemical Research
- Machine Learning in Materials Science
- Metabolomics and Mass Spectrometry Studies
- Protein Interaction Studies and Fluorescence Analysis
- Advanced Chemical Sensor Technologies
- SARS-CoV-2 detection and testing
- Spectroscopy and Chemometric Analyses
- Catalytic Processes in Materials Science
- Solar-Powered Water Purification Methods
- Copper-based nanomaterials and applications
- Olfactory and Sensory Function Studies
- Data Stream Mining Techniques
- Nanoparticle-Based Drug Delivery
- Nanocluster Synthesis and Applications
- Mass Spectrometry Techniques and Applications
- COVID-19 diagnosis using AI
Nanyang Technological University
2021-2024
Population-wide surveillance of COVID-19 requires tests to be quick and accurate minimize community transmissions. The detection breath volatile organic compounds presents a promising option for but is currently limited by bulky instrumentation inflexible analysis protocol. Here, we design hand-held surface-enhanced Raman scattering-based breathalyzer identify infected individuals in under 5 min, achieving >95% sensitivity specificity across 501 participants regardless their displayed...
Integrating machine learning with surface-enhanced Raman scattering (SERS) accelerates the development of practical sensing devices. Such integration, in combination direct detection or indirect analyte capturing strategies, is key to achieving high predictive accuracies even complex matrices. However, in-depth understanding spectral variations arising from specific chemical interactions essential prevent model overfit. Herein, we design a machine-learning-driven "SERS taster" simultaneously...
Gas-phase surface-enhanced Raman scattering (SERS) remains challenging due to poor analyte affinity SERS substrates. The reported use of capturing probes suffers from concurrent inconsistent signals and long response time the formation multiple potential probe-analyte interaction orientations. Here, we demonstrate non-covalent interactions for ring complexation boost small gas molecules, SO2 NO2 , our platform, achieving rapid capture multiplex detection down 100 ppm. Experimental in-silico...
Schematic of our bidirectional, ML-empowered approach incorporating plasmonic featurization for rapid (<30 s) and accurate determination the size distribution gold nanosphere (Au NSs) ensembles in real samples.
Molecular recognition of complex isomeric biomolecules remains challenging in surface-enhanced Raman scattering (SERS) spectroscopy due to their small cross-sections and/or poor surface affinities. To date, the use molecular probes has achieved excellent sensitivities but still suffers from spectral specificity. Here, we induce "charge and geometry complementarity" between probe analyte as a key strategy achieve high specificity for effective SERS structural analogues. We employ...
Abstract Nanoparticle (NP) characterization is essential because diverse shapes, sizes, and morphologies inevitably occur in as‐synthesized NP mixtures, profoundly impacting their properties applications. Currently, the only technique to concurrently determine these structural parameters electron microscopy, but it time‐intensive tedious. Here, we create a three‐dimensional (3D) space purity, size, shape of 1000 sets Ag nanocubes mixtures containing interfering nanospheres nanowires from...
Nanoparticle (NP) characterization is essential because diverse shapes, sizes, and morphologies inevitably occur in as-synthesized NP mixtures, profoundly impacting their properties applications. Currently, the only technique to concurrently determine these structural parameters electron microscopy, but it time-intensive tedious. Here, we create a three-dimensional (3D) space purity, size, shape of 1000 sets Ag nanocubes mixtures containing interfering nanospheres nanowires from extinction...
Abstract Molecular recognition of complex isomeric biomolecules remains challenging in surface‐enhanced Raman scattering (SERS) spectroscopy due to their small cross‐sections and/or poor surface affinities. To date, the use molecular probes has achieved excellent sensitivities but still suffers from spectral specificity. Here, we induce “charge and geometry complementarity” between probe analyte as a key strategy achieve high specificity for effective SERS structural analogues. We employ...
‘Plasmonic bubbles’ as a versatile, air-stable, centimetre-sized 3D SERS platform with bi-directional gas sensing capabilities.