A5102726715- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Inflammatory Biomarkers in Disease Prognosis
- Lung Cancer Research Studies
- Cancer, Lipids, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Circular RNAs in diseases
- Cancer Diagnosis and Treatment
- Telomeres, Telomerase, and Senescence
- Venous Thromboembolism Diagnosis and Management
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Head and Neck Cancer Studies
- RNA Research and Splicing
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Glycosylation and Glycoproteins Research
- Single-cell and spatial transcriptomics
Tianjin Medical University Cancer Institute and Hospital
2016-2025
Tianjin Medical University
2011-2014
Huizhou Central People's Hospital
2011
Zen-Noh (Japan)
2001
Abstract Lung adenocarcinoma (LUAD) is a prevalent subtype of lung cancer, yet the contribution purine metabolism (PM) to its pathogenesis remains poorly elucidated. PM, critical component intracellular nucleotide synthesis and energy metabolism, hypothesized exert significant influence on LUAD development. Herein, we employed single‐cell analysis investigate role PM within tumour microenvironment (TME) LUAD. scoring (PMS) across distinct cell types was determined using AUCell, UCell,...
Abstract Immunotherapy has brought significant advancements in the treatment of lung adenocarcinoma (LUAD), but identifying suitable candidates remains challenging. In this study, we investigated tumour cell heterogeneity using extensive single‐cell data and explored impact different cluster abundances on immunotherapy POPLAR OAK cohorts. Notably, found a correlation between CKS1B+ abundance response, as well stemness potential. Leveraging marker genes from cluster, employed machine learning...
Lung adenocarcinoma (LUAD) is a highly heterogeneous disease, posing significant challenges to accurate prognosis prediction. Mitochondria play central role in the energy metabolism of eukaryotic cells and can influence programmed cell death (PCD) mechanisms, which are critical tumorigenesis cancer progression. However, prognostic significance interplay between mitochondrial function PCD LUAD requires further investigation.
Abstract We employed single‐cell analysis techniques, specifically the inferCNV method, to dissect complex progression of lung adenocarcinoma (LUAD) from in situ (AIS) through minimally invasive (MIA) (IAC). This approach enabled identification Cluster 6, which was significantly associated with LUAD progression. Our comprehensive included intercellular interaction, transcription factor regulatory networks, trajectory analysis, and gene set variation (GSVA), leading development signature...
Abstract The progression of lung adenocarcinoma (LUAD) from atypical adenomatous hyperplasia (AAH) to invasive (IAC) involves a complex evolution tumour cell clusters, the mechanisms which remain largely unknown. By integrating single‐cell datasets and using inferCNV, we identified analysed clusters explore their heterogeneity changes in abundance throughout LUAD progression. We applied gene set variation analysis (GSVA), pseudotime analysis, scMetabolism, Cytotrace scores study biological...
Introduction The aim of this study was to investigate the prognostic significance combination preoperative platelet count and neutrophil-lymphocyte ratio (COP-NLR) for predicting postoperative survival patients undergoing complete resection non-small cell lung cancer (NSCLC). Methods COP-NLR calculated on basis data obtained.Patients with both an increased (>30.0×104 mm-3) elevated NLR (>2.3) were assigned a score 2, one or neither as 1 0, respectively. Results A total 1238 NSCLC enrolled in...
Abstract Neuroblastoma (NB) is the most common malignant tumor in infancy and extracranial solid childhood. With improvement of diagnosis treatment, survival rate patients with low-risk intermediate-risk NB can reach up to 90%. In contrast, for high-risk NBs, long-term still <40% because heterogeneity this tumor. The pathogenesis not explicit, therefore it great significance explore mechanism tumorigenesis discover new therapeutic targets NB. Polo-like kinase 4 (PLK4), one polo-like...
Abstract Background The relationship between DNA damage repair (DDR) and cancer is intricately intertwined; however, its specific role in esophageal squamous cell carcinoma (ESCC) remains enigmatic. Methods Employing single‐cell analysis, we delineated the functionality of DDR‐related genes within tumor microenvironment (TME). A diverse array scoring mechanisms, including AUCell, UCell, singscore, ssgsea, AddModuleScore, were harnessed to scrutinize activity across different types....
The aim of the present study was to investigate prognostic value combination preoperative platelet count (PLT) and mean volume (MPV) in patients with primary operable non-small cell lung cancer (NSCLC). We retrospectively analysed data from 546 NSCLC who underwent complete resection at our institution 2006 2010. Patients' clinical characteristics laboratory test initial diagnosis were collected. Both PLT MPV (COP-MPV) calculated on basis obtained using recommended cut-off values 300 × 109...
The purpose of the present study was to characterize prevalence, associated factors, and construct a nomogram for predicting bone metastasis (BM) with different histological types lung cancer.This descriptive that basing on invasive cancer patients diagnosed between 2010 2014 in Surveillance, Epidemiology, End Results program. A total 125,652 adult were retrieved. Logistic regression analysis conducted investigate homogeneous heterogeneous factors BM occurrence. Nomogram constructed predict...
Background Lung adenocarcinoma (LUAD) presents significant challenges in prognosis and treatment efficacy evaluation. While post-translational modifications are known to influence tumor progression, their prognostic value LUAD remains largely unexplored. Methods We developed a modification learning signature (PTMLS) using machine techniques, analyzing data from 1231 patients across seven global cohorts. The signature’s predicting immunotherapy response was evaluated 12 cohorts spanning...
Lipid metabolic disorders are emerging as a recognized influencing factors of lung adenocarcinoma (LUAD). This study aims to investigate the influence lipid metabolism-related genes (LMRGs) on diagnosis and treatment LUAD identify significant biomarkers. DESeq2 robust rank aggregation (RRA) analyses were employed determine differential expression LMRGs from TCGA-LUAD five GEO datasets. Mendelian randomization (MR) was conducted utilizing protein quantitative trait loci (pQTLs) in deCODE,...
The SARI (suppressor of AP-1, regulated by IFN) gene, which is also called BATF2, associated with the risk several kinds cancer, and loss expression frequently detected in aggressive metastatic cancer. However, functional role lung adenocarcinoma remains unknown. We have shown that initiates epithelial-mesenchymal transition (EMT), visualized repression E-cadherin up-regulation vimentin cell lines clinical specimens. Using a human xenograft-mouse model, we observed knocking down endogenous...
As shortened telomeres inhibit tumor formation and prolong life span in a KrasG12D mouse lung cancer model, we investigated the implications of telomerase Kras-mutant NSCLC. We found that Kras mutations increased TERT (telomerase reverse transcriptase) mRNA expression activity telomere length both immortalized bronchial epithelial cells (BEAS-2B) adenocarcinoma (Calu-3). MEK inhibition led to reduced activity. Furthermore, inhibitor BIBR1532 inhibited mutant Kras-induced long-term...
Claudins are essential for the formation and maintenance of tight junctions (TJ). The altered expression claudin proteins has been described in a variety malignancies. However, alteration these lung adenocarcinoma (ADC) poorly understood. Therefore, we report, based on protein analysis total 275 patient samples, that claudin-3 (CLDN3) is significantly increased ADC tissues associated with cancer progression, correlating poor survival patients (p=0.041&0.029). More importantly, forcing CLDN3...
To assess the potential prognostic value of albumin to alkaline phosphatase ratio (AAPR) in patients with non-small cell lung cancer (NSCLC) after surgery.The log-rank and Kaplan-Meier analyses were performed detect differences survival levels between different groups. A model Cox proportional hazards was used perform univariate multivariate analyses. Comparisons receiver operating characteristic (ROC) curves likelihood test (LRT) also utilized compare abilities systems for overall (OS)...
The ligand/receptor pair C‑C motif chemokine ligand 20 (CCL20)/C‑C receptor 6 (CCR6) is considered to be highly activated in lung cancer and significantly accelerates progression through activation of ERK signaling. In addition, it has been shown that long non‑coding RNA‑u50535 (lncRNA‑u50535) upregulates CCL20 expression facilitates colorectal (CRC). However, the effects lncRNA‑u50535 whether regulates CCL20/CCR6/ERK signaling remain ill‑defined. Therefore, aim present study was investigate...
Introduction Targeting activating oncogenic driver mutations in lung adenocarcinoma has led to prolonged survival patients harboring these specific genetic alterations. The prognostic value of not yet been elucidated. prevalence recently uncovered non-coding somatic mutation promoter region TERT gene is also be validated cancer. purpose this study show the prevalence, association with clinicalpathological features and factors. Methods In a cohort non-small cell cancer (NSCLC) (n = 174,...
: Immunotherapy is one of the most effective treatments for patients with advanced lung cancer. In many non-small cell cancer (NSCLC) cases, tumor centrally located. For such patients, sleeve lobectomy has been considered as a more therapeutic option compared pneumonectomy, achieving better long-term survival and quality life no increase in morbidity or mortality. Until now, there have studies regarding efficacy safety neo-adjuvant chemo-immunotherapy prior to From January 2019 through...
Cripto-1 can promote tumourigenesis and may be a potential prognostic biomarker in several malignancies, yet little is known about this protein lung adenocarcinoma (LAC). The aim of study was to evaluate the value cripto-1 expression cohort patients with LAC. Tumours from 290 pathologically confirmed LAC were used for an immunohistochemical analysis expression. correlation between clinicopathological parameters patients, EGFR-TKI sensitivity analysed. Significant associations pT status, pN...
Background Tobacco use is responsible for approximately 80–90% of non‐small cell lung cancer cases. A large evidence base has shown that the ERBB pathway associated with occurrence cancer. However, mechanisms how smoking activates have yet to be explained. We hypothesized microRNAs may induce activity during process carcinogenesis. Methods analyzed microRNA array data from Gene Expression Omnibus and Kyoto Encyclopedia Genes Genomes determine any associations between genes in three groups...