A5101744498- Alzheimer's disease research and treatments
- Pancreatic function and diabetes
- Tryptophan and brain disorders
- Biotin and Related Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Berberine and alkaloids research
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Neuroscience and Neuropharmacology Research
- Click Chemistry and Applications
- Metabolism, Diabetes, and Cancer
- Mitochondrial Function and Pathology
- Inflammasome and immune disorders
- Autophagy in Disease and Therapy
- Cancer, Lipids, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Genomics, phytochemicals, and oxidative stress
- Nuclear Receptors and Signaling
- Neuropeptides and Animal Physiology
- Natural Antidiabetic Agents Studies
- Phytochemistry and Biological Activities
- Neurological Disease Mechanisms and Treatments
- Diet, Metabolism, and Disease
- Diabetes Treatment and Management
- Phytochemicals and Antioxidant Activities
Hubei University of Science and Technology
2014-2025
Nanchang University
2024
First Affiliated Hospital of Jiangxi Medical College
2024
Lanzhou University
2024
Lanzhou University Second Hospital
2024
Guangxi University of Chinese Medicine
2020-2024
Guangxi University
2020
Huazhong University of Science and Technology
2017-2018
Central South University
2014-2016
Third Xiangya Hospital
2014-2016
Background: One of the typical symptoms diabetes mellitus patients was memory impairment, which followed by gradual cognitive deterioration and for there is no efficient treatment. The anti-diabetic incretin hormones glucose-dependent insulinotropic polypeptide (GIP) glucagon-like peptide-1 (GLP-1) were demonstrated to have highly neuroprotective benefits in animal models AD. We wanted find out how GLP-1/GIP dual agonist tirzepatide affected diabetes's impairment spatial learning memory....
Purpose. Type 2 diabetes mellitus is considered as one of the risk factors for cognitive impairment. DPP4 inhibitors are effective drugs treatment type mellitus. However, relationship between and dysfunction remains unclear. Therefore, we used a meta-analysis to determine association impairment in Methods. We systematically searched PubMed, CNKI, Cochrane Library at time establishment, 2022, then made inclusion criteria screened strategies identify studies with more precise correlations....
Kainic acid (KA)-induced neuronal death is linked to mitochondrial dysfunction and ER stress. Melatonin known protect hippocampal neurons from KA-induced apoptosis, but the exact mechanisms underlying melatonin protective effects against mitochondria disorder stress remain uncertain. In this study, we investigated sheltering roles of during apoptosis by focusing on mediated signal pathways. KA causes dynamic through calpain activation, leading apoptosis. Ca2+ chelator BAPTA-AM inhibitor...
Background: Cognitive impairment caused by diabetes has been recognized. Berberine is well known for its resistance to peripheral lesions, but it rarely used the treatment of spatial learning and memory diabetes. This study explored mechanism berberine alleviate cognitive via cholinergic anti-inflammatory insulin signaling pathways. Methods: Morris water maze was appraise memory. Positron-emission tomography (PET) imaging adopted detect transport glucose, blood/cerebrospinal fluid (CSF)...
Alzheimer’s disease (AD) is tightly related to endoplasmic reticulum stress (ER stress), which aggravates two dominant pathological manifestations of AD: senile plaques and neurofibrillary tangles. Berberine widely applied in the clinical treatment many diseases reported have anti-AD effects. In present study, berberine was shown ameliorate ER cognitive impairment APP/PS1 mice. We found plays a role as central hub for signal transduction, evidenced by hyperactivation glycogen synthase kinase...
Kainic acid (KA) exposure causes neuronal degeneration featured by Alzheimer-like tau hyperphosphorylation and memory deficits. Melatonin (Mel) is known to protect hippocampal neurons against KA-induced damage. However, the underlying mechanisms remain elusive. In current study, we investigated protective effect of melatonin on focusing endoplasmic reticulum (ER) stress-mediated signaling pathways. By using primary mouse brain, showed that KA treatment specifically induced ER stress...
Lysimachia christinae Hance is a traditional Chinese medicine with diuretic, detumescent, and detoxifying effects. Our aimed to optimize the extraction protocol maximize yield of flavonoids from Hance, evaluate pharmacological activities four fractions, namely, petroleum ether (PE), ethyl acetate (EA), n-butanol (NB), aqueous (AQ) ethanolic extract Hance.The flavonoid monomers in crude were characterized via high performance liquid chromatography (HPLC), used as markers for quality control...
Emerging research suggests a potential association of progression Alzheimer's disease (AD) with alterations in synaptic currents and mitochondrial dynamics. However, the specific associations between these pathological changes remain unclear. In this study, we utilized Aβ42-induced AD rats primary neural cells as vivo vitro models. The investigations included behavioural tests, brain magnetic resonance imaging (MRI), liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) analysis, Nissl...
Background: Diabetic nephropathy (DN) is the leading cause of impaired renal function. The purpose this study was to investigate effects Mogroside IIIE (MG IIIE), a cucurbitane-type compound isolated from Siraitia grosvenorii , in high glucose (HG)-induced podocytes and possible mechanisms. Methods: MPC-5 cells were cultured under normal or HG conditions. After treatment with MG IIIE, cell viability examined using counting kit-8 assay. contents inflammatory factors oxidative stress-related...