Although enteric glial cells (EGCs) have been demonstrated to play a key role in maintaining intestinal epithelial barrier integrity, it is not known how EGCs regulate this integrity. We therefore hypothesized that glial-derived neurotrophic factor (GDNF) produced by might be involved regulation. Here we investigated the of GDNF regulating function vivo. Recombinant adenoviral vectors encoding (Ad-GDNF) were administered intracolonically experimental colitis induced dextran sulphate sodium...

This study aimed to investigate the expression levels and clinical implications of interferon α inducible protein 27 (IFI27) N6-methyladenosine (m6A) regulator Alkylation repair homolog 5 (ALKBH5) in head neck squamous cell carcinoma (HNSCC). We employed bioinformatics methods analyze differential IFI27 HNSCC its prognostic implications. Additionally, we explored pathways mechanisms associated with enrichment. Immunohistochemistry (IHC) was used detect adjacent normal tissues. significantly...

The aim of this study was to explore the key genes, microRNA (miRNA), and pathogenesis oral squamous cell carcinoma (OSCC) at molecular level through analysis bioinformatics, which could provide a theoretical basis for screening drug targets. Data OSCC were obtained from Gene Expression Omnibus (GEO) database. differentially expressed genes (DEGs) identified via GEO2R analysis. Next, protein–protein interaction (PPI) network DEGs constructed Search Tool Retrieval Interacting visualized...

Abstract The tumor microenvironment (TME) is of great clinical significance for predicting the therapeutic effect tumors. Nonetheless, there was no systematic analysis cellular interactions in TME head and neck cancer (HNSC). This study used gene expression data from 816 patients with HNSC to analyze scores 22 immune cells. On this basis, we have established a novel TMEscore-based prognostic risk model. relationship between TMEscore genomic characteristics analyzed. sample divided into...

Oral squamous cell carcinoma (OSCC) is a malignant tumor that occurs in oral cavity and dominated by cells. The relationship between CDK1, CCNA2, OSCC still unclear. datasets GSE74530 GSE85195 configuration files were downloaded from the Gene Expression Omnibus (GEO) database derived platforms GPL570 GPL6480. Differentially expressed genes (DEGs) screened. weighted gene co-expression network analysis, functional enrichment set construction analysis of protein–protein interaction (PPI)...

Abstract Astragalus membranaceus (HUANG QI, HQ) is a kind of traditional Chinese medicine. Researchers have widely concerned its antitumor effect. At present, there still lack research on the treatment laryngeal cancer with HQ. In this study, we integrated data from weighted gene co-expression network samples and components targets A new method for dividing PPI modules proposed. Important HQ were obtained through screening critical modules. These nodes performed differential expression...

Tongue squamous cell carcinoma (TSCC) is one of the most common malignant tumors in head and neck, but its molecular mechanism not clear.Weighted gene co-expression network analysis (WGCNA) combining with differential expression analysis, survival to screen key modules hub genes related progress TSCC. Gene Set Enrichment Analysis (GSEA) was used identify biological pathways that might be involved.Weighted constructed based on dataset GSE34105. The blue module turquoise TSCC were identified...

Adenoid cystic carcinoma (ACC) is a tumor type derived from glands. However, relationship between CCNA2 and KIF23, adenoid remains unclear.

The present study aimed to determine changes in the concentration of secretory immunoglobulin A (SIgA) and interleukin 6 (IL-6) saliva patients with oral cancer, evaluate abnormal expression cluster differentiation (CD) 1a, CD83, CD80 CD86 on dendritic cells (DCs) cancer tissues discuss interaction between SIgA, IL‑6 DCs cancer. total 40 27 70 years age, median age 52 years, primary were enrolled study, a group 20 healthy male female volunteers was used as control group. SIgA preoperative...

Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors head and neck. Programmed death protein 1 (PD-1), programmed ligand (PD-L1) are often overexpressed in OSCC patients, their expression level closely related to tumor prognosis. The objectives this study were: 1) evaluate impact anti-PD-1 treatment on immune system prognosis patients 2) find possible associations between T-cell immunity therapy.A total 120 (divided into two equal groups: "non-anti-PD1 therapy"...

Oral cancer is one of the most common malignant tumors in head and neck. It easy to relapse, prognosis poor. However, molecular mechanism development oral still unclear.A total 30 normal individuals patients with neck who underwent surgery were recruited Fourth Hospital Hebei Medical University between February 2019 November 2021. Furthermore, Human Protein Atlas (HPA) analysis, RT-qPCR, immunofluorescence used verify expression SOX9 IL1A. The GSE69002 dataset was downloaded from Gene...

Oral squamous cell carcinoma is a malignant tumor that occurs in the oral cavity, with poor prognosis and easy recurrence. However, relationship between MKI67 remains unclear. The datasets GSE138206, GSE146483 GSE184616 were downloaded from gene expression omnibus database, differentially expressed genes (DEGs) screened. protein-protein interaction network was constructed analyzed by search tool for retrieval of interacting database Cytoscape software. Gene ontology (GO) Kyoto encyclopedia...

Tongue squamous cell carcinoma (TSCC) is one of the most common malignant tumor types in oral and maxillofacial region. The etiology pathogenesis behind TSCC complicated. In present study, three gene expression profiles, namely GSE31056, GSE13601 GSE78060, were downloaded from Gene Expression Omnibus (GEO). GEO2R online tool was utilized to identify differentially expressed genes (DEGs) between normal tissue samples. Furthermore, a protein‑protein interaction (PPI) network constructed hub...

The relationship between oral squamous cell carcinoma (OSCC) and Corneodesmosin (CDSN) remains unclear. This study aims to explore the correlation CDSN prognosis survival time of patients with OSCC.Bioinformatics were used identify hub role in OSCC. A total 200 OSCC recruited. Clinical follow-up data recorded, expression level was detected. Pearson chi-square test Spearman coefficient analyze related parameters Univariate multivariate Logistic regression Cox proportional risk applied for...

Oral squamous cell carcinoma (OSCC) is a malignant tumor occurring in the oral cavity. However, molecular mechanism of OSCC not clear. Bioinformatics was used to screen and identify role collagen type X1 alpha 1 (COL11A1) on OSCC. 200 patients with were recruited. Clinical follow-up data recorded COL11A1 expression levels tested. Pearson chi-square test Spearman correlation coefficient analyze relationship between prognosis related parameters Univariate multivariate Logistic regression,...

This study aimed to explore the target relationship between miR-204-5p and bromodomain-containing protein (BRD) 4, as well their effects on cell proliferation, migration, invasion in tongue squamous carcinoma SCC25.

Analog front-end (AFE) circuits play an important role in the acquisition of physiological signals with low-level amplitudes (from tens μV to mV) and broadband low-frequency ranges sub-Hz several hundred Hz). Possessing a high input impedance, instrumentation amplifier (IA) accurately amplifies low amplitude frequency, making it suitable for AFE circuits. This work demonstrates capacitively coupled IA whose feedback resistance is realized by proposed hybrid resistor, consisting...