A5046898426- interferon and immune responses
- Immune Response and Inflammation
- Aquaculture disease management and microbiota
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- NF-κB Signaling Pathways
- Receptor Mechanisms and Signaling
- Metabolism, Diabetes, and Cancer
- Aquaculture Nutrition and Growth
- Neuroscience and Neuropharmacology Research
- Protein Kinase Regulation and GTPase Signaling
- Axon Guidance and Neuronal Signaling
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Mosquito-borne diseases and control
- Peroxisome Proliferator-Activated Receptors
- Redox biology and oxidative stress
- Ion channel regulation and function
- Electromagnetic Fields and Biological Effects
- Insect-Plant Interactions and Control
- Insect and Pesticide Research
- Virus-based gene therapy research
- Neurogenesis and neuroplasticity mechanisms
- Tryptophan and brain disorders
- Cancer Mechanisms and Therapy
Huazhong Agricultural University
2013-2022
Chinese Academy of Agricultural Sciences
2022
Academy of Military Medical Sciences
2019-2021
Hubei University of Medicine
2016
Taihe Hospital
2016
Tsinghua University
2005-2015
Yale University
2013-2014
Jilin University
2014
Wuhan University
2009-2013
Jilin Medical University
2011
Ubiquitination and deubiquitination have emerged as critical post-translational regulatory mechanisms for activation or attenuation of the virus-triggered type I interferon (IFN) 2The abbreviations used are: IFNinterferonTLRToll-like receptorVSVvesicular stomatitis virusRNAiRNA interferenceSeVSendai virus.2The virus. induction pathways. In this study, we identified two deubiquitinating enzymes, OTUB1 OTUB2, negative regulators IFN induction. Overexpression OTUB2 inhibited virus-induced IRF3...
Innate immune recognition is critical for the induction of adaptive responses; however underlying mechanisms remain incompletely understood. In this study, we demonstrate that T cell-specific deletion IL-6 receptor α chain (IL-6Rα) results in impaired Th1 and Th17 cell responses vivo, a defect Tfh function. Depletion Tregs these mice rescued but not response. Our data suggest signaling effector cells required to overcome Treg-mediated suppression vivo. We show cooperates with IL-1β block...
Ag receptor engagement triggers lymphocyte activation and proliferation by activating several transcription factors including NF-κB. Caspase recruitment domain (CARD) containing membrane-associated guanylate kinase (MAGUK) protein 1 (CARMA1) is an essential adaptor that links receptors to NF-κB activation. Here, we identify stress-induced-phosphoprotein homology U-box (STUB1) as a CARMA1-associated protein. STUB1 constitutively interacted with CARMA1, the interaction was intensified TCR...
As a fierce pathogen, spring viremia of carp virus (SVCV) can cause high mortality in the common carp, and its glycoprotein (G protein) is component viral structure on surface virion, which crucial life cycle. This report adopted tandem affinity purification (TAP), mass spectrometry analysis (LC-MS/MS), immunoprecipitation, confocal microscopy assays to identify Heat shock cognate protein 70 (HSC70) as an interaction partner SVCV G protein. It was found that HSC70 overexpression dramatically...
Neuronal network reconstruction is a pivotal determinant for functional recovery after spinal cord injury (SCI), the process of which includes synaptogenesis. Slit2 protein has been identified as key regulator axon regeneration and synapse formation in vertebrate. Meanwhile, RhoA converging cascade inhibitory molecules that interrupt synaptic plasticity SCI. In present study, we investigated interaction among Slit2, Robo1, potential roles pathological We showed was decreased, whereas Robo1...
High-power microwaves (HPMs) have been reported to hazardous effects on multiple human and animal organs. However, the biological of 1.5-GHz HPMs reproductive system are not clear. Here, we studied 1.5 -GHz HPM whole-body exposure pathological structure testicles changes in spermatozoa mobility. C57BL/6 mice groups L, M, H were exposed fields for two 15-min intervals at average specific absorption rates 3, 6, 12 W/Kg, respectively. The spermatozoa, as well serum testosterone sperm motility...
This study was designed to investigate effects of dietary Chlorella meal (CM) additive on growth performance, immune responses and appetite regulation juvenile crucian carp Carassius auratus (initial body weight: 1.27 ± 0.03 g). Four experimental diets were formulated contain 0% (CM0), 1% (CM1), 2% (CM2) 4% (CM4), respectively. Each diet randomly assigned triplicate groups with 40 fish per fibreglass tank for 8 weeks. Weight gain rate, specific rate feed intake increased increasing CM...
Thousands of people die each year from Japanese encephalitis (JE) caused by the virus (JEV), probably due to exacerbation inflammatory response that impairs course disease. Microglia are mononuclear phagocytic cells located within parenchyma central nervous system; these play a key role in innate immune against JEV infections. However, involvement toll-like receptor 2 (TLR2) during early stages infection BV2 remains. Here, we evaluated protein profiles and determined TLR2 JEV-infected cells....
T-cell receptor (TCR)-induced activation is a critical event in adaptive immune responses. The engagement of TCR complex by antigen along with the costimulatory receptors trigger cascade intracellular signaling, which caspase recruitment domain-containing membrane-associated guanylate kinase 1 (CARMA1) crucial scaffold protein. Upon stimulation, CARMA1 recruits downstream molecules including B-cell CLL/lymphoma 10 (Bcl10), mucosa-associated lymphoid tissue lymphoma translocation gene...
Abstract: Drugs that influence tubulin function were used to investigate the role of microtubules in hexose uptake by C6 glioma cells. In cells, colchicine and vinblastine (which inhibit polymerization) inhibited radioactive [ 3 H]2‐deoxy‐D‐glucose about 30%. Paclitaxel promotes stimulated 25%. To further demonstrate play a uptake, cells transfected with GLUT1 cDNA then challenged 100 nM paclitaxel. GLUT1‐ paclitaxel 2‐deoxy‐D‐glucose 35%. study agonist‐stimulated effect on...
THE mechanism of ethanol inhibition glucose uptake was investigated using C6 glioma cells. Basal [3H]2-deoxy-D-glucose (2DG) by cells inhibited in a concentration-dependent manner. Fifty, 75 and 100 mM significantly basal 2DG 12, 20 23%, respectively (p < 0.05). Carbachol (an agonist acting via G protein-coupled receptors) stimulated the 26% In presence ethanol, ability carbachol to stimulate abolished. contrast, did not inhibit insulin uptake. These results suggest that inhibits selectively...
To understand the mechanism of ethanol action on G protein-mediated signal transduction pathway, effect muscarinic receptor-G protein coupling in rat cerebral cortex was examined. Acetylcholine (ACh)-stimulated GTPase activity used as an index coupling. ACh stimulation time- and concentration-dependent, atropine-sensitive. Rats injected with (3 g/kg body weight) were sacrificed after 4 hr, cortices removed. The ability to stimulate similar cortical cell membranes obtained from control...
THE role of G proteins in glucose uptake was investigated using C6 glioma cells. Carbachol (an agonist acting via protein coupled receptors) and 5′-guanylylimido diphosphate (Gpp(NH)p; a nonhydrolysable guanine nucleotide analog which bypasses the receptors directly activates proteins) stimulated [3H]2-deoxy-D-glucose (2DG) by cells, suggesting that hexose is protein-mediated process. To identify involved effect carbachol on 2DG examined presence pertussis toxin. Pertussis toxin treatment...