A5069359688- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Vibrio bacteria research studies
- SARS-CoV-2 and COVID-19 Research
- Endoplasmic Reticulum Stress and Disease
- Receptor Mechanisms and Signaling
Academy of Medical Sciences
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
National Center for Clinical Laboratories
2022-2025
Beijing Hospital
2022-2025
ABSTRACT The significance of occult hepatitis B virus (HBV) infection (OBI) has been increasingly recognized while the underlying mechanisms remain incompletely understood. This study aimed to identify high-frequency OBI-related mutations in HBV surface antigen (HBsAg)-negative samples tested by ultrasensitive Lumipulse G HBsAg-Quant assay. OBI were collected from 32 blood establishments across 14 provinces China. assay was performed for re-testing and reclassification OBI. Mutations...
Occult HBV infection (OBI) is a special status during Hepatitis B virus (HBV) infection. The underlying mechanism of its occurrence remains unclear. This study conducted sequencing analysis on 104 OBI plasma samples and 524 HBsAg positive from 29 blood centres, searched for high-frequency mutations in transmembrane domain (TMD) S protein the population. Plasmids with TMD were constructed, vivo vitro functional experiments performed to investigate possible molecular mechanisms occurrence. We...
Occult hepatitis B virus infection (OBI) is an HBsAg negative state in HBV with usually inactive replication. However, there were a minority of individuals positive HBeAg and anti-HBs among OBI blood donors few studies have focused on this unusual serological pattern.2022 plasma that preliminary screened reactive for DNA non-reactive collected from 16 provinces China 2015 to 2018. these samples retested using the Cobas TaqScreen MPX test ARCHITECT Quantitative II assay. Lumipulse HBsAg-HQ...