A5066979927- Reproductive Biology and Fertility
- Pluripotent Stem Cells Research
- Renal and related cancers
- Animal Genetics and Reproduction
- Plant Stress Responses and Tolerance
- Hippo pathway signaling and YAP/TAZ
- Reproductive System and Pregnancy
- Plant nutrient uptake and metabolism
- Plant responses to water stress
- Collembola Taxonomy and Ecology Studies
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- Nanocluster Synthesis and Applications
- Cannabis and Cannabinoid Research
- Immune cells in cancer
- Protist diversity and phylogeny
- Metabolism, Diabetes, and Cancer
- Glycosylation and Glycoproteins Research
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- TGF-β signaling in diseases
- Cancer-related Molecular Pathways
- Birth, Development, and Health
- Reproductive tract infections research
- Pesticide Exposure and Toxicity
Shenyang Agricultural University
2017-2024
Harvard University
2023
Guangxi University of Science and Technology
2023
Fudan University Shanghai Cancer Center
2021
Cincinnati Children's Hospital Medical Center
2016
Guangdong Provincial Center for Disease Control and Prevention
2013
Northwest A&F University
2008-2011
Molina Center for Energy and the Environment
2010
Boston University
2008
Using data collected with thermal imaging technology, we found a major reduction in population estimates of colony size the Brazilian free-tailed bat (Tadarida brasiliensis) from 54 million, obtained 1957 without this to 4 million 6 cave colonies southwestern United States. The census was based on human visual observations emergence flights that were subject potentially high errors. recent produced using an accurate, reproducible counting method and complete temporal records emergences....
Contents The objective of this study was to compare the effect two culture media: modified synthetic oviductal fluid (mSOF) and G1.2/G2.2, on developmental competence bovine somatic cell–cloned embryos. Cloned embryos were produced by transferring adult skin fibroblasts into enucleated MII oocytes. After activation, reconstructed randomly allotted either mSOF or G1.2/G2.2 for (the transferred from G1.2 G2.2 days 3 culture). development cloned in these systems compared terms cleavage rate,...
Chilling stress affects plant growth and productivity. However, the multi-underlying mechanisms of chilling tolerance are not well understood. Arabidopsis PCaP2 is involved in regulating dynamic microtubules (MTs) F-actin Ca2+-binding ability. Here, results showed that expression was highly induced roots, cotyledons, true leaves, lateral roots flowers under cold stress. Compared with wild type, PCaP2-overexpressing plants displayed enhanced tolerance, whereas its RNAi mutant were more...
Abstract Myeloid‐derived suppressor cells (MDSCs) are responsible for antitumor immunodeficiency in tumor‐bearing hosts. Primarily, MDSCs classified into 2 groups: monocytic (M)‐MDSCs and polymorphonuclear (PMN)‐MDSCs. In most cancers, PMN‐MDSCs (CD11b + Ly6C low Ly6G cells) represent the abundant MDSC subpopulation. However, functional phenotypic heterogeneities of PMN‐MDSC remain elusive, which delays clinical therapeutic targeting decisions. 4T1 murine tumor model, CD11b were sensitive to...
Triple-negative breast cancer (TNBC) has the characteristics of a complex molecular landscape, aggressive or high proliferation leading to poor prognosis, and behavioral heterogeneity. The purpose present study was determine spatiotemporal expression α-smooth muscle actin (α-SMA)-positive cancer-associated fibroblasts (CAFs) at histological level in 4T1 tumors predict sensitivity 138 drugs patients with TNBC according α-SMA expression. quantitative results fibrosis showed that volume...
Water stress has a major influence on plant growth, development, and productivity. However, the cross-talk networks involved in drought tolerance are not well understood. Arabidopsis PCaP2 is plasma membrane-associated Ca2+-binding protein. In this study, we employ qRT-PCR β-glucuronidase (GUS) histochemical staining to demonstrate that expression was strongly induced roots, cotyledons, true leaves, lateral whole plants under water deficit conditions. Compared with wild type (WT) plants,...
Cytokines are the main regulators of innate and adaptive immunity, mediating communications between cells immune system regulating biological functions, including cell motility, differentiation, growth apoptosis. cytokine receptors have been used in treatment tumors autoimmune diseases, to intervene storms. Indeed, use monoclonal antibodies block cytokine‑receptor interactions, as well antibody‑cytokine fusion proteins has exhibited immense potential for diseases. Compared with these...
Summary There is increasing evidence to show that 2-cell stage mouse blastomeres have differing developmental properties. Additionally, it has been suggested such a difference might be due their distribution of mRNA and/or protein asymmetry. However, date, the exact genes are involved in orientation and order blastomere division not known. In this study, some differentially expressed transcripts were identified. Axin1, cell cycle 25 homolog C (Cdc25c) cyclin-dependent inhibitor 2D (Cdkn2d)...
The effects of specific components in culture medium on embryo physiology have been extensively investigated to optimize vitro systems; however, little attention has paid antibiotics, the reagents used most commonly systems prevent contamination. To investigate potential routine use antibiotics cultured embryos, mouse zygotes were with or without antibiotics. In both groups, developmental rate and cell number blastocysts appear be normal. proportion embryos blastomere fragmentation increased...
During the morula to blastocyst transformation, polarity establishment in outer cells is a prerequisite for trophectoderm lineage specification. This study reveals roles of proteins PATJ and MPDZ fate decision.In mouse preimplantation embryos, cell plays crucial role first its homolog are main members CRB-PALS1-PATJ (CRUMBS-Protein associated with Lin7 1-Pals-associated tight junction protein) apical complex. They act as adaptor connecting CRB-PALS1 proteins, making them essential...
<h3>Background</h3> The continuing spread of drug-resistant gonococci has posed a challenge for successful treatment worldwide. Guangdong Province in South China one the highest resistance rates and large number international migrants. We investigated <i>in vitro</i> antimicrobial susceptibility genotypes <i>N. gonorrhoeae</i> isolated Guangzhou, capital city, 2001–11. <h3>Methods</h3> MICs to penicillin, ceftriaxone, tetracycline, ciprofloxacin, spectinomycin were determined by agar plate...
Abstract Premature depletion of ovarian reserve is a cause female infertility. Plasticizer Bisphenol AF (BPAF) residues have been found in human reproductive-related samples. However, little known about its influence on the reserve. Here, we demonstrate that BPAF exposure causes excessive activation primordial follicles through Hippo signaling young females, resulting rapid exhaustion and, ultimately, premature insufficiency. We oral ingestion disrupts normal estrous cyclicity and induces...
Summary To improve the developmental potential of somatic cell cloned embryos derived from demecolcine (DC) induced-enucleated nuclear transfer (INT), we modified INT procedures by transferring donor nuclei into recipient cytoplasts prior to induced enucleation cytoplasts, and called this technique as reverse-order (RINT). Standard (SNT) were performed controls. The dynamic changes maternal transferred in RINT oocytes monitored evaluate feasibility new (NT) timed immunofluorescence. Timed...
To establish an optimized autologous mitochondria transport technique for oocyte-aging rescue, which minimizes both the patient's pains and damage to oocytes.Experimental laboratory study.Laboratory.Institute of Cancer Research mice.The murine umbilical cord mesenchymal stem cells were isolated from female pup cryopreserved. After aged, its germinal vesicle (GV) oocytes collected treated weaken zona pellucida. Its induced into granulosa (iGCs). The zona-weakened GV aggregated with iGCs...
In vitro production of functional spermatids has special significance in the research spermatogenesis and treatment male infertility. Primordial germ cells (PGCs) are precursors oocyte sperm, which generate totipotent cells. Studies have shown that PGCs potential ability to develop meiotic vitro. Here we retinoic acid (RA) leads PGC differentiation, SCF can improve efficiency induction. We indicate an efficient approach produce haploid from chicken presence RA stem cell factor (SCF)....