A5013791675- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Hemodynamic Monitoring and Therapy
- Renal function and acid-base balance
- Electrolyte and hormonal disorders
- Aerodynamics and Fluid Dynamics Research
- Phonocardiography and Auscultation Techniques
- Immune Response and Inflammation
- Pancreatitis Pathology and Treatment
- Muscle and Compartmental Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Ultrasound in Clinical Applications
- Hydraulic and Pneumatic Systems
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- Cardiac Arrest and Resuscitation
Emma Kinderziekenhuis
2016-2022
University of Amsterdam
2018-2022
Amsterdam University Medical Centers
2018-2020
Amsterdam UMC Location University of Amsterdam
2016-2019
Radboud University Nijmegen
2019
Radboud University Medical Center
2019
University Medical Center
2019
Intensive Care Society
2019
Results from preclinical studies suggest that age-dependent differences in host defense and the pulmonary renin–angiotensin system (RAS) are responsible for observed epidemiology of acute respiratory distress syndrome (ARDS) between children adults. The present study compares biomarkers RAS bronchoalveolar lavage (BAL) fluid neonates, children, adults, older adults with ARDS. In this prospective observational study, we enrolled mechanical ventilated ARDS patients categorized into four age...
Neutrophils are the predominant inflammatory cells recruited to respiratory tract as part of innate immune response viral infections. Recent reports indicate existence distinct functional neutrophil subsets in circulatory compartment adults, following severe conditions. Here, we evaluated occurrence blood and broncho-alveolar lavage fluid during infection infants based on CD16/CD62L expression. We show that course may develop four heterogeneous (mature, immature, progenitor, suppressive...
Viral-lower respiratory tract disease is common in young children worldwide and associated with high morbidity. Acute failure due to viral-lower necessitates PICU admission for mechanical ventilation. In critically ill patients settings, early fluid overload adverse outcomes such as prolonged ventilation increased mortality. It unclear, however, if this also applies induced acute failure. study, we aimed investigate the relation of mechanically ventilated a retrospective...
Appropriate fluid management in mechanically ventilated critically ill children remains an important challenge and topic of active discussion pediatric intensive care medicine. An increasing number studies show association between a positive balance or overload adverse outcomes. However, to date, no international consensus regarding removal strategies exists. The aim this study was obtain more insight into the current clinical practice therapy children. On behalf section cardiovascular...
Background: Fluid overload is common in critically ill children and associated with adverse outcome. Therefore, restricting fluid intake may be beneficial. This study aims to the feasibility of a randomized controlled trial (RCT) comparing conservative standard, more liberal, strategy management mechanically ventilated pediatric patients acute respiratory tract infection (ARTI). Methods: single, tertiary referral pediatic intensive care unit (PICU). Twenty-three receiving mechanical...
Experimental acute lung injury models are often used to increase our knowledge on the respiratory distress syndrome (ARDS), however, existing animal do not take into account impact of specific fluid strategies development injury. In contrast, current literature strongly suggests that management have a significant clinical outcome patients with ARDS. Thus, it is important characterize role in experimental this study we investigated effect two different commonly variables short-term model...
Lung ultrasound (LUS) is an emerging tool that may be used in the diagnosis and follow-up of children with viral bronchiolitis. In this study, we describe LUS abnormalities receiving invasive mechanical ventilation (IMV) for severe bronchiolitis pediatric intensive care unit (PICU). Our aim was to semiquantify loss aeration examine association between serial scores oxygenation anomaly, as a marker disease severity.Prospective, observational study single-center PICU.LUS performed by multiple...
Abstract Background Alkaline phosphatase (AP), a dephosphorylating enzyme, is involved in various physiological processes and has been shown to have anti-inflammatory effects. Aim To determine the correlation between pulmonary AP activity markers of inflammation invasively ventilated critically ill patients with or without acute respiratory distress syndrome (ARDS), investigate effect administration recombinant on well-established lung injury model rats Methods was determined compared levels...
In acute respiratory distress syndrome (ARDS), uncontrolled production of activators coagulation and proinflammatory mediators results in a shift from an adequate local innate immune response to hypercoagulability inflammation. This study aimed investigate whether the protease inhibitors antithrombin (AT) alpha-1 inhibitor (A1PI) may attenuate exaggerated pulmonary response.Lung injury was induced either by single intranasal administration lipopolysaccharide (LPS) (5 mg/kg) BALB/c mice or...
Intravenous fluids are widely used to treat circulatory deterioration in pediatric acute respiratory distress syndrome (PARDS). However, the accumulation of first days PARDS is associated with adverse outcome. As such, early fluid restriction may prove beneficial, yet effects such a strategy on cardiopulmonary physiology unclear. In this study, we compared effect restrictive liberal hemodynamic response and formation pulmonary edema an animal model PARDS. Sixteen mechanically ventilated...
Abstract Background: Fluid overload is common in critically ill children and associated with adverse outcome. Therefore, restricting fluid intake may be beneficial. This study aims to pilot the feasibility of a RCT comparing conservative standard, more liberal, strategy management mechanically ventilated (MV) pediatric patients acute respiratory tract infection (ARTI). Methods: single, tertiary referral pediatic intensive care unit. Twenty-three receiving MV for ARTI, without ongoing...
Abstract Background: Fluid overload is common in critically ill children and associated with adverse outcome. Therefore, restricting fluid intake may be beneficial. This study aims to the feasibility of a randomized controlled trial (RCT) comparing conservative standard, more liberal, strategy management mechanically ventilated pediatric patients acute respiratory tract infection (ARTI). Methods: single, tertiary referral pediatic intensive care unit (PICU). Twenty-three receiving mechanical...