A5029518117- Pharmaceutical studies and practices
- Pediatric Pain Management Techniques
- Antibiotics Pharmacokinetics and Efficacy
- Child and Adolescent Health
- Health Systems, Economic Evaluations, Quality of Life
- Patient Safety and Medication Errors
- Neonatal Respiratory Health Research
- Pharmaceutical Economics and Policy
- Pharmacogenetics and Drug Metabolism
- Anesthesia and Neurotoxicity Research
- Attention Deficit Hyperactivity Disorder
- Electronic Health Records Systems
- Cardiac pacing and defibrillation studies
- Childhood Cancer Survivors' Quality of Life
- Clinical practice guidelines implementation
- Healthcare Technology and Patient Monitoring
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
Erasmus MC - Sophia Children’s Hospital
2016-2023
Radboud University Nijmegen
2020-2023
Radboud University Medical Center
2020-2023
University Medical Center
2022-2023
Sophia Revalidatie
2021
Erasmus MC
2021
Radboud Institute for Molecular Life Sciences
2020
A drug is granted a license for use after thorough assessment of risks and benefits based on high-quality scientific proof its efficacy safety. Many drugs that are relevant to children not licensed in this population implying the pediatric has been made at all, negative risk-benefit balance children, or insufficient information establish balance. Use without positive exposes potential lack efficacy, unknown toxicity, harm. To aid guideline committees individual prescribers, we here present...
As chloroquine (CHQ) is part of the Dutch Centre for Infectious Disease Control coronavirus disease 2019 (COVID‐19) experimental treatment guideline, pediatric dosing guidelines are needed. Recent data suggest that existing World Health Organization (WHO) children with malaria suboptimal. The aim our study was to establish best‐evidence inform CHQ doses infected COVID‐19. A previously developed physiologically‐based pharmacokinetic (PBPK) model used simulate exposure in adults and verified...
Dexmedetomidine is currently off-label for use in pediatric clinical care worldwide. Nevertheless, it frequently prescribed to patients as premedication prior induction of anesthesia or procedural sedation. There ample literature on the pharmacokinetics, efficacy and safety dexmedetomidine this vulnerable patient population, but there a general lack consensus dosing. In project, we aimed standardized workflow Dutch Pediatric Formulary establish best evidence-based dosing guidelines The...
Neonatal drug information (DI) is essential for safe and effective pharmacotherapy in (pre)term neonates. Such usually absent from labels, making formularies a crucial part of the neonatal clinician's toolbox. Several exist worldwide, but they have never been fully mapped or compared content, structure workflow. The objective this review was to identify formularies, explore (dis)similarities, raise awareness their existence. were identified through self-acquaintance, experts structured...
Abstract: Many drugs are used off-label in neonates which leads to large variation prescribed and dosages neonatal intensive care units (NICUs). The NeoDose project aimed develop best evidence dosing recommendations (DRs) for term preterm using a three-step approach: 1) drug selection, 2) establishing consensus-based DRs, 3) DRs. Methods: selection of was based on frequency prescribing, availability DR the Dutch Pediatric Formulary, labeling status. Clinical need, pharmacological diversity,...
Introduction Off‐label drug use in the paediatric population is common, and lack of high‐quality efficacy studies poses patients at risk for failing pharmacotherapy. Next to studies, pharmacokinetic (PK) are increasingly used inform dose selection. As resources trials limited, we aimed summarize existing PK identify knowledge gaps available evidence supporting dosing recommendations, thereby taking cardiovascular drugs as proof concept. Methods For each drug, indication prespecified age...
Background : Modeling and simulation is increasingly used to study pediatric pharmacokinetics, but clinical implementation of age-appropriate doses lags behind. Therefore, we aimed develop model-informed using published pharmacokinetic data a decision framework adjust dosing guidelines based on these doses, piperacillin amikacin in critically ill children as proof concept. Methods Piperacillin models were extracted from literature. Concentration-time profiles simulated for various regimens...
Zusammenfassung Trotz verbesserter gesetzlicher Rahmenbedingungen bei der Entwicklung von Arzneimitteln (AM) für Kinder bestehen viele pädiatrische Therapiebereiche und v. a. die jüngsten Altersgruppen immer noch große Defizite in AM-Versorgung. Daher müssen AM außerhalb Zulassung (off-label) somit ohne Fachinformationen angewendet werden. Dadurch besteht ein erhöhtes Risiko inadäquate Dosierungen sowie fehlende oder unerwünschte Wirkungen. In Off-label-Anwendung haben Verschreibende eine...
Calculation errors are the most common dosing in paediatrics. While health information technology has been advocated to improve patient safety, broad implementation of computer-calculated paediatric setting is delayed for lack computable, explicit and unambiguous guidelines. The structured digital guidelines Dutch Paediatric Formulary permitted development a calculator that combines drug recommendations formulary with variables. We took into account European Union Medical Devices Directive...
The structured digital dosing guidelines of the web-based Dutch Paediatric Formulary provided opportunity to develop an integrated paediatric dose calculator. In a simulated setting, we tested ability this calculator reduce calculation errors.Volunteer healthcare professionals were allocated one two groups, manual versus use Professionals in both groups given access questionnaire with 14 patient cases for which doses had be calculated. effect group allocation on probability making error was...