A5055994083- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- COVID-19 diagnosis using AI
- HIV Research and Treatment
- Viral Infections and Outbreaks Research
- Adolescent Sexual and Reproductive Health
- HIV-related health complications and treatments
- Pharmaceutical Practices and Patient Outcomes
- SARS-CoV-2 and COVID-19 Research
- Health Systems, Economic Evaluations, Quality of Life
- Ethics in Clinical Research
- Medication Adherence and Compliance
- Maternal Mental Health During Pregnancy and Postpartum
- COVID-19 Clinical Research Studies
- Global Maternal and Child Health
- HIV, Drug Use, Sexual Risk
- Vaccine Coverage and Hesitancy
- Global Health and Surgery
- Social Media in Health Education
- Diverse Scientific Research Studies
- scientometrics and bibliometrics research
- Analytical Chemistry and Chromatography
- Pregnancy and Medication Impact
- Data-Driven Disease Surveillance
- Family Caregiving in Mental Illness
University of Bern
2015-2024
Institute of Social and Preventive Medicine
2019-2024
rVSV-ZEBOV is a recombinant, replication competent vesicular stomatitis virus-based candidate vaccine expressing surface glycoprotein of Zaire Ebolavirus. We tested the effect in preventing Ebola virus disease contacts and recently confirmed cases Guinea, west Africa.
ABSTRACT BACKGROUND There is disagreement about the level of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We conducted a living systematic review and meta-analysis to address three questions: 1. amongst people who become infected with SARS-CoV-2, what proportion does not experience symptoms at all during their infection? 2. Amongst SARS-CoV-2 infection are when diagnosed, will develop later? 3. What transmission accounted for by either throughout...
Introduction Multimorbidity and polypharmacy are important risk factors for drug-related hospital admissions (DRAs). DRAs often linked to prescribing problems (overprescribing underprescribing), as well non-adherence with drug regimens different reasons. In this trial, we aim assess whether a structured medication review compared standard care can reduce in multimorbid older patients polypharmacy. Methods analysis OPtimising thERapy prevent Avoidable Multimorbid people is European...
Abstract Background The EQ-5D-3L and EQ-5D-5L are two generic health-related quality of life measures, which may be used in clinical health economic research. They measure impairment 5 aspects health: mobility, self-care, usual activities, pain/discomfort anxiety/depression. aim this study was to assess the performance measuring self-reported status older patients with substantial multimorbidity associated polypharmacy. Methods Between 2017 2019, we administered a subset participating OPERAM...
People with human immunodeficiency virus (PWH) on first-line, nonnucleoside reverse-transcriptase inhibitor-based antiretroviral therapy (ART) were routinely switched to tenofovir-lamivudine-dolutegravir. We examined virologic outcomes and drug resistance in ART programs Malawi, where switching was irrespective of viral load, Zambia, depended a load <1000 copies/mL the past year. compared risk viremia (≥400 copies/mL) at 1 2 years by switch between countries using exact methods logistic...
Introduction Timely descriptions of HIV service characteristics and their evolution over time across diverse settings are important for monitoring the scale-up evidence-based program strategies, understanding implementation landscape, examining delivery factors that influence care outcomes. Methods The International epidemiology Databases to Evaluate AIDS (IeDEA) consortium undertakes periodic cross-sectional surveys on availability at participating treatment sites characterize trends inform...
Abstract Aim To evaluate the relationship between breath volatile organic compounds (VOCs) and glycaemic states in individuals with type 1 diabetes (T1D), focusing on identifying specific VOCs as biomarkers for hypoglycaemia to offer a non‐invasive diabetes‐monitoring method. Materials Methods Ten T1D underwent induced clinical setting. Breath samples, collected every 10‐15 minutes, were analysed using gas chromatography–ion mobility spectrometry (GC‐IMS). Correlation analysis machine...
Inappropriate polypharmacy has been linked with adverse outcomes in older, multimorbid adults. OPERAM is a European cluster-randomized trial aimed at testing the effect of structured pharmacotherapy optimization intervention on preventable drug-related hospital admissions adults aged 70 years or older. Clinical results showed pattern reduced admissions, but without statistical significance. In this study we assessed cost-effectiveness optimisation intervention.We performed pre-planned...
Objectives To examine the proportion of people living with HIV who screen positive for common mental disorders (CMD) and associations between CMD self-reported adherence to antiretroviral therapy (ART). Setting Sixteen government-funded health facilities in rural Bikita district Zimbabwe. Design Cross-sectional study. Participants HIV-positive non-pregnant adults, aged 18 years or older, lived had received ART at least 6 months. Outcome measures The primary outcome was participants screening...
The widespread use of the integrase strand transfer inhibitor (INSTI) dolutegravir (DTG) in first- and second-line antiretroviral therapy (ART) may facilitate emerging resistance. We combined data from HIV cohorts to examine patterns drug resistance mutations (DRMs) identify risk factors for DTG
Importance Common mental disorders (CMD), which include depression and anxiety, are prevalent among people living with HIV associated suboptimal antiretroviral therapy (ART) adherence. Objective To assess the effect of a lay health worker–led psychological intervention on ART adherence, virologic suppression, symptoms. Design, Setting, Participants Open-label pragmatic cluster trial 1:1 block randomization 16 facilities in rural Bikita, Zimbabwe. Recruitment occurred from October 2018 to...
HIV drug resistance poses a challenge to the United Nation's goal of ending HIV/AIDS epidemic. The integrase strand transfer inhibitor (InSTI) dolutegravir, which has higher barrier, was endorsed by World Health Organization in 2019 for first-, second-, and third-line antiretroviral therapy (ART). This multiplicity roles dolutegravir ART may facilitate emergence resistance.
Introduction HIV drug resistance poses a challenge to the United Nation’s goal of ending HIV/AIDS epidemic. The integrase strand transfer inhibitor (InSTI) dolutegravir, which has higher barrier, was endorsed by WHO in 2019 for first-line, second-line and third-line antiretroviral therapy (ART). This multiplicity roles dolutegravir ART may facilitate emergence resistance. Methods analysis Nested within International epidemiology Databases Evaluate AIDS (IeDEA), DTG RESIST is multicentre...
The International epidemiology Databases to Evaluate AIDS conducts research in several regions, including Southern Africa. We assessed authorship inequalities for the African region, which is led by South and Swiss investigators.
Common mental disorders (CMD) are prevalent in people living with HIV and associated suboptimal antiretroviral therapy (ART) adherence.
Background: The International epidemiology Databases to Evaluate AIDS (IeDEA) conducts research in seven regions, including four regions sub-Saharan Africa. We assessed authorship inequalities for the Southern African region, which is led by South and Swiss investigators.Methods: analysed author characteristics authorships of publications from 2007-2020 gender, country income group, time citation impact. used 2020 World Bank categories define groups relative ratio (RCR) assess Authorship...