A5101479604- Immune cells in cancer
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Pancreatitis Pathology and Treatment
- Ubiquitin and proteasome pathways
- Inflammation biomarkers and pathways
- Nutrition and Health in Aging
- Phagocytosis and Immune Regulation
- Eosinophilic Disorders and Syndromes
- Digestive system and related health
- interferon and immune responses
- Eosinophilic Esophagitis
- Macrophage Migration Inhibitory Factor
- IL-33, ST2, and ILC Pathways
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Clinical Nutrition and Gastroenterology
Shanghai Jiao Tong University
2014-2017
Texas Tech University
1997
Macrophages affect the magnitude and duration of inflammatory response in a functionally heterogeneous manner. The phenotype macrophages is maintained through reversible homeostatic mechanism. A number determinants that modulate macrophage plasticity have been identified, although precise mechanisms are not fully understood. In this study, we report stimulation isolated human blood monocytes mouse bone marrow-derived with serum amyloid (SAA), major acute-phase protein, leads to induced...
Interleukin‐33 (IL‐33), an IL‐1 family cytokine and nuclear alarmin, is constitutively expressed in epithelial barrier tissues human blood vessels. However, little known about the induced expression of IL‐33 monocytes macrophages, which are major cytokine‐producing cells innate immune system. Here, we report induction IL33 both mouse macrophages from C57BL/6 mice by acute‐phase protein serum amyloid A (SAA). SAA‐induced transcriptional activation Il33 gene, resulting accumulation protein....
Lung infections are major causes of acute lung injury (ALI), with limited effective treatment available. Tumor necrosis factor receptor-associated 6 (TRAF6) is an essential adaptor regulating Toll-like receptors (TLRs). We recently identified Cullin-5 (Cul-5) as a prominent component in the regulation TRAF6 polyubiquitination, but its physiological significance ALI has not been explored. In this study, we investigated potential role Cul-5 using mice receiving intratracheal instillation LPS....
Abstract TNFR-associated factor (TRAF)6 integrates signals from multiple cell surface receptors for the activation of NF-κB. However, mechanism underlying LPS-induced TRAF6 signaling remains unclear. We report that cullin-5 (Cul-5), a cullin family scaffold protein, binds to and promotes polyubiquitination at Lys63 in response LPS stimulation. A direct interaction between C-terminal domain Cul-5 TRAF-C facilitates TRAF6. Hemizygous knockout is associated with improved survival mice following...