A5067223645- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Ubiquitin and proteasome pathways
- Microbial Natural Products and Biosynthesis
- Cancer-related gene regulation
- Synthetic Organic Chemistry Methods
- Biosensors and Analytical Detection
- Crystallography and molecular interactions
- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- Advanced Causal Inference Techniques
- Plant Disease Resistance and Genetics
- Cancer, Lipids, and Metabolism
- Advanced biosensing and bioanalysis techniques
- Photoacoustic and Ultrasonic Imaging
- Nanomaterials and Printing Technologies
- Machine Learning in Healthcare
- Luminescence and Fluorescent Materials
- Fire Detection and Safety Systems
- Single-cell and spatial transcriptomics
- Laser Material Processing Techniques
- Molecular Sensors and Ion Detection
- Chromosomal and Genetic Variations
- Genetic Mapping and Diversity in Plants and Animals
University of California, Berkeley
2020-2024
Novartis Institutes for BioMedical Research
2023-2024
Novartis (Switzerland)
2023-2024
Innovative Genomics Institute
2023-2024
Liaocheng University
2020-2023
Northeast Normal University
2021
Shanghai Institute of Optics and Fine Mechanics
2018
Anhui University of Technology
2017
Masteel (China)
2017
Syracuse University
2017
In this paper, we propose the first deep reinforcement learning framework to estimate optimal Dynamic Treatment Regimes from observational medical data. This is more flexible and adaptive for high dimensional action state spaces than existing methods model real life complexity in heterogeneous disease progression treatment choices, with goal provide doctor patients data-driven personalized decision recommendations. The proposed contains a supervised step predict most possible expert actions;...
β-catenin (CTNNB1) is an oncogenic transcription factor that important in cell–cell adhesion and of cell proliferation survival genes drive the pathogenesis many different types cancers. However, direct pharmacological targeting CTNNB1 has remained challenging. Here, we have performed a screen with library cysteine-reactive covalent ligands to identify monovalent degrader EN83 depletes ubiquitin-proteasome-dependent manner. We show directly covalently targets three cysteines C466, C520,...
Flexible surface-enhanced Raman spectroscopy (SERS) substrate has attracted great attention due to its convenient sampling and on-site monitoring capability. However, it is still challenging fabricate a versatile flexible SERS substrate, which can be used for in situ detection of analytes either water or on irregular solid surfaces. Here, we report transparent based wrinkled polydimethylsiloxane (PDMS) film obtained by transferring corrugated structures the aluminium/polystyrene bilayer...
Abstract Recent advances suggest that abnormal fatty acid metabolism highly correlates with breast cancer, which provide clues to discover potential biomarkers of cancer. This study aims identify serum free (FFA) metabolic profiles and screen for cancer diagnosis. Gas chromatography–mass spectrometry our in‐house methyl ester standard substances library were combined accurately FFA in samples patients adenosis (as controls). Potential screened by applying statistical analysis. A total 18...
Ophiobolin A (OPA) is a sesterterpenoid fungal natural product with broad anticancer activity. While OPA possesses multiple electrophilic moieties that can covalently react nucleophilic amino acids on proteins, the proteome-wide targets and mechanism of remain poorly understood in many contexts. In this study, we used covalent chemoproteomic platforms to map reactivity highly sensitive lung cancer cell line. Among several proteins engaged, focused two targets: lysine-72 cytochrome c oxidase...
Four multinuclear complexes with different core structures are synthesized. The and photoluminescence properties of M(<sc>ii</sc>)–quinolinate controlled by the substituent groups ligands.
Summary Ophiobolin A (OPA) is a sesterterpenoid fungal natural product with broad anti-cancer activity. While OPA possesses multiple electrophilic moieties that can covalently react nucleophilic amino acids on proteins, the proteome-wide targets and mechanism of remain poorly understood in many contexts. In this study, we used covalent chemoproteomic platforms to map reactivity highly sensitive lung cancer cell line. Among several proteins engaged, focused two targets—cysteine C53 HIG2DA...
With the rapid development of deep learning, object detection technology has been widely used in various fields. Pedestrian detection, as an important part also received attention and development. However, brings a series challenges. The increase information requires higher processing capabilities, lightweight real-time performance have become urgent issues while intelligent video surveillance tends to routine. Therefore, obtaining accurate flow accurately locating pedestrian information,...
Nanogap-rich silver nanoislands with fascinating optical properties are desirable substrates for surface-enhanced Raman scattering (SERS). Here, we propose a simple and high-throughput approach through the laser molecular beam epitaxy (LMBE) technique preparing containing large numbers of intra-nanogaps on silicon wafer (6×6 cm 2 ). By optimizing deposition time, enlarged ∼5 nm interstitial gaps abundance homogeneity were formed. Remarkably, optimized SERS substrate high-density hotspots...
β-catenin (CTNNB1) is an oncogenic transcription factor that important in cell-cell adhesion and of cell proliferation survival genes drives the pathogenesis many different types cancers. However, direct pharmacological targeting CTNNB1 has remained challenging deeming this as "undruggable." Here, we have performed a screen with library cysteine-reactive covalent ligands to identify monovalent degrader EN83 depletes ubiquitin-proteasome-dependent manner. We show directly covalently targets...
Abstract It remains unclear whether the merger of two divergent genomes by hybridization at homoploid level or coupled with whole-genome duplication (WGD; allopolyploidy) can result in plants having better tolerance to stress conditions. In this study, we compared phenotypic performance and gene expression diploid subspecies rice (Oryza sativa subsp. japonica indica), their reciprocal F1 hybrids, segmental allotetraploids under normal nitrogen (N)-deficient We found that hybrids tetraploids...
In this paper, an infrared image restoration algorithm based on the combination of Retinex and CLAHE is proposed to solve problem local detail loss target information blurring caused by uneven illumination image. Firstly, multi-scale used divide into luminance reflection Then, globally compared stretched; For reflected after denoising, enhance its contrast. Finally, processed are weighted fused. The simulation results show that obtained has uniform illumination, clear details, greatly...
In this paper, a new method for constructing zero correlation zone (ZCZ) sequence set is proposed. The proposed can generate two kinds of ZCZ sets. One based on perfect sequence, the other pair. Compared with previous methods, only need an orthogonal matrix order 2 or 3. resulting sets pair are optimal respect to theoretic bound.
Space laser systems are widely used in communication, altimeter and Doppler radar. UV laser, which possesses high spectral resolution provides with the detection of parallel polarized molecular (Rayleigh) particle (Mie) backscattered signals has promising use atmosphere No orbiting satellite carrying 355nm yet been launched owing to induced damage coatings. Coatings for spaceborne system spacecraft improve transmittance optical adjust beams. An effective way lifetime coatings resistance...