A5002155526- Gut microbiota and health
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Ruminant Nutrition and Digestive Physiology
- Meat and Animal Product Quality
- Pancreatic function and diabetes
- Congenital Diaphragmatic Hernia Studies
- Sirtuins and Resveratrol in Medicine
- Pleural and Pulmonary Diseases
- Probiotics and Fermented Foods
- Lymphatic Disorders and Treatments
- Calpain Protease Function and Regulation
- Electron Spin Resonance Studies
- Solar Radiation and Photovoltaics
- Forensic Toxicology and Drug Analysis
- Chemotherapy-induced cardiotoxicity and mitigation
- Peroxisome Proliferator-Activated Receptors
- Muscle metabolism and nutrition
- Clostridium difficile and Clostridium perfringens research
- RNA and protein synthesis mechanisms
- Berry genetics and cultivation research
- Metabolomics and Mass Spectrometry Studies
- Antibiotic Resistance in Bacteria
- Muscle Physiology and Disorders
- Fermentation and Sensory Analysis
Lanzhou Institute of Husbandry and Pharmaceutical Sciences
2021-2025
Chinese Academy of Agricultural Sciences
2021-2025
Hubei University of Science and Technology
2023
State Key Laboratory of Respiratory Disease
2023
Guangzhou Medical University
2023
Gansu Agricultural University
2016-2022
University of New Hampshire
2015
The intestinal barrier is vital for preventing inflammatory bowel disease (IBD). objectives of this study were to assess whether the Lactobacillus rhamnosus CY12 could alleviate oxidative stress, inflammation, and disruption tight junction (TJ) functions induced by lipopolysaccharide (LPS), therefore explore potential underlying molecular mechanisms. Our results showed that LPS-induced Cancer coli-2 (Caco-2) cells significantly increased levels reactive oxygen species (ROS), lactate...
Chylothorax is a rare but potentially life-threatening complication after esophageal cancer resection. This study aims to investigate the impact of strategy combining preoperative three-dimensional (3D) reconstruction contrast-enhanced chest CT with olive oil ingestion on incidence chylothorax following We retrospectively analyzed clinical data 357 patients who underwent resection in Department Thoracic Surgery at Gansu Provincial People's Hospital from January 2019 June 2024. Among them,...
The effects of different dietary energy levels on the ruminal bacterial population, selected meat quality indices, and their relationship in yak longissimus thoracis (LT) muscle were assessed this study. A total 15 castrated yaks randomly assigned to three groups with low- (NEg: 5.5 MJ/Kg, LE), medium- 6.2 ME), high- 6.9 HE) occurred cold season (March May). All from each treatment group humanely slaughtered sampled day completion feeding treatment. results showed that water content crude...
Gut microbiome and heredity are two important factors affecting the intramuscular fat (IMF) of cattle, excluding age, sex, nutrition. This study aimed at deciphering these differences by analyzing gut differentially expressed genes (DEGs) in Angus Chinese Simmental cattle. Feces longissimus dorsi were collected from groups animals (n = 20/group) for multiomics analysis. holds a significantly higher diversity than Simmental, relative abundance Roseburia, Prevotella, Coprococcus, etc., was...
Abstract Background Rumen microbes play an important role in ruminant energy supply and animal performance. Previous studies showed that the rumen microbiome of Mongolian cattle has adapted to degrade rough forage provide sufficient tolerate harsh desert ecological conditions. However, little is known about succession different developmental stages post-weaning cattle. Methods Here, we examined microbial composition structure 15 at three i.e., 5 months (RM05), 18 (RM18) and, 36 (RM36) by...
Oral ingestion of probiotics is a promising approach to relieving inflammatory disease through regulating the gut microbiota. A newly discovered strain, Lactobacillus rhamnosus CY12 (LCY12), obtained from cattle-yak milk, displayed numerous probiotic properties. These included enhanced viability in low pH and bile environments, adhesion capabilities, potent antimicrobial effects. The research aimed explore beneficial impacts novel LCY12 strain on colitis mice induced by dextran sulfate...
Streptococcus dysgalactiae is a major pathogen in bovine mastitis. The purpose of this study was to survey the prevalence, antimicrobial resistance, as well spread resistance and virulence-associated gene S. dysgalactiae.A total 60 strains were obtained from 830 milk samples Holstein cows with clinical Antimicrobial examined by disk diffusion method. virulence genes investigated PCR, agarose gel electrophoresis 16S rRNA sequencing.All isolates resistant tetracycline showed high level...
This study investigated the activity of adenosine monophosphate-activated protein kinase (AMPK), glycolysis, and meat quality index in three altitude bovines during postmortem aging process. Local cattle (altitude:1,500 m), Gannan yak (3,000 Yushu (4,500 m) Longissimus Dorsi (LD) muscle were used. Results indicated that CaCl2 significantly increased AMPK by increasing calcium-regulated (CaMKKβ) activity. Besides, activation enhanced lactate dehydrogenase (LDH) Ca2+-ATPase accelerated rate...
To explore the postmortem physiological mechanism of muscle, activity adenosine monophosphate activated protein kinase (AMPK) as well its role in energy metabolism yaks were studied. In this experiment, we injected 5-amino-1-beta-d-furanonyl imidazole-4-formamide (AICAR), a specific activator AMPK, and STO-609 to observe changes glycolysis, metabolism, AMPK activity, gene expression (PRKA1 PRKA2) during maturation. The results showed that AICAR could increase PRKKA1 PRKAA2 genes, activate...
AMPK can activate nicotinamide phosphoribosyltransferase (NAMPT), increasing the ratio of oxidized adenine dinucleotide (NAD+)/reduced (NADH) ratio, leading to activation energy receptor SIRT1. This pathway is known as AMPK/SIRT1 signaling pathway. SIRT1 deacetylates and LKB1, which activated by phosphorylation (Thr172) inhibited phosphorylase-mediated dephosphorylation AMPK. At same time, increased AMP/ATP NAD+/NADH ratios lead each other forming a positive feedback loop, strengthen...
This study aimed to investigate the prevalence and genetic characterization of Serratia marcescens isolates from clinical bovine mastitis in Ningxia Hui Autonomous Region China.S. was identified by polymerase-chain reaction 16S rRNA gene sequencing. Antimicrobial susceptibility tested disk diffusion method. Genes resistance virulence were determined PCR.Overall, S. confirmed 32 2897 (1.1%) milk samples. These showed high cefazolin (30/32, 93.8%) chloramphenicol (28/32, 87.5%). A 12.5% (4/32)...
To identify differentially expressed proteins associated with energy metabolism and tenderness during the postmortem aging of yak longissimus lumborum muscle samples, we collected tissue samples from yaks raised at different altitudes. At 12 h post-slaughter, identified 290 (DEPs) in these whereas 436 such DEPs were detected after 72 h. Identified clustered into four main functional categories: cell structural proteins, glycogen metabolic reserve cellular polysaccharide proteins. Further...
<title>Abstract</title> Background Chylothorax, a rare yet potentially fatal complication, may arise following esophageal cancer resection. The objective of this study is to assess the effectiveness combined approach involving enhanced chest CT with three-dimensional(3D) reconstruction and preoperative olive oil administration in mitigating risk chylothorax after surgery. Methods A retrospective analysis was performed on clinical records 357 patients who underwent resection at Department...
Inflammatory bowel disease (IBD) is a serious global public health concern. Although the pathogenesis of currently unknown, it has been reported to be associated with both intestinal microbiota and inflammatory mediators. There evidence suggesting that feces Plateau pika useful for treating gastrointestinal injuries pain. fecal transplantation highly efficacious intervention IBD prevention, however, potential transfer pathogenic microbes or toxic substances potentially hazardous....
Abstract To explore the postmortem physiological mechanism of muscle, activity adenosine monophosphate activated protein kinase (AMPK) as well its role in energy metabolism yaks were studied. In this experiment, we injected 5-amino-1-beta-d-furanonyl imidazole-4-formamide (AICAR), a specific activator AMPK, and AMPK inhibitor STO-609, to observe changes glycolysis, metabolism, gene expression (PRKA1 PRKA2) during maturation. The results showed that AICAR could increase PRKKA1 PRKAA2 genes,...