A5047900689- Nanoplatforms for cancer theranostics
- Advanced Polymer Synthesis and Characterization
- Advancements in Transdermal Drug Delivery
- Luminescence and Fluorescent Materials
- Topic Modeling
- Natural Language Processing Techniques
- Advanced Graph Neural Networks
- Thyroid Cancer Diagnosis and Treatment
- Text Readability and Simplification
- Photopolymerization techniques and applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Advanced Fluorescence Microscopy Techniques
- Supramolecular Chemistry and Complexes
- Dendrimers and Hyperbranched Polymers
- 2D Materials and Applications
- Head and Neck Anomalies
- Thyroid and Parathyroid Surgery
- Antimicrobial agents and applications
- Radiomics and Machine Learning in Medical Imaging
- Brain Tumor Detection and Classification
- Graph Theory and Algorithms
- MXene and MAX Phase Materials
- Inhalation and Respiratory Drug Delivery
- Environmental remediation with nanomaterials
Sun Yat-sen University
2022-2025
Shanghai Tenth People's Hospital
2025
Tongji University
2025
Sixth Affiliated Hospital of Sun Yat-sen University
2024
First People's Hospital of Foshan
2024
Puer University
2024
Hefei University of Technology
2024
Shanghai Institute of Ceramics
2020-2022
Chinese Academy of Sciences
2020-2022
University of Shanghai for Science and Technology
2020-2022
Antibiotic resistance has become a critical health crisis globally. Traditional strategies using antibiotics can lead to drug-resistance, while inorganic antimicrobial agents cause severe systemic toxicity. Here, we have developed dual-antibiotic hydrogel delivery system (PDA-Ag@Levo/CMCS), which achieve controlled release of clinical levofloxacin (Levo) and classic nanoscale antibiotic silver nanoparticles (AgNPs), effectively eliminating drug-resistant P. aeruginosa. Benefiting from the...
Abstract Hydrogen therapy, as a star therapeutic modality, has recently acquired much attention in the field of anticancer medicine. Evidence suggests that hydrogen can selectively reduce intratumoral overexpressed hydroxyl radicals (•OH) to break redox homoeostasis and thereby result stress cell damage. As reactive oxygen species‐related noninvasive photodynamic therapy (PDT) been approved for varied tumor treatments clinically. For implementing with enhanced efficacy attenuated side...
A soluble microneedle system loaded with two-dimensional MXene has been successfully fabricated, which can achieve<italic>in-situ</italic>photothermal therapy towards superficial tumor models minimal invasion and high efficiency of drug delivery.
Abstract As the emerging modalities for tumor therapy, sonodynamic therapy (SDT) and chemodynamic (CDT) can generate reactive oxygen species (ROS), typically inducing cell apoptosis. However, construction of more efficient sonosensitizers integrated with excellent Fenton/Fenton‐like catalytic activity to improve synergistic therapeutic effect SDT CDT is still highly challenging. In this study, 2D semiconductor FePS 3 nanosheets (NSs), as one metal phosphorus trichalcogenides both...
Abstract The healing of bacterial biofilm‐infected wounds is a complex process, and the construction emerging therapeutic modalities that regulate microenvironment to magnify effects reduce biotoxicity still highly challenging. Herein, an engineered microneedle (MN) patch reported mediate efficient delivery black phosphorus nanosheets (BP NSs) copper peroxide nanodots (CP NDs) for dual nanodynamic sterilization methicillin‐resistant staphylococcus aureus (MRSA)‐infected wound healing....
ABSTRACT As one of the emerging techniques for preparing discrete oligomers, photo‐RAFT single unit monomer insertion (SUMI) process has shown its uniqueness and superiority in control both sequence stereochemistry. However, current precision polymer synthesis are still burdened by scalability challenges, such as low reaction yields, small product quantities, long production times. Herein, we successfully established a practical protocol to address problems SUMI processes. A series oligomers...
Reversible deactivation radical polymerization (RDRP) techniques regulate free through a process of reversible activation/deactivation propagating radicals, which thus provides dormant polymer chains with unique capping moieties (alkoxyamine, halogen, thiocarbonylthio, etc.) as chain ends. The ends are the reactive sites initiation, propagation, and termination, therefore their chemical structures crucial for mechanism kinetics RDRP. investigation stereochemical effects is challenging due to...
Reversible addition-fragmentation chain transfer (RAFT) single unit monomer insertion (SUMI) of β-methylstyrene derivatives into diverse RAFT agents presented fast reaction kinetics, but significant degradation the SUMI products occurred due to a hydrogen abstraction reaction. Fortunately, such can be suppressed through appropriate design initial attributed effective and selective photoactivation.
Introduction With the increasing demand for protein utilization, exploring new resources has become a research hotspot. Sacha Inchi Protein (SIP) is high-quality plant extracted from meal. This study aimed to investigate impact of SIP on mouse metabolomics and gut microbiota diversity explore underlying pathways responsible its health benefits. Methods In this study, structural composition was investigated, effects fecal intestinal microorganisms in mice were explored by LC–MS technology...
The presence of lateral lymph node metastases (LNM) in paediatric patients with papillary thyroid cancer (PTC) is an independent risk factor for recurrence. We aimed to identify factors and establish a prediction model LNM before surgery children adolescents PTC.
Photoinduced reversible addition–fragmentation chain transfer (photo-RAFT) polymerization combines conventional RAFT with photochemistry, in which the carbon radicals (R radicals) are generated from agents (except cases using external radical photoinitiators) by direct photolysis or photoredox catalysis. As one of key components, agent is responsible for living control photo-RAFT and various reaction kinetics processes activation/deactivation, propagation, termination. Despite considerable...
Question generation (QG) aims to automatically generate fluent and relevant questions, where the two most mainstream directions are generating questions from unstructured contextual texts (CQG), such as news articles, structured factoid (FQG), knowledge graphs or tables. Existing methods for these tasks mainly face challenges of limited internal structural information well scarce background information, while can benefit each other alleviating issues. For example, when meeting entity mention...
<title>Abstract</title> Background Lateral lymph node metastases (LNM) for pediatric patients with papillary thyroid cancer (PTC) is an independent risk factor recurrence. We aimed to identify factors and establish a prediction model lateral LNM before surgery in children adolescents PTC. Methods A retrospective cohort study was conducted data obtained from 63 minors PTC between 2014 2023. The clinical factors, ultrasound (US) features of primary tumor, pathology records were collected...
Controllable Text Generation (CTG) has obtained great success due to its fine-grained generation ability by focusing on multiple attributes. However, most existing CTG researches overlook how utilize the attribute entanglement enhance diversity of controlled generated texts. Facing this dilemma, we focus a novel scenario, i.e., blessing which is challenging because high-quality texts require models comprehensively consider between attributes (e.g., objects and occasions). To promote research...
Controllable Text Generation (CTG) has obtained great success due to its fine-grained generation ability by focusing on multiple attributes. However, most existing CTG researches overlook how utilize the attribute entanglement enhance diversity of controlled generated texts. Facing this dilemma, we focus a novel scenario, i.e., blessing which is challenging because high-quality texts require models comprehensively consider between attributes (e.g., objects and occasions). To promote research...