A5014374360- Cancer Immunotherapy and Biomarkers
- Hepatitis C virus research
- Lung Cancer Research Studies
- Advanced Malware Detection Techniques
- Lung Cancer Treatments and Mutations
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- CAR-T cell therapy research
- Acute Myeloid Leukemia Research
- Gastric Cancer Management and Outcomes
- Prostate Cancer Treatment and Research
- Chronic Disease Management Strategies
- Cutaneous Melanoma Detection and Management
- Melanoma and MAPK Pathways
- Software Engineering Research
- Lung Cancer Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
- Radiomics and Machine Learning in Medical Imaging
- Antiplatelet Therapy and Cardiovascular Diseases
- Peptidase Inhibition and Analysis
- Liver Disease Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Economic and Financial Impacts of Cancer
- Head and Neck Cancer Studies
- Pancreatic and Hepatic Oncology Research
Bryn Mawr College
2024
Central Coast Local Health District
2024
Hanoi Medical University
2024
Viet Duc Hospital
2024
Bristol-Myers Squibb (United States)
2013-2023
Predictive Science (United States)
2023
Northern Cancer Institute
2023
Coffs Harbour City Council
2023
Eli Lilly (United States)
2007-2012
Thomson Reuters (United States)
2011
The real-world effect of anti-programmed death ligand 1 (PD-L1) therapies is unclear. We compared US patients who received second-line therapy for non-small-cell lung cancer (NSCLC) before and shortly after Food Drug Administration (FDA) approval PD-L1 inhibitors.Patients in the Flatiron Health database (≥18 years; first-line platinum advanced/metastatic NSCLC; ≥6 months follow-up) were assessed ("historical": January 1, 2011 to December 31, 2013) ("current": 2015 May 2017) FDA anti-PD-L1...
ABSTRACTObjective: To estimate the point prevalence of diabetic peripheral neuropathy (DPN) and pain associated with DPN (pDPN) in French adults diabetes compare severity symptoms across demographic subpopulations.Design: The participant-administered portion Michigan Neuropathy Screening Instrument (MNSI) selected items Brief Pain Inventory (BPI) formed part a computer-aided telephone survey posed to representative, random sample households from March 1, 2005 April 30, 2005. Questions MNSI...
Osteoarthritis is a chronic debilitating condition affecting many adults in the United States. This study was to compare pharmacologic treatments and costs for newly diagnosed existing osteoarthritis patients assess unmet medication treatment needs economic burden.This retrospective analysis of de-identified medical pharmacy insurance claims from MarketScan(®) databases identified adult with an claim 2007. The date first 2007 served as index. Patients were stratified into cohorts, based on...
Data on the treatment of non-small cell lung cancer (NSCLC) in real-world clinical practice Japan are limited. This large-scale, retrospective cohort study examined data patients' characteristics and systemic therapies for advanced or recurrent NSCLC routine Japan.This used an electronic health records-based database claims Diagnosis Procedure Combination from 215 consenting hospitals Japan. Records April 2008 to September 2015 were analyzed. Regimens by histology, age, sex, therapeutic...
Due to the ubiquity of computer software, software vulnerability detection (SVD) has become crucial in industry and field security. Two significant issues SVD arise when using machine learning, namely: i) how learn automatic features that can help improve predictive performance ii) overcome scarcity labeled vulnerabilities projects require laborious labeling code by security experts. In this paper, we address these two concerns proposing a novel architecture which leverages deep domain...
BackgroundFirst-line (1L) and second-line (2L) therapies for advanced/metastatic gastric cancer (GC) gastroesophageal junction (GEJC) have modest efficacy, therapeutic options in subsequent lines are limited as disease progresses. We assessed real-world treatment patterns outcomes GC/GEJC.Patients MethodsAdult patients diagnosed with GC/GEJC between January 1, 2011 April 30, 2018 were identified using the Flatiron Health database. Median overall survival (OS) from start of each line therapy...
Abstract Study question Is any hormone stimulation needed to treat infertility in women with polycystic ovary syndrome (PCOS) using vitro maturation (IVM)? Summary answer Number of matured oocytes and pregnancy outcomes were similar without or FSH-priming PCOS undergoing IVM. What is known already In (IVM) a low-intervention alternative fertilisation (IVF) for treatment. Current standard clinical practice human IVM prime patients 2–5 days follicle-stimulating (FSH) and/or chorionic...
To characterize treatment patterns and measure the economic burden associated with metastatic (mHNC) recurrent, locally-advanced head neck cancer (rHNC).Administrative claims from Medicare- privately-insured individuals during 2004-2008 were used in this retrospective database study of patients advanced HNC. Patients diagnosed HNC matched 1:1 to cancer-free controls incremental Outcomes interest measured 6 months following date a secondary tumor diagnosis for or indicating rHNC. assess...
Abstract Background Ipilimumab has shown long-term overall survival (OS) in patients with advanced melanoma clinical trials, but robust real-world evidence is lacking. We present outcomes from the IMAGE study (NCT01511913) receiving ipilimumab and/or non-ipilimumab (any approved treatment other than ipilimumab) systemic therapies. Methods was a multinational, prospective, observational assessing adult treated or therapies between June 2012 and March 2015 ≥3 years of follow-up. Adjusted OS...
Patients with glioblastoma multiforme (GBM) have a poor prognosis and high likelihood of recurrence. Routine care for incident cases in the United States involves surgical resection, followed by radiation therapy (RT) concurrent adjuvant temozolomide. Real-world data reporting treatments health burden associated GBM are limited.To assess patterns care, resource utilization (HCRU), costs treatment States.This study is retrospective claims database analysis. Adult patients diagnosis (index...
To descriptively analyze patient characteristics, treatment patterns, and medical resource use of individuals with diabetes mellitus (DM) without comorbid major depressive disorder (MDD).
Abstract Background There are few third-line or later (3L+) treatment options for advanced/metastatic (adv/met) gastric cancer/gastroesophageal junction cancers (GC/GEJC). 3L+ Nivolumab demonstrated encouraging results in Asian patients the ATTRACTION-2 study compared with placebo (12-month survival, 26% vs 11%), and Western single-arm CheckMate 032 44%). This analysis aimed to establish comparator cohorts of US receiving routine care real-world (RW) clinical practice. Methods A 2-step...
BACKGROUND: Chronic hepatitis C (CHC) is associated with substantial morbidity and mortality, the future burden of disease predicted to significantly increase. The recent addition 2 direct-acting antiviral (DAA) protease inhibitors, telaprevir boceprevir, peginterferon alfa (PEG) ribavirin (RBV) therapy has been shown improve sustained virologic response rates thus become standard care. While efficacy safety DAAs assessed in clinical trial setting, less known about real-world use these new...
Available reports of synchronous prostate and bladder cancer have exclusively described radical cystoprostatectomy with or without perioperative chemotherapy as the treatment choice. There are no curative intent definitive chemoradiation therapy for primary cancers. Small cell carcinoma is a rare aggressive tumor. We present first case mixed small urothelial urinary adenocarcinoma in 70-year-old male who attained long-term survival after concurrent chemoradiotherapy minimal acute late...
Introduction: Malabsorption, marked by impaired nutrient absorption, affects both macronutrients and micronutrients, leading to deficiencies gastrointestinal (GI) symptoms. Constipation, a prevalent GI issue in children, increasingly impacts pediatric nutritional health, affecting weight height influencing long-term development. This study investigates the correlation between body mass index (BMI) stool quality aiming inform interventions preschoolers Northern Vietnam.. Methods: A sample...
Current methods of categorising the
Ehlers-Danlos syndrome (EDS) consists of a heterogeneous group congenital collagen formation disorders characterised by skin hyperextensibility, atrophic scarring, and generalized joint hypermobility. Collagen vascular have been implicated in increased incidence severity radiation toxicities; however, there are limited reports on the safety therapy with EDS. We identified all patients EDS who received adjuvant conventional hypofractionated breast at our institution reviewed patient,...