A5040778758- Connexins and lens biology
- Intraocular Surgery and Lenses
- Yersinia bacterium, plague, ectoparasites research
- Heat shock proteins research
- Flavonoids in Medical Research
- Glaucoma and retinal disorders
- Ocular Diseases and Behçet’s Syndrome
- Pharmacological Effects of Natural Compounds
- Spaceflight effects on biology
- Retinal Diseases and Treatments
- Ocular Disorders and Treatments
- Retinal and Macular Surgery
- Retinal Development and Disorders
- Corneal surgery and disorders
- Forensic and Genetic Research
- Neurological Disease Mechanisms and Treatments
- Mycobacterium research and diagnosis
- Sarcoidosis and Beryllium Toxicity Research
- Identification and Quantification in Food
- Phagocytosis and Immune Regulation
- Kruppel-like factors research
- Traditional Chinese Medicine Analysis
- Nephrotoxicity and Medicinal Plants
- Immunotherapy and Immune Responses
- High Altitude and Hypoxia
Beijing Anzhen Hospital
2020-2024
Capital Medical University
2010-2024
Xiamen University
2024
Chengdu University of Traditional Chinese Medicine
2021-2022
Shandong First Medical University
2020-2021
Jinan City People's Hospital
2020
Beijing Tongren Hospital
2007-2019
Abstract The ability of some animals to rapidly change their colors can greatly improve chances escaping predators or hunting prey. A classic example is cephalopods, which shift through a wide range colors. This based on the synergetic effect pigmentary and structural exhibited by own two categories color‐changing cells: supernatant chromatophores offer various lower iridophores leucophores reflect different adjusting periodicities. Here, mechanochromic liquid crystalline elastomer with...
Diabetic retinopathy (DR) is a leading cause of irreversible blindness globally. Qidengmingmu Capsule (QC) Chinese patent medicine used to treat DR, but the molecular mechanism treatment remains unknown. In this study, we identified and validated potential mechanisms involved in DR with QC via network pharmacology docking methods. The results Ingredient-DR Target Network showed that 134 common targets 20 active ingredients were involved. According enrichment analysis, 2307 biological...
Hereditary cataract is a phenotypically and genetically heterogeneous lens disease that responsible for significant proportion of the visual impairment blindness occurs in children. In five-generation Chinese family with autosomal dominant inherited congenital cataract, clinical examination showed three phenotypes: punctuate, nuclear, total cataracts. Linkage analysis was performed positive two-point LOD scores (with maximum 4.43 4.27 at theta=0) were obtained markers D21S1411 D21S1890 on...
Congenital cataract is a highly heterogeneous disorder at both the genetic and phenotypic levels. This study was conducted to identify disease locus for autosomal dominant congenital cataracts in four generation Chinese family.Family history clinical data were recorded. All members genotyped with microsatellite markers which are close known loci cataracts. Two-point Lod scores obtained using MLINK of LINKAGE program package (ver 5.1). Candidate genes amplified by polymerase chain reaction...
Purpose: To identify the genetic defect in a three-generation Chinese family with congenital cataracts.Methods: The phenotype of cataract was recruited. Detailed history and clinical data were recorded. Candidate genes sequencing performed to screen out disease-causing mutation. Bioinformatics analysis predict function mutant gene.Results: identified as nuclear cataract. Direct revealed c.161 G > T transversion exon 1 crystallin alpha-A (CRYAA). This mutation co-segregated all affected...
Purpose: To identify the genetic defect in a four-generation Chinese family with autosomal dominant congenital nuclear cataract.
Accumulating evidence suggests the critical role of autophagy in pathogenesis diabetic retinopathy (DR). In current study, we aim to identify genes involved DR via microarray analyses. Gene microarrays were performed differentially expressed lncRNAs/mRNAs between normal and retinas. Ontology Kyoto Encyclopedia Genes Genomes analyses lncRNA-coexpressed mRNAs used determine related pathological pathways biological modules. Real-time polymerase chain reactions (PCR) conducted validate A total...
We sought to identify the genetic defect in a four-generation Chinese family with autosomal dominant congenital nuclear cataracts, examine clinical features detail and demonstrate functional analysis of candidate gene family.Family history data were recorded. Clinical ophthalmological examinations performed on affected unaffected members. All members genotyped microsatellite markers at loci considered be associated cataracts. Two-point LOD scores calculated using LINKAGE program package...
Congenital cataract is a clinically and genetically heterogeneous group of eye disorders that causes visual impairment childhood blindness. The purpose this study was to identify the genetic defect associated with autosomal dominant congenital perinuclear in Chinese family. A detailed family history clinical data were recorded, candidate gene sequencing performed screen for mutation-causing disease our study. Direct revealed c.601G>A (p.E201K) transversion exon 2 GJA8. This mutation...
MicroRNAs (miRNAs) negatively regulate the expression of target genes by binding to 'seed sequences' in 3'‑untranslated region (3'‑UTR) mRNA transcripts, and variants within or nearby may compromise enhance miRNA/mRNA interaction leading either 'loss‑of‑function' 'gain‑of‑function' effects. Cataracts are cause blindness worldwide characterized progressive aggregation precipitation lens proteins, development age‑related cataracts is associated with dysregulated cellular activities epithelial...
Abstract The injury of vascular endothelial cells is a crucial factor in the development diabetic retinopathy (DR). PDLIM1 (a member PDZ and LIM protein family) has been reported to exert an essential function diseases. This study aimed elucidate role on retinal DR. Immunofluorescence staining was used localize expression mouse retina. In some tumor diseases, play key regulating Wnt pathway. However, no in-depth reports have found Retinal capillary (RCECs) were treated with high-glucose...
One prominent pathological feature of congenital aniridia is hypoplasia the iris, often accompanied by other eye abnormalities. The objective this study to identify gene mutations responsible for autosomal dominance in a Chinese family with aniridia, progressive cataracts and mental retardation.A total 11 members, including 6 affected 5 unaffected individuals were recruited. Whole exome sequencing was performed on proband Sanger applied causal mutation members control samples.A heterozygous...