A5024792869- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- Molecular Sensors and Ion Detection
- Supramolecular Chemistry and Complexes
- Luminescence and Fluorescent Materials
- Porphyrin and Phthalocyanine Chemistry
- DNA and Nucleic Acid Chemistry
- RNA and protein synthesis mechanisms
- Lanthanide and Transition Metal Complexes
- Advanced biosensing and bioanalysis techniques
- Mass Spectrometry Techniques and Applications
- Chemical Synthesis and Analysis
- Polyoxometalates: Synthesis and Applications
- Chemical Thermodynamics and Molecular Structure
- Radioactive element chemistry and processing
- Electron Spin Resonance Studies
- Monoclonal and Polyclonal Antibodies Research
- Chemical Reaction Mechanisms
- Magnetism in coordination complexes
- Organic Chemistry Cycloaddition Reactions
- Bacteriophages and microbial interactions
Science Oxford
2014-2022
University of Oxford
2008-2020
ATDBio (United Kingdom)
2018-2019
Northeast Catholic College
2018
Mansfield University
2012
Daresbury Laboratory
2009
University of Bath
2009
University of Aveiro
2009
Columbia University
1989
The development of solution-based anion receptor molecules which exploit halogen bonding interactions is an emerging area research. This<italic>Feature Article</italic>reviews recent advances have been made in this rapidly developing field, surveying the use iodoperfluoroarene, haloimidazolium and halotriazole/triazolium halogen-bond-donor motifs design describing application mechanically interlocked rotaxane catenane frameworks as host systems.
The synthesis and anion binding properties of novel halogen-bonding (XB) bis-iodotriazole-pyridinium-containing acyclic [2]catenane host systems are described. XB receptor displays selectivity for acetate over halides with enhanced recognition compared to the analogous hydrogen-bonding (HB) receptor. A reversal in halide is observed [2]catenane, comparison receptor, due interlocked host's unique three-dimensional cavity, no oxoanions. Notable association constant values determined...
A tetradentate halogen bond donor foldamer receptor framework is shown to exhibit enhanced anion recognition and chiral discrimination properties.
Abstract A series of heteroditopic receptors containing halogen bond (XB) and unprecedented chalcogen (ChB) donors integrated into a 3,5‐bis‐triazole pyridine structure covalently linked to benzo‐15‐crown‐5 ether motifs exhibit remarkable cooperative recognition halide anions. Multi‐nuclear 1 H, 13 C, 125 Te 19 F NMR, ion pair binding investigations reveal sodium cation–benzo‐crown dramatically enhances the bromide iodide anions, with bonding receptor notably displaying largest enhancement...
The first example of anion templated pseudorotaxane formation between two neutral components in solution and surface assembled monolayers is described.
The design, synthesis, structure, and anion-binding properties of the first indolocarbazole-containing interlocked structure are described. novel [2]rotaxane molecular incorporates a neutral axle component which is encircled by tetracationic macrocycle functionalized with an isophthalamide anion recognition motif. (1)H NMR UV-visible spectroscopies X-ray crystallography demonstrated importance pi-donor-acceptor, CH...pi, electrostatic interactions in assembly pseudorotaxanes between...
Three different chemical cyclisation reactions yield biocompatible cyclic oligonucleotide templates for use in RCA and DNA nanoflower formation.
Abstract Chiral communications exist in secondary structures of foldamers and copolymers via a network noncovalent interactions within effective intermolecular force (IMF) range. It is not known whether long-range chiral communication exists between macromolecular tertiary such as peptide coiled-coils beyond the IMF distance. Harnessing high sensitivity single-molecule spectroscopy, we investigate interaction covalently linked DNA duplexes by evaluating binding diastereomeric pair three...
The surface covalent attachment of indolocarbazole axles enables anion templation to be exploited in the formation pseudorotaxane assemblies via threading neutral isophthalamide macrocycles from solution. selectivity this templating process can monitored by a number spectroscopic methods and shows subtle differences compared same Though fluxional disordered nature ethylene glycol extended axle adlayers prohibits detectable on surface, rotaxane monolayers generated preassociation components...
Neutral heteroditopic [2]rotaxane ion-pair host systems were synthesised<italic>via</italic>a copper(<sc>ii</sc>)-directed metal template strategy and shown to undergo cooperative anion recognition with a co-bound zinc(<sc>ii</sc>) cation.
An active metal template strategy was used to synthesise a neutral indolocarbazole containing [2]rotaxane anion host system. 1H NMR binding investigations reveal that the recognises range of monoanions in acetone-d5 : D2O 95 5 with an unusual interlocked selectivity for acetate and dihydrogenphosphate oxoanions over halides. The rotaxane displays overall sulfate dianion, favouring 2 1 guest stoichiometry at low concentration presence excess sulfate. Fluorescence titration demonstrates is...
The synthesis and anion-recognition properties of two new porphyrin-functionalised [2]rotaxane host molecules are described. rotaxane compounds prepared via a chloride-anion-templated clipping strategy. 1H NMR titration experiments demonstrate that the systems exhibit high binding affinities general selectivities for chloride anions in DMSO-d6 or CDCl3/CD3OD solvent systems. UV-visible fluorescence spectroscopy reveal receptors ineffective as optical anion sensors. However, both shown to be...
The synthesis, structure and anion-recognition properties of a new strapped-porphyrin-containing [2]catenane anion host system are described. assembly the catenane is directed by discrete chloride templation acting in synergy with secondary aromatic donor-acceptor coordinative pyridine-zinc interactions. incorporates three-dimensional, hydrogen-bond-donating anion-binding pocket; solid-state structural analysis catenane⋅chloride complex reveals that encapsulated within catenane's interlocked...
Abstract A series of heteroditopic receptors containing halogen bond (XB) and unprecedented chalcogen (ChB) donors integrated into a 3,5‐bis‐triazole pyridine structure covalently linked to benzo‐15‐crown‐5 ether motifs exhibit remarkable cooperative recognition halide anions. Multi‐nuclear 1 H, 13 C, 125 Te 19 F NMR, ion pair binding investigations reveal sodium cation–benzo‐crown dramatically enhances the bromide iodide anions, with bonding receptor notably displaying largest enhancement...
The surface covalent attachment of fluorescent axles indolocarbazole enables anion templation to be exploited in the formation pseudorotaxane assembliesvia threading neutral isophthalamide macrocycles. In utilising polystyrene beads this process can followed by both magnetic resonance methods and changes axle emission spectrum. analogous assembly templated achieved, with fluoride sulfate, on silica nanoparticles where recognition macrocycle are associated equivalent specific optical change.
Binuclear lanthanide complexes consisting of two binding domains in kinetically stable DO3A pockets linked by a 3-functionalized meta-xylyl bridge form 1:1 adducts with isophthalate and dinicotinate water. The influence buffer, pH ligand structure on the has been investigated.
A new bis-triazacyclononane tris-pyridyl N9 -azacryptand ligand is prepared via a convenient one-pot [2+3] condensation reaction between triazacyclononane and 2,6-bis(bromomethyl) pyridine in the presence of M2 CO3 (M=Li, Na, K). The proton, lithium, sodium, potassium lead(II) complexes are characterised solid state. Preliminary solution-phase competition experiments indicate that cryptand preferentially binds calcium, zinc cations methanol solution.
Strong bidentate ligation between a fluorinated isophthalate and binuclear lanthanide-DO3A species yields new class of (19)F NMR agent with very high nuclear relaxation rates at physiologically-relevant pH.
Abstract Review: 99 refs.