A5017290934- Force Microscopy Techniques and Applications
- Autophagy in Disease and Therapy
- Immune cells in cancer
- Mitochondrial Function and Pathology
- Cancer Immunotherapy and Biomarkers
- Alkaloids: synthesis and pharmacology
- Chemical synthesis and alkaloids
- RNA modifications and cancer
- COVID-19 diagnosis using AI
- Advanced biosensing and bioanalysis techniques
- Ferroptosis and cancer prognosis
- Berberine and alkaloids research
- Hydrocarbon exploration and reservoir analysis
- Nanoparticle-Based Drug Delivery
- Endoplasmic Reticulum Stress and Disease
- Cancer-related gene regulation
- Cancer Mechanisms and Therapy
- Advanced Fluorescence Microscopy Techniques
- Lung Cancer Treatments and Mutations
- Mesenchymal stem cell research
- Nanoplatforms for cancer theranostics
- Mechanical and Optical Resonators
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Advanced Nanomaterials in Catalysis
Army Medical University
2016-2025
Chongqing Medical University
2018-2025
Second Affiliated Hospital of Chongqing Medical University
2018-2025
Dalian Medical University
2018-2025
Xinqiao Hospital
2016-2024
Kent State University
2019-2022
Abstract Background Periodontitis is a chronic oral inflammatory disease that seriously affects people's quality of life. The purpose our study was to investigate the correlation between systemic immune inflammation index (SII) and periodontitis by utilizing large national survey. This will establish reference for early identification management periodontitis. Methods comprised adult US population who participated in surveillance project during six years from 2009 2014. Through utilization...
Rho‑associated protein kinase 1 (ROCK1), a member of the ROCK family, serves an important function in cell migration and invasion neoplasms. ROCK1 has been found to be overexpressed several types cancers. However, role non‑small‑cell lung cancer (NSCLC) is poorly understood. In present study, was NSCLC cells tissues, it associated with poor survival patients. Subsequently, knockdown lines were established using shRNA. significantly reduced ability monolayer scratching Transwell assays. also...
Abstract Dopamine deficiency is mainly caused by apoptosis of dopaminergic nerve cells in the substantia nigra midbrain and striatum an important pathologic basis Parkinson’s disease (PD). Recent research has shown that dynamin-related protein 1 (Drp1)-mediated aberrant mitochondrial fission plays a crucial role cell apoptosis. However, upstream regulatory mechanism remains unclear. Our study showed Drp1 knockdown inhibited Importantly, we found ROCK1 was activated MPP + -induced PD model...
Hirsutine extracted from Uncaria rhynchophylla has been shown to exhibit anti-cancer activity. However, the molecular mechanism by which hirsutine exhibits anti-lung cancer activity remains unclear. In present study, we showed that induces apoptosis in human lung cells via loss of mitochondrial membrane potential (∆ψm), adenosine triphosphate (ATP) depletion, ROS production, as well cytochrome c release. Dephosphorylation GSK3β is involved hirsutine-mediated permeability transition pore...
Metastasis is the main cause of death in cancer patients. The efficacy pharmacological therapy for limited by heterogeneous nature cells and lack knowledge microenvironments metastasis. Evidence has shown that activated platelets possess both tumor-homing metastasis-targeting properties via intrinsic cell adhesion molecules on platelets, malaria protein VAR2CSA able to specifically bind oncofetal chondroitin sulfate, which overexpressed with epithelial mesenchymal phenotypes. Inspired these...
Abstract Proliferation and metastasis are significantly malignant characteristics of human lung cancer, but the underlying molecular mechanisms poorly understood. Chromobox 4 (CBX4), a member Polycomb group (PcG) family epigenetic regulatory factors, enhances cellular proliferation promotes cancer cell migration. However, effect CBX4 in progression is not fully We found that highly expressed tumours compared with adjacent normal tissues. Overexpression migration lines. The knockdown...
Abstract IR ‐783 is a kind of heptamethine cyanine dye that exhibits imaging, cancer targeting and anticancer properties. A previous study reported its imaging properties were related to mitochondria. However, the molecular mechanism behind activity has not been well demonstrated. In this study, we showed inhibits cell viability induces mitochondrial apoptosis in human breast cells. Exposure MDA ‐ MB ‐231 cells resulted loss membrane potential ( MMP ), adenosine triphosphate ATP ) depletion,...
Artesunate (ART), a natural product isolated from traditional Chinese plant Artemisia annua, has not been extensively explored for its anti-melanoma properties. In our study, we found that ART inhibited melanoma cell proliferation and induced ferroptosis. Mechanistic study revealed directly targets Ido1, thereby suppressing Hic1-mediated transcription suppression of Hmox1, resulting in CD8+ T cells, does cause ferroptosis due to the low expression Hmox1. It also elevating tryptophan levels,...
Hepatocellular carcinoma (HCC) is the most common primary cancer of liver. Hence, new anti-liver treatment strategies need to be urgently developed. Coptisine a natural alkaloid extracted from rhizoma coptidis which exhibits anticancer activity in various preclinical models, including liver cancer. However, molecular mechanisms underlying effects coptisine remains unclear. We used flow cytometry assess binding 67LR expressed on surface SMMC7721, HepG2, LO2 and H9 cells. Then HepG2 BEL7402...
IR‑783, a near‑infrared heptamethine cyanine dye, has been reported to possess cancer targeting and anticancer effects; Ηowever, the molecular mechanism by which IR‑783 exhibits anti‑breast activity is unclear. In present study, inhibitory effects of on proliferation migration breast cells were investigated. Our results revealed that inhibited MDA‑MB‑231 MCF‑7 cell in dose‑ time‑dependent manner inducing cycle arrest at G0/G1 phase. addition, Transwell assay demonstrated treatment suppressed...
Triple-negative breast cancer (TNBC) has the high degree of malignancy and aggressiveness. There is no targeted therapy drug. Many studies have shown that RBC membrane-coated nanoparticles achieve biological camouflage. In addition, RGD module in iRGD mediates penetration vector across tumor blood vessels to tissue space. Therefore, we developed iRGD-RM-(DOX/MSNs) by preparing MSNs loaded with doxorubicin as core, coating surface iRGD-modified membranes.iRGD-RM-(DOX/MSNs) were fabricated...
Abstract Chiral communications exist in secondary structures of foldamers and copolymers via a network noncovalent interactions within effective intermolecular force (IMF) range. It is not known whether long-range chiral communication exists between macromolecular tertiary such as peptide coiled-coils beyond the IMF distance. Harnessing high sensitivity single-molecule spectroscopy, we investigate interaction covalently linked DNA duplexes by evaluating binding diastereomeric pair three...
Lycorine, a naturally occurring compound extracted from the Amaryllidaceae plant family, has been reported to exhibit antitumour activity in various cancer cell types. In present study, we investigated molecular mechanisms underlying lycorine-induced apoptosis hepatoblastoma HepG2 cells. We found that lycorine induced mitochondria-dependent cells accompanied by mitochondrial permeability transition pore (mPTP) opening, membrane potential (MMP) loss, adenosine triphosphate (ATP) depletion,...
The recent discovery of ultra-high binding affinities in cucurbit[7]uril (CB7)-based host-guest pairs an aqueous environment has rendered CB7 a rather attractive material analytical and biomedical applications. Due to the lack molecular platform that can follow same complex during repetitive mechanical measurements, however, stabilities system have not been revealed, hindering its potential rival widely used conjugation pairs, such as streptavidin-biotin. Here, we assembled DNA template...
ConspectusSingle-molecule mechanochemical sensing (SMMS) is a novel biosensing technique using mechanical force as signal transduction mechanism. In the sensing, chemical binding of an analyte molecule to template converted signals, such tensile force, template. Since can be conveniently monitored by single-molecule tools, optical tweezers, magnetic or Atomic Force Microscopy, often carried out at single level. traditional format ensemble sensitivity achieved via electrical amplifications,...
Src homolog and collagen binding protein 1 (SHCBP1) binds to the SH2 domain of SHC-transforming (SHC1) is involved in midbody organization cytokinesis completion. SHCBP1 has been reported be a cancer driver gene, promoting progression. However, functional role underlying mechanism regulating lung adenocarcinoma (LUAD) cell proliferation migration are incompletely understood. Here, we discovered that overexpressed LUAD tissues associated with poor prognosis. knockdown inhibited by arresting...
The thermal recovery method of steam flooding is one the most common development methods for heavy oil reservoirs. However, after multiple rounds injection development, composition crude and reservoir rock properties have changed greatly, which unfavorable subsequent enhanced recovery. It necessary to study distribution remaining reservoirs, clarify change characteristics components under different conditions. At same time, porosity permeability rocks flooding, its influence on recovery, are...
Abstract Background Non-small cell lung cancer (NSCLC) is the major type of with high morbidity and poor prognosis. Erlotinib, an inhibitor epidermal growth factor receptor (EGFR), has been clinically applied for NSCLC treatment. Nevertheless, erlotinib acquired resistance occurs inevitably in recent years. Methods Through analyzing two microarray datasets, resistant cells (GSE80344) tissue (GSE19188), differentially expressed genes (DEGs) were screened via R language. DEGs then functionally...
Shear force in a homogenizer mechanically unfolds an ensemble set of biomolecular structures.