A5013580236- Effects and risks of endocrine disrupting chemicals
- Nanoparticles: synthesis and applications
- Carcinogens and Genotoxicity Assessment
- Anesthesia and Neurotoxicity Research
- Air Quality and Health Impacts
- Indoor Air Quality and Microbial Exposure
- RNA and protein synthesis mechanisms
- Structural Health Monitoring Techniques
- Cell death mechanisms and regulation
- NF-κB Signaling Pathways
- Microplastics and Plastic Pollution
- Cassava research and cyanide
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Neuroinflammation and Neurodegeneration Mechanisms
- Dye analysis and toxicity
- Ion channel regulation and function
- Environmental Toxicology and Ecotoxicology
- Lung Cancer Research Studies
- Immune Response and Inflammation
- Immunotoxicology and immune responses
- Parasitic infections in humans and animals
- Synthesis and Biological Evaluation
- Chemistry and Chemical Engineering
- Pesticide Residue Analysis and Safety
Tongji University
2024
ShangHai JiAi Genetics & IVF Institute
2024
Qilu Hospital of Shandong University
2022-2024
Hainan Normal University
2024
Stomatology Hospital
2024
Kunming Medical University
2024
Sichuan University
2023-2024
Chengdu University
2024
Hunan Normal University
2015-2023
ShanghaiTech University
2023
Background Asthma is a complex pulmonary inflammatory disease, which characterized by airway hyperresponsiveness, variable airflow obstruction and inflammation in the airways. The majority of asthma allergic asthma, disease caused type I hypersensitivity mediated IgE. Exposures to number environmental chemicals are suspected lead one such pollutant di-(2-ethylheyl) phthalate (DEHP). DEHP manufactured chemical that commonly added plastic products make them flexible. Epidemiological studies...
Formaldehyde (FA), a major industrial chemical and ubiquitous environmental pollutant, has been classified as leukemogen. The causal relationship remains unclear, however, due to limited evidence that FA induces toxicity in bone marrow, the site of leukemia induction, other distal organs. Although induction DNA–protein crosslinks (DPC), hallmark toxicity, was not previously detected marrow FA‐exposed rats monkeys studies published 1980s, our recent showed increased DPC liver, kidney, testes...
Abstract The aggravating effects of zero-dimensional, particle-shaped nanomaterials on allergic asthma have been previously investigated, but similar possible one-dimensional shaped not reported. More importantly, there are no available means to counteract the adverse nanomaterial allow for their safe use. In this study, an ovalbumin (OVA)-sensitized rat model was established investigate whether single walled carbon nanotubes (SWCNTs) aggravate asthma. results showed that SWCNTs in rats...
Dibutyl phthalate (DBP) is mainly taken up by the general population from food intake. To estimate intake of phthalates, determining distribution and accumulation DBP in biological materials was a critical need. In this work, we set two novel approaches with monoclonal antibody specific to determine vivo. The contents liver, kidney, stomach testes were detected immunofluorescence assays indirect competitive ELISA. This data give directly evidence that indicates Double-label assay provides...
BackgroundTumor necrosis factor α-induced protein 1 (TNFAIP1) is frequently downregulated in cancer cell lines and promotes apoptosis. However, its role, clinical significance molecular mechanisms hepatocellular carcinoma (HCC) are unknown.MethodsThe expression of TNFAIP1 HCC tumor tissues was measured by Western blot immunohistochemistry. The effects on proliferation, apoptosis, metastasis, angiogenesis formation were evaluated Cell Counting Kit-8 (CCK8), Terminal deoxynucleotidyl...
The centrosome is the main microtubule-organizing center in animal cells. It comprises of two centrioles and surrounding pericentriolar material. Protein organization at outer layer centriole outward has been studied extensively; however, an overall picture protein architecture core missing. Here we report a direct view Drosophila centriolar proteins ∼50-nm resolution. This reveals Sas6 ring C-terminus, where it overlaps with C-terminus Cep135. ninefold symmetrical pattern Cep135 further...
Background Dibutyl phthalate (DBP) is predominantly used as a plasticizer inplastics to make them flexible. Extensive use of phthalates in both industrial processes and other consumer products has resulted the ubiquitous presence environment. In order better determine level pollution environment evaluate potential adverse effects exposure DBP, immunoassay for DBP was developed. Methodology/Principal Findings A monoclonal antibody specific produced from stable hybridoma cell line generated by...
Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer commonly used in PVC that may leach into the environment, and has been shown to adversely affect health of humans animals.
Di-(2-ethylhexyl) phthalate (DEHP), a commonly used plasticizer, has an adjuvant effect in combination with ovalbumin (OVA). The of DEHP already been verified our previous studies. In this study, to further investigate whether thymic stromal lymphopoietin (TSLP) was involved the DEHP-adjuvant effect, administered through daily gavage exposure route. Mice were sensitized (OVA) trigger allergic responses, and anti-TSLP monoclonal antibody neutralize TSLP. Biomarkers including cytokines...
Background and Objective: Periodontitis is an inflammatory disease that eventually destroys tooth-supporting tissue.Yunnan Baiyao (YNBY), a traditional Chinese medicine compound with haemostatic anti-inflammatory properties has shown therapeutic potential in several diseases.Our previous study revealed YNBY suppressed osteoclast differentiation periodontitis.The purpose of this to investigate the influences on osteoblasts explore its mechanisms.Materials Methods: A rat periodontitis model...
Engineering nanoparticles (ENPs) have been widely used in many areas virtue of its special physical and chemical properties. And ENPs are one the major innovative scientific economic growth things, which may present a variety questions for organisms environment. This paper analyzed ecotoxicological effect nanosized silicon dioxide (Nano-SiO2) normal sized (Nor-SiO2) within 24 hours as bulk counterpart to Daphnia magna with different concentration. To assess aquatic ecosystem safety, EC50...
The compositions and antioxidant capacity were investigated about the by-products (blanching water concentrate (BWC) debitterizing DWC) produced during industrial processing of apricot kernels, to evaluate by-products' potential utilization. results indicate that contain a great number compounds like amygdalin, protein, phenolics, flavonoids. Among them, amygdalin has highest content both in BWC DWC, which is 33.48 ± 0.04 23.89 0.03 (g/100 g dry base weight), respectively. Furthermore, exert...
Metal organic framework based mixed matrix membranes (MOF-MMMs) were synthesized and applied for dispersive membrane extraction (DME) of four neonicotinoid insecticides (nitenpyram, thiacloprid, imidacloprid, acetamiprid) in environmental water, combined with high performance liquid chromatography (HPLC) determination. Several experimental conditions optimized detail, involving dosage percentage MOF, time, sample pH, salinity, type volume eluent, elution time. High sensitivity limits...
Use of biologics has been widely advocated for inflammatory diseases recently. Anti-tumor necrosis factor (TNF)-α antibody therapy is reportedly effective against ocular inflammation. However, side effects TNF-α inhibition have reported, particularly in the form exacerbation infections such as tuberculosis. Paradoxical reactions exacerbated inflammation are also well known. Around 20 million humans infected with human T-cell leukemia virus type 1 (HTLV-1) globally, and this can cause adult...
Abstract Background Cancer stem cells (CSCs) are a specific subpopulation of cancer with the ability self‐renewal, infinite proliferation, multidifferentiation and tumorigenicity, play critical roles in progression treatment resistance. CSCs tightly regulated by tumor microenvironment, such as hypoxia; however, how hypoxia regulates non‐small cell lung (NSCLC) remains unclear. Methods The proportion ALDH hi was examined using Aldefluor assay. Tankyrase inhibitor XAV939 siRNA were used to...
Data fusion is an important issue in bridge health monitoring. Through data fusion, specific unknown responses can be estimated with measured responses. However, existing methods always require a precise finite element model of the or partially target responses, which are hard to realize actual engineering. In this study, we propose novel method. Measured inclinations across multiple cross-sections and accelerations at subset these sections were used estimate remaining sections. Theoretical...