A5090838064- Inflammatory Bowel Disease
- Microscopic Colitis
- Autoimmune and Inflammatory Disorders
- Diagnosis and treatment of tuberculosis
- Inflammatory Biomarkers in Disease Prognosis
- Pancreatitis Pathology and Treatment
- Rice Cultivation and Yield Improvement
- Pediatric Hepatobiliary Diseases and Treatments
- Gut microbiota and health
- Infant Nutrition and Health
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Genetic Mapping and Diversity in Plants and Animals
- Genetics and Plant Breeding
- Neuroblastoma Research and Treatments
- Trace Elements in Health
- Autophagy in Disease and Therapy
- Liver Disease Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Endoplasmic Reticulum Stress and Disease
- Celiac Disease Research and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Photosynthetic Processes and Mechanisms
- interferon and immune responses
Hunan University
2020-2024
The First Affiliated Hospital, Sun Yat-sen University
2020-2024
Sun Yat-sen University
2017-2024
Hunan Rice Research Institute
2023
Ministry of Agriculture and Rural Affairs
2023
Sun Yat-sen University Cancer Center
2017
State Key Laboratory of Oncology in South China
2017
Nanjing Agricultural University
2015
Abstract Improving quality is an essential goal of rice breeding and production. However, not solely determined by genotype, but also influenced the environment. Phenotype plasticity refers to ability a given genotype produce different phenotypes under environmental conditions, which can be representation stability traits. Seven traits 141 hybrid combinations, deriving from test-crossing 7 thermosensitive genic male sterile (TGMS) 25 restorer lines, were evaluated at 5 trial sites with...
We have shown previously that microvesicle (MV)-delivered miR-130b (miR-130b-MV) is able to target PPAR-γ and subsequently reduce the lipid accumulation in vitro. However, vivo effect of on fat deposition glucose homeostasis remains unknown. Three-week-old C57BL/6 mice were fed a high-fat diet for 8 weeks then intravenously injected with MV-packaged scrambled control microRNA (miRNA) or every other day 10 days. Glucose tolerance test was performed body weight, epididymal as well expression...
Abstract Background Fecal lactoferrin (FL) is associated with disease activity and relapse in ulcerative colitis. However, whether FL could early predict long‐term outcomes colitis poorly understood. Methods This post‐hoc analysis included participants who received biologics had available data of concentration at week 4 from the UNIFI PURSUIT trials ( n = 1063). Therapeutic outcomes, including clinical remission, endoscopic improvement histological were evaluated end maintenance therapy. The...
Paclitaxel is not as effective for neuroblastoma most of the front‐line chemotherapeutics due to drug resistance. This study explored regulatory mechanism paclitaxel‐associated autophagy and potential solutions paclitaxel resistance in neuroblastoma. The formation autophagic vesicles was detected by scanning transmission electron microscopy flow cytometry. autophagy‐associated proteins were assessed western blot. Autophagy induced LC 3‐I, 3‐ II , Beclin 1, thioredoxin‐related protein 14 (...
Background Infliximab is effective in inducing and maintaining remission patients with Crohn’s disease (CD), but primary non-response (PNR) occurs 10-30% of cases. We investigated whether serum biomarkers are predicting PNR CD. Methods From January 2016 to April 2020, a total 260 were recruited this prospective retrospective cohort study. Serum samples collected at baseline week 2 infliximab treatment. levels 35 cytokines assessed 18 from the discovery further evaluated 60-patient 1. Then,...
To investigate the characteristics and prognostic value of fecal lactoferrin trajectories in ulcerative colitis (UC).This study used data from UNIFI trial (ClinicalTrials.gov, NCT02407236) included patients who received ustekinumab during induction for trajectory modeling (n = 637). Patients maintenance therapy were 1-year outcome analyses 403). The levels lactoferrin, calprotectin, serum C-reactive protein measured at weeks 0, 2, 4, 8. these biomarkers developed using a latent class growth...
<p indent=0mm>Thermo-sensitive genic male-sterile (TGMS) gene <italic>tms5</italic> is most widely used in the two-line hybrid breeding system China. To develop novel rice thermo-sensitive male sterile lines, we knocked out <italic>TMS5 </italic>genes of six elite <italic>japonica</italic> and four <italic>indica</italic> varieties by using CRISPR/Cas9 editing technology. By analyzing critical sterility-inducing temperature (CIST) newly TGMS it was found that CIST lines ZG75S, CYGS, YG0618S,...
Patients with isolated anastomotic lesions (iAL) are common in postoperative Crohn's disease (CD) and have heterogeneous prognosis.To investigate the prognostic value of neutrophil-to-lymphocyte ratio (NLR) CD patients iAL.A bicenter retrospective cohort study.CD who received ileocolonic resection from 2013 2020 had a modified Rutgeerts score i2a were recruited. NLR was determined within 1 week around initial endoscopy after ileocolectomy. The primary outcome clinical recurrence....
Recent evidence has shown that the complete blood count (CBC) is abnormal in patients with Crohn's disease (CD). We aimed to investigate an effective CBC parameter and explore its impact on activity a large CD cohort.We performed retrospective analysis of established who underwent clinically indicated endoscopy at four tertiary centres China between 2016 2020. Individual variables Simple Endoscopic Score for CD, parameters, C-reactive protein (CRP) levels, erythrocyte sedimentation rate,...
Endoscopic remission is the primary therapeutic target and associated with clinical outcome in Crohn's disease (CD). Non-invasive accurate biomarkers are important monitoring endoscopic frequently. Our study aimed at investigating predictive capacity of prealbumin retinol-binding protein 4 (RBP4) for identifying remission.
Serum amyloid A (SAA) was found to be positively correlated with the activity of Crohn's disease (CD); however, its prognostic value remains uncertain. Here, we examined predictive ability in newly diagnosed CD and explored genetic association.
The possible nonlinear association with therapeutic outcomes in ulcerative colitis may contribute to the inconclusive cutoff values of fecal calprotectin (FC). We aimed explore between FC levels and long-term patients establish a clinically applicable index. included treated vedolizumab or adalimumab from VARSITY (n=661) GEMINI 1 (n=620) studies as discovery validation cohorts, respectively. primary outcome was endoscopic remission at week 52 (Mayo Endoscopic Score 0). Restricted cubic...