A5018278996- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical studies and practices
- Anesthesia and Sedative Agents
- Biosimilars and Bioanalytical Methods
- Mechanical Circulatory Support Devices
- Pneumonia and Respiratory Infections
- Heart Failure Treatment and Management
- Electrolyte and hormonal disorders
- Central Venous Catheters and Hemodialysis
- Renal function and acid-base balance
- Neonatal Health and Biochemistry
- Influenza Virus Research Studies
- Intensive Care Unit Cognitive Disorders
- Epilepsy research and treatment
- Effects and risks of endocrine disrupting chemicals
- Pharmacological Effects and Toxicity Studies
- Anesthesia and Pain Management
- Veterinary Pharmacology and Anesthesia
- Antimicrobial Resistance in Staphylococcus
- Fuel Cells and Related Materials
- Acute Kidney Injury Research
- Pharmacological Effects and Assays
- Neonatal Respiratory Health Research
- Pharmacogenetics and Drug Metabolism
- Cardiac Arrest and Resuscitation
King Abdullah International Medical Research Center
2025
King Saud bin Abdulaziz University for Health Sciences
2025
National Guard Health Affairs
2025
University Hospitals of Leicester NHS Trust
2012-2024
Glenfield Hospital
2007-2024
University of Leicester
2008-2024
Loughborough University
2021
American Pharmacists Association
2013
Cluster in Biomedicine
2012
Boston Children's Hospital
2008
Antibiotic dosing in neonates varies between countries and centres, suggesting suboptimal exposures for some neonates. We aimed to describe variations factors influencing the variability of frequently used antibiotics European NICUs help define strategies improvement. A sub-analysis Study Neonatal Exposure Excipients point prevalence study was undertaken. Demographic data receiving any antibiotic on day within one three two-week periods from January June 2012, dose, interval route...
Aims Extracorporeal membrane oxygenation (ECMO) is a life support system used during severe respiratory or cardiorespiratory failure. The objective of this study was to characterize the population pharmacokinetics vancomycin ECMO. Methods A model developed using WinNonMix (Version 2.0.1) from total 366 plasma observations in 45 patients, including term neonates, older children and adults. utilized both rich prospective sparse retrospective data. Prospective samples were drawn at baseline...
<h3>Background:</h3> Little is known about exposure of preterm infants to excipients during routine clinical care. <h3>Objective:</h3> To document excipient in vulnerable babies a single centre, taking into account chronic lung disease (CLD) as marker illness severity. <h3>Design:</h3> Excipient after treatment with eight oral liquid medications was determined by retrospectively analysing the drug charts admitted neonatal unit. <h3>Setting:</h3> The Leicester Neonatal Service....
Sedative agents are routinely administered to critically ill patients, both on and off extracorporeal membrane oxygenation (ECMO), enable patients be comfortable facilitate patient management. It has been observed empirically in our paediatric intensive care unit that doses of sedative drugs required achieve desired levels sedation ECMO far greater than those used non-ECMO patients. These differences could not simply accounted for by types, clinical status or levels. We therefore undertook...
The objective of this study was to characterize cefazolin serum pharmacokinetics in children before, during and after cardiopulmonary bypass (CPB), order derive an evidence-based dosing regimen.This included who received before surgical incision, cessation CPB surgery. Blood samples total unbound concentrations were collected CPB. concentration-time profiles analysed using population pharmacokinetic modelling predictors for interindividual variability parameters investigated. Subsequently,...
The Duffy (FY) is considered one of the clinically significant blood group systems. Anti-Fya and anti-Fyb can cause hemolytic transfusion reactions disease fetus newborn. This study investigated prevalence FY antigens phenotypes in Saudi Arabian non-Saudi donors. A total 25611 donors were enrolled this from January 2020 to May 2024, at bank center King Abdulaziz Medical City-Western Region (KAMC-WR), Jeddah, Arabia. Serotyping was conducted identify Fya Fyb as well four using a solid phase...
Although the pharmacokinetics of midazolam in critically ill children has been described, there are no such reports extracorporeal membrane oxygenation.The and 1-hydroxy after continuous infusion (50-250 microg. kg(-1). h(-1)) were determined 20 neonates undergoing oxygenation. Patients randomized into two groups: group 1 (n = 10) received extracorporeally (into circuit), 2 drug via central or peripheral access. Blood samples for determination plasma concentrations taken at baseline, 2, 4,...
Aims Dried blood spots ( DBS ) alongside micro‐analytical techniques are a potential solution to the challenges of performing pharmacokinetic PK studies in children. However, methods have received little formal evaluation clinical settings relevant The aim present study was determine model for caffeine using ‘ /microvolume platform’ preterm infants. Methods samples were collected prospectively from premature babies receiving treatment apnoea prematurity. A non‐linear mixed effects approach...
Abstract Aims Whether and when glomerular filtration rate (GFR) in preterms catches up with term peers is unknown. This study aims to develop a GFR maturation model for (pre)term-born individuals from birth 18 years of age. Secondarily, the function applied data different renally excreted drugs. Methods We combined published inulin clearance values serum creatinine (Scr) concentrations (pre)term born throughout childhood. Inulin was assumed be equal GFR, Scr reflect synthesis rate/GFR....
Objectives: Once-daily gentamicin therapy is becoming increasingly common in pediatric practice; however, little known about pharmacokinetics critical illness. Gentamicin exhibits concentration dependant killing; thus, peak serum concentrations at least eight times higher than minimum inhibition of the target organism have been recommended. We wanted to derive pharmacokinetic parameters for illness and evaluate whether a dose 8 mg/kg provides an adequate (>16 mg/L). Patients Interventions:...
Extracorporeal membrane oxygenation (ECMO) is known to affect pharmacokinetics and hence optimum dosing. The aim of this open label, prospective study was investigate the oseltamivir (prodrug) carboxylate (active metabolite) during ECMO. Fourteen adult patients with suspected or confirmed H1N1 influenza were enrolled in study. Oseltamivir 75 mg enterally administered twice daily blood samples for pharmacokinetic assessment taken on day 1 5. A multi-compartmental model describe developed...
It is often stated that venovenous extracorporeal membrane oxygenation (VV ECMO) should not be used in inotrope dependent patients. our practice to use VV ECMO most patients with respiratory failure even though many of these are receiving significant doses inotropes. Our objective was review the mode relation precannulation inotropes administered neonates treated for failure. Forty-three consecutive case notes were reviewed. Data collected basic demographic and parameters. Inotropic...
The 2019 update to the US consensus guideline for vancomycin therapeutic monitoring advocates using Bayesian-guided personalised dosing maximise efficacy and minimise toxicity of vancomycin. We conducted an observational cohort study implementation bed-side in vascular surgery patients.Over a 9-month prospective period, patients were dosed decision tool (DoseMeRx) compared retrospectively with control group admitted same ward 14 months prior standard algorithmic approach. Primary endpoints...
Drug disposition is affected during extracorporeal membrane oxygenation (ECMO). This study investigates the dose-concentration relationship of midazolam in neonates requiring ECMO continuous infusion into circuit (extracorporeally; n = 10) and intravenously (n 10). Data on hourly doses sedation scores were collected for 120 hours. Plasma concentrations analyzed at times 0, 2, 4, 6, 12, 18, 24, every 12 hours thereafter. Both groups clinically similar. Mean (standard deviation) dose all...